Catalog No.
RVV16803
Species reactivity
AAV2, AAV2 7m8, AAV3, Anc80. Do not react with AAV1, AAV4, AAV5, AAV6, AAV7, AAV8, AAV9, AAV11, AAV12, AAVDJ, AAVrh10, AAVrh74
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Target
AAV2 capsids, Capsids (intact particle), Capsid protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P03135
Applications
Dot blot, ELISA, ICC/IF, IP, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
A20R
CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production., PMID:39980803
Engineering sialylated N-glycans on adeno-associated virus capsids for targeted gene delivery and therapeutic applications., PMID:39938722
The Structural, Biophysical, and Antigenic Characterization of the Goose Parvovirus Capsid., PMID:39858848
Heparan sulfate proteoglycan affinity of adeno-associated virus vectors: Implications for retinal gene delivery., PMID:39805508
Validation of an ELISA method for determination of physical particle titre of AAV2-based vector preparations., PMID:39601639
Characterization of anti-AAV2 neutralizing antibody levels in sheep prior to and following intravitreal AAV2.7m8 injection., PMID:39472677
Seroprevalence of binding and neutralizing antibodies against 18 adeno-associated virus types in patients with neuromuscular disorders., PMID:39399494
CRISPR screen for rAAV production implicates genes associated with infection., PMID:39345423
Inhalation of SP-101 Followed by Inhaled Doxorubicin Results in Robust and Durable hCFTRΔR Transgene Expression in the Airways of Wild-Type and Cystic Fibrosis Ferrets., PMID:39155828
Gene Therapy for Non-Hereditary Retinal Disease: Age-Related Macular Degeneration, Diabetic Retinopathy, and Beyond., PMID:38927656
Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages., PMID:38885242
An investigation of the immune epitopes of adeno-associated virus capsid-derived peptides among hemophilia patients., PMID:38660620
Novel assay format for total anti-adeno-associated virus antibody detection with low capsid consumption and built-in specificity control., PMID:38497775
Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation., PMID:38485924
Rationally engineered novel AAV capsids for intra-articular gene delivery., PMID:38435130
Multicenter assessment and longitudinal study of the prevalence of antibodies and related adaptive immune responses to AAV in adult males with hemophilia., PMID:38355967
Human Bocavirus 1 NP1 acts as an ssDNA-binding protein to help AAV2 DNA replication and cooperates with RPA to regulate AAV2 capsid expression., PMID:38323812
A novel capsid-XL32-derived adeno-associated virus serotype prompts retinal tropism and ameliorates choroidal neovascularization., PMID:38016335
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion., PMID:37814449
Rational design and experimental evaluation of peptide ligands for the purification of adeno-associated viruses via affinity chromatography., PMID:37728197
Modifying immune responses to adeno-associated virus vectors by capsid engineering., PMID:37693943
Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice., PMID:37386155
Prevalence of Neutralizing Antibodies against Adeno-Associated Virus Serotypes 1, 2, and 9 in Non-Injected Latin American Patients with Heart Failure-ANVIAS Study., PMID:36982654
A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant., PMID:36970652
rAAV immunogenicity, toxicity, and durability in 255 clinical trials: A meta-analysis., PMID:36389770
Seroprevalence of Adeno-Associated Virus Neutralizing Antibodies in Males with Duchenne Muscular Dystrophy., PMID:36324212
Identification of Novel Retinal Pericyte-Targeting rAAV Vectors Through Directed Evolution., PMID:36018583
Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy., PMID:35976053
Enhanced Transduction of P2X7-Expressing Cells with Recombinant rAAV Vectors., PMID:35776323
Immunogenicity of Novel AAV Capsids for Retinal Gene Therapy., PMID:35741009
MSD-based assays facilitate a rapid and quantitative serostatus profiling for the presence of anti-AAV antibodies., PMID:35573045
Long-term follow-up of liver-directed, adeno-associated vector-mediated gene therapy in the canine model of hemophilia A., PMID:35405003
Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors., PMID:34928979
Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants., PMID:34757842
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches., PMID:34685692
Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2., PMID:34509611
Engineered adeno-associated virus 3 vector with reduced reactivity to serum antibodies., PMID:33927271
Repeat Dosing of AAV2.5T to Ferret Lungs Elicits an Antibody Response That Diminishes Transduction in an Age-Dependent Manner., PMID:33209961
Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies., PMID:33145372
Long-Term Follow-Up of the First in Human Intravascular Delivery of AAV for Gene Transfer: AAV2-hFIX16 for Severe Hemophilia B., PMID:32559433
Structural characterization of a bat Adeno-associated virus capsid., PMID:32522552
Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-Linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy., PMID:32414297
Intra-striatal AAV2.retro administration leads to extensive retrograde transport in the rhesus macaque brain: implications for disease modeling and therapeutic development., PMID:32332773
Immune Response Mechanisms against AAV Vectors in Animal Models., PMID:31970198
Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2., PMID:31859208
Chimeric Capsid Proteins Impact Transduction Efficiency of Haploid Adeno-Associated Virus Vectors., PMID:31835440
Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors., PMID:31687421
Prevalence and Relevance of Pre-Existing Anti-Adeno-Associated Virus Immunity in the Context of Gene Therapy for Crigler-Najjar Syndrome., PMID:31502485
Next-generation AAV vectors-do not judge a virus (only) by its cover., PMID:31261383
Reducing off target viral delivery in ovarian cancer gene therapy using a protease-activated AAV2 vector platform., PMID:31252037
For research use only. Not for human or drug use.
