Catalog No.
YHC12101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr347-Asp680
Predicted molecular weight
38.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P05023
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha-1, ATP1A1
Glutamate Supplementation Regulates Nitrogen Metabolism in the Colon and Liver of Weaned Rats Fed a Low-Protein Diet., PMID:40362775
The cardiac glycoside periplocymarin sensitizes gastric cancer to ferroptosis via the ATP1A1-Src-YAP/TAZ-TFRC axis., PMID:40311597
Prevalence of KCNJ5 mutations in aldosterone-producing adenomas among Malaysian primary aldosteronism patients: Genotype-phenotype correlation., PMID:40302475
An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans., PMID:40169113
Components in Prunus mume and their targets in the alleviation of severe depression identified using network pharmacology analysis., PMID:40116198
Multi-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example., PMID:40057776
Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4., PMID:39902679
Target Identification of Marine Natural Product Odoamide:Odoamide Induces Apoptotic Cell Death by Targeting ATPase Na+/K+ Transporting Subunit Alpha 1 (ATP1A1)., PMID:39754293
Whole genome sequencing reveals candidate causal genetic variants for spastic syndrome in Holstein cattle., PMID:39732776
GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma., PMID:39730361
Exploring variances in meat quality between Qingyuan partridge chicken and Cobb broiler: Insights from combined multi-omics analysis., PMID:39721276
High-level L-Gln compromises intestinal amino acid utilization efficiency and inhibits protein synthesis by GCN2/eIF2α/ATF4 signaling pathway in piglets fed low-crude protein diets., PMID:39659992
Verteporfin combined with ROCK inhibitor promotes the restoration of corneal endothelial cell dysfunction in rats., PMID:39571917
SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front., PMID:39448803
[Study on the antihypertensive mechanism of acupuncture at "Renying" (ST9) and "Zusanli" (ST36) via gastrin/cholecystokinin B receptors]., PMID:39433364
Somatic GNAQ, CTNNB1, and CACNA1C Mutations in Cat Aldosterone-Secreting Tumors., PMID:39429164
Influence of Intraocular Pressure on the Expression and Activity of Sodium-Potassium Pumps in the Corneal Endothelium., PMID:39337712
The natural compound periplogenin suppresses the growth of prostate carcinoma cells by directly targeting ATP1A1., PMID:39227746
Dihydroartemisinin inhibits ATP6 activity, reduces energy metabolism of hepatocellular carcinoma cells, promotes apoptosis and inhibits metastasis via CANX., PMID:39161338
Uncovering key steps in FGF12 cellular release reveals a common mechanism for unconventional FGF protein secretion., PMID:39158730
Effects of long-term dehydration and quick rehydration on the camel kidney: pathological changes and modulation of the expression of solute carrier proteins and aquaporins., PMID:39148099
Targeting the Sodium-Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia., PMID:39024560
Na,K-ATPase Expression Can Be Limited Post-Transcriptionally: A Test of the Role of the Beta Subunit, and a Review of Evidence., PMID:39000521
Sleep deprivation induces corneal endothelial dysfunction by downregulating Bmal1., PMID:38907352
NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis., PMID:38852542
Hypoxia related genes modulate in similar fashion in skin fibroblast cells of yak (Bos grunniens) adapted to high altitude and native cows (Bos indicus) adapted to tropical climate during hypoxia stress., PMID:38814473
Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death., PMID:38796484
Hypomethylation of ATP1A1 Is Associated with Poor Prognosis and Cancer Progression in Triple-Negative Breast Cancer., PMID:38730618
Intracranial aneurysm circulating exosome-derived LncRNA ATP1A1-AS1 promotes smooth muscle cells phenotype switching and apoptosis., PMID:38728254
Role of Na/K-ATPase α1 caveolin-binding motif in adipogenesis., PMID:38708522
Occupational second-hand smoke exposure: A comparative shotgun proteomics study on nasal epithelia from healthy restaurant workers., PMID:38685369
Recurrent ATP1A1 variant Gly903Arg causes developmental delay, intellectual disability, and autism., PMID:38504481
A study on the subchronic toxicity of triclocarban to the early-life development of oryzias melastigma and focused on the analysis of osmoregulatory regulation mechanisms., PMID:38437996
Involvement of the Na+, K+-ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors., PMID:38338921
Impact of culture media on primary human corneal endothelial cells derived from old donors., PMID:38316204
Shared Proteins and Pathways of Cardiovascular and Cognitive Diseases: Relation to Vascular Cognitive Impairment., PMID:38252700
Associations between genetically predicted plasma protein levels and Alzheimer's disease risk: a study using genetic prediction models., PMID:38212844
The Na/K-ATPase α1/Src Signaling Axis Regulates Mitochondrial Metabolic Function and Redox Signaling in Human iPSC-Derived Cardiomyocytes., PMID:38137428
Intracellular K+ Limits T-cell Exhaustion and Preserves Antitumor Function., PMID:38063845
Dihydroartemisinin inhibits liver cancer cell migration and invasion by reducing ATP synthase production through CaMKK2/NCLX., PMID:38020296
Cycle-dependent sex differences in expression of membrane proteins involved in cerebrospinal fluid secretion at rat choroid plexus., PMID:37946101
ATP1A1/BCL2L1 predicts the response of myelomonocytic and monocytic acute myeloid leukemia to cardiac glycosides., PMID:37904054
Exploring the anti-glioma mechanism of the active components of Cortex Periplocae based on network pharmacology and iTRAQ proteomics in vitro., PMID:37901992
Normalization of the ATP1A1 Signalosome Rescinds Epigenetic Modifications and Induces Cell Autophagy in Hepatocellular Carcinoma., PMID:37830582
ATP1A1-linked diseases require a malfunctioning protein product from one allele., PMID:37659504
Silencing of ATP1A1 attenuates cell membrane disruption by nanosecond electric pulses., PMID:37566922
Auditory Neuropathy Spectrum Disorder Progressing with Motor and Sensory Neuropathy Caused by an ATP1A1 Variant., PMID:37558483
Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer., PMID:37407874
ASO Author Reflections: Expression and Role of ATP1A1 in Colon Cancer., PMID:37341911
Transcriptomics reveals key regulatory pathways and genes associated with skin diseases induced by face paint usage., PMID:37236445
For research use only. Not for human or drug use.
