Catalog No.
YHC10501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys205
Predicted molecular weight
25.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04792
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Estrogen-regulated 24 kDa protein, Heat shock 27 kDa protein, SRP27, Heat shock protein beta-1, Stress-responsive protein 27, HspB1, 28 kDa heat shock protein, HSPB1, HSP27, HSP28, HSP 27
HSP Inhibitor Sensitize Resistant MCF-7 Cells to Doxorubicin through Suppressing HSP90AB4P Pseudogene and HSPB1 Expression., PMID:40511810
The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis., PMID:40504332
Key Ferroptosis Genes and their Predictive and Diagnostic Value in Fanconi Anemia., PMID:40432442
Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets., PMID:40369521
HSPB1/KDM1 A facilitates ANXA2 expression via hypomethylated DNA promoter to inhibit ferroptosis and enhance gemcitabine resistance in pancreatic cancer., PMID:40366396
Single-cell proteomics analysis of human oocytes during GV-to-MI transition., PMID:40359387
DA.Vra1-congenic rats display increased gene expression and Schwann cell apoptosis but unaffected nerve regeneration compared to parental DA rats after sciatic nerve injury and repair., PMID:40356597
Heat shock protein B1-mediated ferroptosis regulates mitochondrial dysfunction in adipose tissue of ketotic dairy cows., PMID:40348370
SLC7A11-HSPB1 Axis: A Novel Mechanism for Hepatocellular Carcinoma Progression and Ferroptosis Regulation., PMID:40339903
Coevolution in human small Heat Shock Protein 1 is promoted by interactions between the Alpha-Crystallin domain and the disordered regions., PMID:40323908
The Impact of Recreational Diving to a Depth of 40 m on Selected Intracellular DAMPs., PMID:40243713
Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins., PMID:40241479
COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma., PMID:40198582
Investigation of new autoantibodies in urothelial bladder cancer for biomarker discovery using immunoproteomics., PMID:40163213
Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution., PMID:40146081
Multiomic traits reveal that critical irinotecan-related core regulator FSTL3 promotes CRC progression and affects ferroptosis., PMID:40140870
Targeting Cancer With Bifunctional Peptides: Mechanism of Cell Entry and Inciting Cell Death., PMID:40138733
HSPB1 suppresses oxLDL-induced vascular smooth muscle cell ferroptosis by inhibiting DPP4., PMID:40132776
Temperature effects on development and lifelong behavior in zebrafish., PMID:40112540
Development and validation of a prognosis prediction model for overall survival in correlation between butyrate metabolism and gastric cancer prognosis: Mendelian randomization and transcriptomics analysis., PMID:40104718
Adolescent stress avoidance influences cue-induced heroin seeking and chaperonin gene expression in the dorsal striatum of adult female rats., PMID:40073296
Downregulation of HSPB1 and MGST1 Promotes Ferroptosis and Impacts Immune Infiltration in Diabetic Cardiomyopathy., PMID:40053272
Expression of UCOE and HSP27 Molecular Elements to Improve the Stable Protein Production on HEK293 Cells., PMID:40041570
HSPB1 Orchestrates the Inflammation-Associated Transcriptome Profile of Atherosclerosis in HUVECs., PMID:40018940
Establishment of an alternative splicing prognostic risk model and identification of FN1 as a potential biomarker in glioblastoma multiforme., PMID:40000711
Identifying gene expression and cellular pathways involved in glomerular AL-amyloidosis and correlation with experimental data: seeking novel therapeutic interventions., PMID:39985165
Involvement of the STAT3/HIF-1α signaling pathway in α-synuclein-induced ferroptosis., PMID:39946981
Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux., PMID:39936620
Virtual screening of polyherbal compounds for AKT1 and HSPB1 inhibition in breast cancer apoptosis pathway., PMID:39929029
Targeting the S100A9/P38 MAPK/HSPB1 axis as a novel approach for aortic dissection therapy., PMID:39904041
Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC., PMID:39894886
High-throughput screening of thermal tolerant candidate genes in the ivory shell (Babylonia areolata) based on the yeast strain INVSc1., PMID:39889586
HSP27/IL-6 axis promotes OSCC chemoresistance, invasion and migration by orchestrating macrophages via a positive feedback loop., PMID:39873845
Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer's disease: a bioinformatics and experimental study., PMID:39872979
Key Role of Phosphorylation in Small Heat Shock Protein Regulation via Oligomeric Disaggregation and Functional Activation., PMID:39851555
The prognostic importance of the negative regulators of ferroptosis, GPX4 and HSPB1, in patients with colorectal cancer., PMID:39850719
Interaction of small heat shock proteins with BAG3., PMID:39814164
Down-regulation of HSPB1 and MGST1 promote ferroptosis and impact immune infiltration in diabetic cardiomyopathy., PMID:39711549
Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies., PMID:39698979
Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid-Liquid Phase Separation and Ferroptosis-Related Genes., PMID:39635757
[Hepatic T cell subtypes and functional analysis among alveolar echinococcosis patients using single-cell RNA sequencing]., PMID:39623989
Effect of Short-Term Restraint Stress on the Expression of Genes Associated with the Response to Oxidative Stress in the Hypothalamus of Hypertensive ISIAH and Normotensive WAG Rats., PMID:39594444
THE DICHOTOMY BETWEEN HEAT SHOCK PROTEIN-27 AND MICROALBUMIN: COVARIATE OF EARLY DIABETIC NEPHROPATHY., PMID:39585256
Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27., PMID:39541976
[Effect of phosphorylated HSP27 on the proliferation and metastasis of nasopharyngeal carcinoma and its mechanism]., PMID:39534892
Comparative meta-analysis of transcriptomic studies in spinal muscular atrophy: comparison between tissues and mouse models., PMID:39529156
Promising predictors of diabetic peripheral neuropathy in children and adolescents with type 1 diabetes mellitus., PMID:39402605
Luteolin target HSPB1 regulates endothelial cell ferroptosis to protect against radiation vascular injury., PMID:39392831
Role of vitamin E on bovine skeletal-muscle-derived cells from Korean native cattle under heat treatment., PMID:39383093
For research use only. Not for human or drug use.
