Catalog No.
YHC10101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala61
Predicted molecular weight
8.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04731
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MT1S, Metallothionein-IA, MT-IA, Metallothionein-1A, MT-1A, MT1A
Prenatal Constant Light Exposure Induces Behavioral Deficits in Male and Female Rat Offspring: Effects of Prenatal Melatonin Treatment., PMID:39940805
Metallothionein-1A (MT1A) Gene Variability May Play a Role in Female Frailty: A Preliminary Study., PMID:39858562
Identification of genes contributing to attenuation of rat model of galactose-induced cataract by pyruvate., PMID:39219252
Cadmium exposure and its association with oxidative stress, MT1A methylation, and idiopathic male infertility in Egypt: A case-control study., PMID:39142552
ESI-MS analysis of Cu(I) binding to apo and Zn7 human metallothionein 1A, 2, and 3 identifies the formation of a similar series of metallated species with no individual isoform optimization for Cu(I)., PMID:38503570
scRNA-seq analysis discovered suppression of immunomodulatory dependent inflammatory response in PMBCs exposed to silver nanoparticles., PMID:38494495
Influence of copper source and dietary inclusion level on growth performance of weaned pigs and expression of trace element related genes in the small intestine., PMID:38492538
Human apo-metallothionein 1a is not a random coil: Evidence from guanidinium chloride, high temperature, and acidic pH unfolding studies., PMID:38490456
Bi(III) Binding Stoichiometry and Domain-Specificity Differences Between Apo and Zn(II)-bound Human Metallothionein 1a., PMID:38356034
Protective Effect of the Novel Melatonin Analogue Containing Donepezil Fragment on Memory Impairment via MT/ERK/CREB Signaling in the Hippocampus in a Rat Model of Pinealectomy and Subsequent Aβ1-42 Infusion., PMID:38339146
Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms., PMID:37804870
An Assessment of MT1A (rs11076161), MT2A (rs28366003) and MT1L (rs10636) Gene Polymorphisms and MT2 Concentration in Women with Endometrial Pathologies., PMID:36981043
Melatonin Supports the Survival of Cholinergic Neurons in Organotypic Brain Slices of the Basal Nucleus of Meynert., PMID:36724742
The Difference in Zinc Concentrations Required for Induction among Metallothionein Isoforms Can Be Explained by the Different MTF1 Affinities to MREs in Its Promoter., PMID:36613726
63Cu(I) binding to human kidney 68Zn7-βα MT1A: determination of Cu(I)-thiolate cluster domain specificity from ESI-MS and room temperature phosphorescence spectroscopy., PMID:36583699
Intake of mother's milk by very-low-birth-weight infants and variation in DNA methylation of genes involved in neurodevelopment at 5.5 years of age., PMID:35977396
Metallothioneins in Dental Implant Treatment Failure and Periodontitis in Patients with Down's Syndrome: Validation of Results., PMID:35741790
Targeted Analysis of Tears Revealed Specific Altered Metal Homeostasis in Age-Related Macular Degeneration., PMID:35426907
Oxidative Stress in Dairy Cows: Insights into the Mechanistic Mode of Actions and Mitigating Strategies., PMID:34943022
Zinc Inhibits Cadherin 1 Expression Induced by 1α,25-Dihydroxyvitamin D3 in Colon Cancer Cells., PMID:34732414
Role of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA)., PMID:34326641
Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease., PMID:34297416
Content of total aflatoxin, lead, and cadmium in the bovine meat and edible offal: study of their human dietary intake, health risk assessment, and molecular biomarkers., PMID:34170471
Importance of Genetic Polymorphisms in MT1 and MT2 Genes in Metals Homeostasis and Their Relationship with the Risk of Acute Pancreatitis Occurrence in Smokers-Preliminary Findings., PMID:34072023
Effects of Androgen Receptor Inhibition on Kanamycin-Induced Hearing Loss in Rats., PMID:34070066
Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models., PMID:33839236
Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population., PMID:33340085
Induction of metallothionein isoforms in cultured bovine aortic endothelial cells exposed to cadmium., PMID:33268680
The pathways and domain specificity of Cu(I) binding to human metallothionein 1A., PMID:33225329
Corneal tissue induces transcription of metallothioneins in monocyte-derived human macrophages., PMID:33137607
Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma., PMID:33122816
Expression profiles of metallothionein-I/II and megalin/LRP-2 in uterine cervical squamous lesions., PMID:33084977
Effect of metallothionein 1A rs8052394 polymorphism on lead, cadmium, zinc, and aluminum levels in factory workers., PMID:32816651
The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms., PMID:32541800
Association between genetic variations in GSH-related and MT genes and low-dose methylmercury exposure in children and women of childbearing age: a pilot study., PMID:32480025
Transcriptomic profiles reveal differences in zinc metabolism, inflammation, and tight junction proteins in duodenum from cholesterol gallstone subjects., PMID:32366946
Effects of Vitamin D Receptor, Metallothionein 1A, and 2A Gene Polymorphisms on Toxicity of the Peripheral Nervous System in Chronically Lead-Exposed Workers., PMID:32340109
Metallothionein Cd4S11 cluster formation dominates in the protection of carbonic anhydrase., PMID:32219259
Altered secretory and neuroprotective function of the choroid plexus in progressive multiple sclerosis., PMID:32192527
Distinct host-immune response toward species related intracellular mycobacterial killing: A transcriptomic study., PMID:32052695
pH dependence of the non-cooperative binding of Bi3+ to human apo-metallothionein 1A: kinetics, speciation, and stoichiometry., PMID:32031554
Reduced hepatic metallothionein expression in first trimester fetuses in response to intrauterine smoking exposure: a consequence of low maternal zinc levels?, PMID:31713610
Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear., PMID:31561736
Metallothioneins in Failure of Dental Implants and Periodontitis Down Syndrome Patients., PMID:31540037
Association of Genetic Variations in NRF2, NQO1, HMOX1, and MT with Severity of Coronary Artery Disease and Related Risk Factors., PMID:31332605
The role of zinc supplementation on the metallothionein system in children with autism spectrum disorder., PMID:31302864
Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells., PMID:31068538
Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival., PMID:30932010
Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells., PMID:30884885
Cancer-related gene expression is associated with disease severity and modifiable lifestyle factors in non-alcoholic fatty liver disease., PMID:30870804
For research use only. Not for human or drug use.
