Catalog No.
YHC09901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser268
Predicted molecular weight
55.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04632
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CAPN4, CAPNS1, Calpain regulatory subunit, Calcium-dependent protease small subunit 1, Calcium-dependent protease small subunit, Calcium-activated neutral proteinase small subunit, CDPS, CSS1, Calpain small subunit 1, CANP small subunit, CAPNS
In Silico Screening for Small Molecules to Alter Calpain Proteolysis through Modulating Conformation Changes Induced by Heterodimerization., PMID:40392912
Quantification and structure-function analysis of calpain-1 and calpain-2 protease subunit interactions., PMID:40383147
Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection., PMID:40171827
Cereblon mediates macrophage differentiation and microglial phagocytosis by regulating calpain protease activity., PMID:39454366
Integrative analysis of autophagy-related genes reveals that CAPNS1 is a novel prognostic biomarker and promotes the malignancy of melanoma via Notch signaling pathway., PMID:39267668
The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis., PMID:39207047
Testing calpain inhibition in tumor endothelial cells: novel targetable biomarkers against glioblastoma malignancy., PMID:39156707
Systematic selection of suitable reference genes for quantitative real-time PCR normalization studies of gene expression in Lutjanus erythropterus., PMID:38858385
Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer., PMID:38800011
Deep Learning Techniques to Characterize the RPS28P7 Pseudogene and the Metazoa-SRP Gene as Drug Potential Targets in Pancreatic Cancer Patients., PMID:38397997
The neuronal transcription factor MEIS2 is a calpain-2 protease target., PMID:38305737
Biallelic variants in the calpain regulatory subunit CAPNS1 cause pulmonary arterial hypertension., PMID:38230350
Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1., PMID:38057394
Enhanced ileum function in weaned piglets via Laminaria digitata and alginate lyase dietary inclusion: A combined proteomics and metabolomics analysis., PMID:37775079
A Study on Autophagy Related Biomarkers in Alzheimer's Disease Based on Bioinformatics., PMID:37418137
Chopped fibers and nano-hydroxyapatite enhanced silk fibroin porous hybrid scaffolds for bone augmentation., PMID:36692356
Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis., PMID:35729674
Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis., PMID:35447117
Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets., PMID:35421970
Proteomic profiling of postmortem prefrontal cortex tissue of suicide completers., PMID:35383147
Identification of Crucial Genes and Key Functions in Type 2 Diabetic Hearts by Bioinformatic Analysis., PMID:35242109
Calpain-mediated protein targets in cardiac mitochondria following ischemia-reperfusion., PMID:34997008
Capn4 aggravates angiotensin II-induced cardiac hypertrophy by activating the IGF-AKT signalling pathway., PMID:34580724
Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy., PMID:34524407
DNA polymerase η is a substrate for calpain: a possible mechanism for pol η retention in UV-induced replication foci., PMID:34080634
Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death., PMID:33964876
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma., PMID:33887737
Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA‑1271‑mediated Capn4/Wnt/β‑catenin signaling pathway in epithelial ovarian cancer., PMID:33760208
Proteome Composition of Bovine Amniotic Membrane and Its Potential Role in Corneal Healing., PMID:33560292
Calpain-calpastatin system and cancer progression., PMID:33470511
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury., PMID:33208557
Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways., PMID:32989050
Synthesis of α-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents., PMID:32840034
Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/β-catenin/MMP9 signalling pathways., PMID:32777225
Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy., PMID:32348180
Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production., PMID:32346126
P38α-MAPK Signaling Inhibition Attenuates Soleus Atrophy during Early Stages of Muscle Unloading., PMID:32326654
Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation., PMID:32083121
A novel nicastrin mutation in a three-generation Dutch family with hidradenitis suppurativa: a search for functional significance., PMID:32078194
Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload., PMID:32061585
Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder., PMID:31801218
Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling., PMID:31691433
Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis., PMID:30778623
Genetic Models of Calpain Deficiency and Ectopic Expression., PMID:30617810
MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4., PMID:30452399
Calpain system protein expression and activity in ovarian cancer., PMID:30448882
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/β-catenin signaling pathway., PMID:30444080
Capn4 expression is modulated by microRNA-520b and exerts an oncogenic role in prostate cancer cells by promoting Wnt/β-catenin signaling., PMID:30241050
Proteomics study of serum exosomes from papillary thyroid cancer patients., PMID:29895528
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway., PMID:29648579
For research use only. Not for human or drug use.
