Catalog No.
AHE32201
Biological activity
Measured by its ability to inhibit BMP-4-induced activity in mouse preosteoblast cells (MC3T3‑E1). The ED50 for this effect is 0.2-1 µg/mL in the presence of 50 ng/mL of rhBMP-4.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala17-Asp181
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P41271
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein N03, Neuroblastoma suppressor of tumorigenicity 1, DAND1, DAN domain family member 1, Zinc finger protein DAN, NBL1, DAN
Note
For research use only.
The DAN family: modulators of TGF-β signaling and beyond., PMID:24810382
Glycoprotein hormones and their receptors emerged at the origin of metazoans., PMID:24904013
Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis., PMID:25545425
Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists., PMID:25561725
Trichinella spiralis newborn larvae: characterization of a stage specific serine proteinase expression, NBL1, using monoclonal antibodies., PMID:25597315
Necrotizing enterocolitis as an adverse effect of recombinant interleukin-2 and Ch14.18 in maintenance therapy for high-risk neuroblastoma., PMID:25730142
Identification and characterization of immunodominant linear epitopes on the antigenic region of a serine protease in newborn Trichinella larvae., PMID:25989815
Differential screening-selected gene aberrative in neuroblastoma (DAN) is increased in the CSF of patients with MS and may be induced by therapy with interferon-β., PMID:26943965
Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFβ-p38MAPK pathway., PMID:27474499
Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism., PMID:27524626
Lhx8 interacts with a novel germ cell-specific nuclear factor containing an Nbl1 domain in rainbow trout (Oncorhynchus mykiss)., PMID:28151980
Preclinical development of a humanized neutralizing antibody targeting HGF., PMID:28336956
A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis., PMID:28754723
DAN (NBL1) promotes collective neural crest migration by restraining uncontrolled invasion., PMID:28811280
Chromosome passenger complex is required for the survival of cells with ring chromosomes in fission yeast., PMID:29298360
Circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1): A potential biomarker for coronary artery disease in patients with obstructive sleep apnea., PMID:29596467
Risk stratification of high-risk metastatic neuroblastoma: A report from the HR-NBL-1/SIOPEN study., PMID:30015396
Ancestry and genetic associations with bronchopulmonary dysplasia in preterm infants., PMID:30113228
Interleukin 2 plus anti-GD2 immunotherapy: helpful or harmful?, PMID:30442498
Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial., PMID:30442501
Gingival fibroblasts prevent BMP-mediated osteoblastic differentiation., PMID:30511378
New Insights into the Mechanism of NO3- Selectivity in the Human Kidney Chloride Channel ClC-Ka and the CLC Protein Family., PMID:30635372
Grem2 mediates podocyte apoptosis in high glucose milieu., PMID:30831151
Transcriptomic analysis of female and male gonads in juvenile snakeskin gourami (Trichopodus pectoralis)., PMID:32251302
Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST., PMID:32779697
A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high-risk neuroblastoma: An International Neuroblastoma Risk Group project., PMID:33205902
OsNBL1, a Multi-Organelle Localized Protein, Plays Essential Roles in Rice Senescence, Disease Resistance, and Salt Tolerance., PMID:33423130
Survival in patients with high-risk neuroblastoma treated without autologous stem cell transplant or dinutuximab beta., PMID:33622164
Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1)., PMID:34115544
Expression profiling of ovarian BMP antagonists reveals the potential interaction between TWSG1 and the chordin subfamily in the ovary., PMID:34517078
Evolution of the DAN gene family in vertebrates., PMID:34902310
Acute serum protein and cytokine response of single dose of prednisone in adult volunteers., PMID:35026285
A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host's cell vimentin., PMID:35320836
Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes., PMID:35947673
Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype., PMID:36167601
Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease., PMID:36169661
Deep next-generation proteomics and network analysis reveal systemic and tissue-specific patterns in Fabry disease., PMID:36863609
A new layer of regulation of chromosomal passenger complex (CPC) translocation in budding yeast., PMID:37405742
Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy., PMID:37436574
Sensitive Quantitative In Vivo Assay for Evaluating the Effects of Biomolecules on Hair Growth and Coloring Using Direct Microinjections into Mouse Whisker Follicles., PMID:37509112
miR-1301-3p promotes invasion and migration and EMT progression in esophageal cancer by downregulating NBL1 expression., PMID:37680006
Integrative analysis of cuproptosis-associated genes for predicting immunotherapy response in single-cell and multi-cohort studies., PMID:37776237
Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes., PMID:37794117
NBL1 Reduces Corneal Fibrosis and Scar Formation after Wounding., PMID:38002252
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size., PMID:38019897
Tibetan mesenchymal stem cell-derived exosomes alleviate pulmonary vascular remodeling in hypoxic pulmonary hypertension rats., PMID:38717187
Small RNA sequencing reveals snoRNAs and piRNA-019825 as novel players in diabetic kidney disease., PMID:38801599
Identifying Biomarkers of Neuroplasticity Associated with Exercise-Induced Cognitive Change in Older Adults with MCI., PMID:40017026
Impact of Static Myoblast Loading on Protein Secretion Linked to Tenocyte Migration., PMID:40202163
Single-molecule tracking reveals the dynamic turnover of Ipl1 at the kinetochores in Saccharomyces cerevisiae., PMID:40250989
For research use only. Not for human or drug use.
