Catalog No.
EHC08001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln73-Met232
Predicted molecular weight
20.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04233
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HLA-DR antigens-associated invariant chain, HLA class II histocompatibility antigen gamma chain, CD74, CLIP, Ia antigen-associated invariant chain, DHLAG, Ii
The multifaced role of the macrophage-migration-inhibitory-factor (MIF)-family in organ fibrosis., PMID:40445596
MIF regulates T helper 17 cell differentiation by activating the p38 MAPK signaling pathway to drive the pathogenesis of EAP., PMID:40440956
Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets., PMID:40427533
The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism., PMID:40411322
Targeting CD74 in microglia to modulate experimental cerebral ischemia and reperfusion injury: insights from Single-Cell and bulk transcriptomics., PMID:40400029
SCGB3A1-Epi and KLK10-Epi Crosstalk With Fibroblasts Promotes Liver Metastasis of Breast Cancer and Pancreatic Ductal Adenocarcinoma., PMID:40357856
Lysine-specific demethylase 1 deletion reshapes tumour microenvironment to overcome acquired resistance to anti-programmed death 1 therapy in liver cancer., PMID:40356247
Integration of Single-Cell RNA Sequencing Data and Bulk Sequencing Data to Characterise the CD8+ T-Cell Exhaustion Mediated Immune Microenvironment in CRC., PMID:40356050
Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia., PMID:40352549
Interferon gamma-induced hub genes and key pathways: A study based on biological network analysis and experimental validation., PMID:40348089
Integration of bulk RNA-seq and scRNA-seq reveals transcriptomic signatures associated with deep vein thrombosis., PMID:40342960
The cancer stem cells characteristics analysis of LGR5 + cells that influence lung cancer risk by using single cell RNA-seq analysis., PMID:40341189
Single-cell RNA sequencing and spatial transcriptomics reveal unique subpopulations of infiltrating macrophages and dendritic cells following AKI., PMID:40331777
Exploring the role of the CD74+ cardiac macrophage subset in trastuzumab cardiotoxicity and its mechanisms., PMID:40316056
Case Report: A case of first-line treatment for rare ROS1 fusion mutation lung adenocarcinoma with entrectinib., PMID:40308505
An In-Silico Study to Identify Relevant Biomarkers in Sepsis Applying Integrated Bulk RNA Sequencing and Single-Cell RNA Sequencing Analyses., PMID:40255236
Association of interferon regulator factor 1 upregulation with pulmonary arterial hypertension., PMID:40223959
CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis., PMID:40185975
Computational network biology analysis revealed COVID-19 severity markers: Molecular interplay between HLA-II with CIITA., PMID:40163554
Single-Cell Transcriptomics Identifies a Prominent Role for the MIF-CD74 Axis in Myasthenia Gravis Thymus., PMID:40117520
Novel Identification of CD74 as a Biomarker for Diagnosing and Prognosing Sepsis Patients., PMID:40115322
The IFN-high phenotype: A biomarker-driven breakthrough in colorectal cancer treatment., PMID:40107241
Combination therapy with Chicoric acid and PD-1/PD-L1 blockade improves the immunotherapy response in patient-derived ovarian cancer xenograft model., PMID:40087780
Anti-CD74 autoantibodies in axial spondyloarthritis as biomarkers for activity and severity of disease but not for tumour necrosis factor inhibitor retention: data from the Swiss Clinical Quality Management in rheumatic diseases cohort., PMID:40063233
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis., PMID:40055309
Large-Scale Plasma Proteomics to Profile Pathways and Prognosis of Chronic Pain., PMID:40048323
Transcriptomics and microbiome insights reveal the protective mechanism of mulberry-derived postbiotics against inflammation in LPS-induced mice., PMID:40040706
Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CX3CR1+ synovial lining macrophage barrier., PMID:40038808
Preclinical in vitro and in vivo evidence for targeting CD74 as an effective treatment strategy for cutaneous T-cell lymphomas., PMID:40036608
Differentiation of human hyalocytes from induced pluripotent stem cells through ascorbic acid treatment., PMID:39937308
HIF1α/MIF/CD74 signaling mediated OSA-induced atrial fibrillation by promoting M1 macrophages polarization., PMID:39929098
Transcriptomic profiles of single-cell autophagy-related genes (ATGs) in lung diseases., PMID:39920481
Ibudilast Protects Retinal Bipolar Cells From Excitotoxic Retinal Damage and Activates the mTOR Pathway., PMID:39916387
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes., PMID:39915484
Distinctive Macrophage Migration Inhibitory Factor Receptor Patterns and Soluble Biomarkers in Rheumatoid Arthritis: Unveiling Key Associations with Disease Activity., PMID:39914814
Acquired RUFY1-RET rearrangement as a mechanism of resistance to lorlatinib in a patient with CD74-ROS1 rearranged non-small cell lung cancer: A case report., PMID:39907599
IL-8 contributes to functional diversity of tumor-infiltrating neutrophils: A new target for cancer immunotherapy., PMID:39904319
Characteristics of TSPO expression in marmoset EAE., PMID:39871344
Osteopontin Facilitated Dental Pulp Cell Adhesion and Differentiation: A Laboratory Investigation., PMID:39865657
A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer., PMID:39824178
The CD74 inhibitor DRhQ improves short-term memory and mitochondrial function in 5xFAD mouse model of Aβ accumulation., PMID:39808341
Integrative analysis of Ewing's sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy., PMID:39800691
ANXA10 sensitizes microsatellite instability-high colorectal cancer to anti-PD-1 immunotherapy via assembly of HLA-DR dimers by regulating CD74., PMID:39789407
Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1-familial platelet disorder., PMID:39772771
Keratinocyte-Mediated Antigen Presentation in Psoriasis: Preliminary Insights from In Vitro Studies., PMID:39769151
MIF/CD74 axis in hepatic stellate cells mediates HBV-related liver fibrosis., PMID:39752755
System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans., PMID:39747435
Transcriptional analysis reveals the suppression of RAD51 and disruption of the homologous recombination pathway during PEDV infection in IPEC-J2 cells., PMID:39731192
Integrative multi-omics analysis reveals a novel subtype of hepatocellular carcinoma with biological and clinical relevance., PMID:39712016
Spatial transcriptome profiling identifies DTX3L and BST2 as key biomarkers in esophageal squamous cell carcinoma tumorigenesis., PMID:39696540
For research use only. Not for human or drug use.
