Catalog No.
AHD48301
Biological activity
Measured by the ability of the immobilized protein to induce IFN gamma secretion in human natural killer lymphoma cells (NK‑92). The ED50 for this effect is 3-15 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg117-Asp359
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P21854
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD72, Lyb-2, B-cell differentiation antigen CD72
Note
For research use only.
Receptor Functions of Semaphorin 4D., PMID:31693461
Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia., PMID:31708102
Differential expression of immune-related genes in the bursa of Fabricius of two inbred chicken lines following infection with very virulent infectious bursal disease virus., PMID:31837598
CD22 and CD72 contribute to the development of scleroderma in a murine model., PMID:31883832
[Relapsing-remitting multiple sclerosis: clinical and immunological aspects of the pathology on the example Sema4D and CD72]., PMID:31934990
Insufficient CD100 shedding contributes to suppression of CD8+ T-cell activity in non-small cell lung cancer., PMID:32149403
A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome., PMID:32306893
Increased levels of inflammatory markers in the subscapularis tendon and joint capsule in patients with subacromial impingement., PMID:32356046
CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case-control study., PMID:32700598
Efficient Expansion of Human Granzyme B-Expressing B Cells with Potent Regulatory Properties., PMID:32948686
Semaphorin 4D Induces an Imbalance of Th17/Treg Cells by Activating the Aryl Hydrocarbon Receptor in Ankylosing Spondylitis., PMID:33013906
The emerging roles of semaphorin4D/CD100 in immunological diseases., PMID:33258873
Myeloid-like γδ T cell subset in the immune response to an experimental Rift Valley fever vaccine in sheep., PMID:33454621
Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL., PMID:33727310
Semaphorin 4D as a guidance molecule in the immune system., PMID:33787446
Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury., PMID:34100920
Dermatan Sulfate Is a Potential Regulator of IgH via Interactions With Pre-BCR, GTF2I, and BiP ER Complex in Pre-B Lymphoblasts., PMID:34113352
[Relapsing-remitting multiple sclerosis: clinical and immunological aspects of the pathology on the example of molecules Sema4D and CD72]., PMID:34387451
Aberrant expression of inhibitory receptors on B cells in patients with Graves' disease., PMID:34933777
Role of inhibitory B cell co-receptors in B cell self-tolerance to non-protein antigens., PMID:34989000
Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis., PMID:35328359
Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis., PMID:35628440
Blockage of CD72 reduces B cell proliferation in immune thrombocytopenic purpura, involving interleukin 1 and macrophage migration inhibitory factor secretion., PMID:36326455
Regulation of B cell receptor signalling by Epstein-Barr virus nuclear antigens., PMID:36383217
CD72-semaphorin3A axis: A new regulatory pathway in systemic lupus erythematosus., PMID:36470209
Naturally selected CD7 CAR-T therapy without genetic editing demonstrates significant antitumour efficacy against relapsed and refractory acute myeloid leukaemia (R/R-AML)., PMID:36517851
The Differentially Expressed Genes Responsible for the Development of T Helper 9 Cells From T Helper 2 Cells in Various Disease States: Immuno-Interactomics Study., PMID:38935935
Phosphorylation stabilized TET1 acts as an oncoprotein and therapeutic target in B cell acute lymphoblastic leukemia., PMID:36989375
Oncolytic attenuated measles virus encoding NY-ESO-1 induces HLA I and II presentation of this tumor antigen by melanoma and dendritic cells., PMID:37466668
Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection., PMID:37638016
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice., PMID:37695523
CD72 is a pan-tumor antigen associated to pediatric acute leukemia., PMID:37876342
CD72, a new immune checkpoint molecule, is a novel prognostic biomarker for kidney renal clear cell carcinoma., PMID:37980541
Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies., PMID:38007238
Physiological regulation of microalgae under cadmium stress and response mechanisms of time-series analysis using metabolomics., PMID:38262539
A phase 1/2 study of pepinemab in children, adolescents, or young adults with recurrent or refractory solid tumors: A children's oncology group consortium report (ADVL1614)., PMID:38520670
Asiaticoside alleviates lipopolysaccharide-induced acute lung injury by blocking Sema4D/CD72 and inhibiting mitochondrial dysfunction in RAW264.7 cell and mice., PMID:38664244
CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody., PMID:38754236
Differential Gene Expression Involved in Bone Turnover of Mice Expressing Constitutively Active TGFβ Receptor Type I., PMID:38892016
Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity., PMID:39026665
A Predictive Model for Initial Platinum-Based Chemotherapy Efficacy in Patients with Postoperative Epithelial Ovarian Cancer Using Tissue-Derived Small Extracellular Vesicles., PMID:39104279
Novel Immunotherapy Targets for Relapsed/Refractory B-ALL: A Literature Review., PMID:39222522
Characterization of prostate macrophage heterogeneity, foam cell markers, and CXCL17 upregulation in a mouse model of steroid hormone imbalance., PMID:39251671
Elucidation of mechanisms underlying active oxygen burst in Citrus sinensis after Diaporthe citri infection using transcriptome analysis., PMID:39268534
Soluble CD72 concurrently impairs T cell functions while enhances inflammatory response in sepsis., PMID:39793226
Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study., PMID:39974069
A cohort of highly activated CD99- CD72+ B cells promoting autoimmune progression in juvenile systemic lupus erythematosus., PMID:40090085
Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study., PMID:40344339
DBI as a Novel Immunotherapeutic Candidate in Colorectal Cancer: Dissecting Genetic Risk and the Immune Landscape via GWAS, eQTL, and pQTL., PMID:40426943
Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling., PMID:40501958
For research use only. Not for human or drug use.
