Catalog No.
YHC07201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe25-Glu440
Predicted molecular weight
49.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04180
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Platelet-activating factor acetylhydrolase, Phosphatidylcholine-sterol acyltransferase, Phospholipid-cholesterol acyltransferase, PAF acetylhydrolase, LCAT, 1-alkyl-2-acetylglycerophosphocholine esterase, Lecithin-cholesterol acyltransferase
Metabolic reprogramming in hepatocellular carcinoma: an integrated omics study of lipid pathways and their diagnostic potential., PMID:40500772
Diagnostic significance of clinical scoring system and serum lipid profiles as recovery indicators in ketotic dairy cattle using hormonal-steroids-carbohydrates therapeutic protocol., PMID:40453841
Serum levels of advanced glycation end products negatively correlates with activity of Paraoxonase1 and Lecithin-Cholesterol Acyltransferase in diabetic retinopathy; A cross-sectional case-control study., PMID:40187629
Lecithin:cholesterol acyltransferase binds a discontinuous binding site on adjacent apolipoprotein A-I belts in HDL., PMID:40147634
Regulation of CNS Lipids by Protease Activated Receptor 1., PMID:40123504
Proteomics-driven discovery of LCAT as a novel biomarker for liver metastasis in colorectal cancer., PMID:40089671
Variations in rumen microbiota and host genome impacted feed efficiency in goat breeds., PMID:39944650
Therapeutic effect and potential mechanism of Fufang Danshen dripping pills for stable coronary heart disease: a randomized controlled trial., PMID:39944604
HDL proteome and apolipoproteins concentrations in severe ICU COVID-19 patients., PMID:39891286
LCAT deficiency promotes hepatocellular carcinoma progression and lenvatinib resistance by promoting triglyceride catabolism and fatty acid oxidation., PMID:39842501
Identifying Biomarkers for Atherosclerosis via Gene Expression and Biological Networking., PMID:39773060
First-episode mild depression in young adults is a pre-proatherogenic condition even in the absence of subclinical metabolic syndrome: lowered lecithin-cholesterol acyltransferase as a key factor., PMID:39737498
A Rare Case of Autoimmune-Mediated Lecithin:Cholesterol Acyltransferase Insufficiency Manifesting as the Acute Onset of Extremely Hypo-High-Density Lipoprotein-Cholesterolemia and Spontaneous Improvement: A Case Report with a Review of the Literature., PMID:39662947
Multi-omics analysis reveals the protective effects of Chinese yam polysaccharide against cisplatin-induced renal interstitial fibrosis., PMID:39603894
Novel pathogenic variant in the LCAT gene in a compound heterozygous patient with fish-eye disease and a mild phenotype., PMID:39537502
UNCONTROLLED TYPE 2 DIABETES MELLITUS MODULATED PLASMA LEVELS OF LIPID CATABOLIC PROTEINS., PMID:39441301
Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid., PMID:39342078
Effects of dietary interventions and intermittent fasting on HDL function in obese individuals with T2DM: a randomized controlled trial., PMID:39267053
Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients., PMID:39244794
A Novel Symptomatic Lecithin-Cholesterol Acyltransferase Gene Mutation With Corneal Amyloidosis., PMID:39177400
Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis., PMID:39171187
Low LCAT activity is linked to acute decompensated heart failure and mortality in patients with CKD., PMID:39154733
Rescue of Familial Lecithin:Cholesterol Acyltranferase Deficiency Mutations with an Allosteric Activator., PMID:39151949
Identification of Potential Drug Targets for Myopia Through Mendelian Randomization., PMID:39110588
ADH4-a potential prognostic marker for hepatocellular carcinoma with possible immune-related implications., PMID:39090641
Discovery of candidate biomarkers from plasma-derived extracellular vesicles of patients with cirrhosis and hepatocellular carcinoma: an exploratory proteomic study., PMID:39011654
Identification and Molecular Simulation of Genetic Variants in ABCA1 Gene Associated with Susceptibility to Dyslipidemia in Type 2 Diabetes., PMID:38928502
ALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification., PMID:38918701
Differentiation between descending thoracic aortic diseases using machine learning and plasma proteomic signatures., PMID:38825704
Systematic evaluation of lecithin:cholesterol acyltransferase binding sites in apolipoproteins via peptide based nanodiscs: regulatory role of charged residues at positions 4 and 7., PMID:38805510
Estrogen Induces LCAT to Maintain Cholesterol Homeostasis and Suppress Hepatocellular Carcinoma Development., PMID:38718297
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans., PMID:38695168
Identification and functional analysis of lactic acid metabolism-related differentially expressed genes in hepatocellular carcinoma., PMID:38689649
Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice., PMID:38629368
Co-administration of "L-Lysine, Vitamin C, and Zinc" increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats., PMID:38599057
The anti-hyperlipidemia effect of Atractylodes macrocephala Rhizome increased HDL via reverse cholesterol transfer., PMID:38560167
Familial LCAT Deficiency and Low HDL-C Levels: In silico Characterization of Two Rare LCAT Missense Mutations., PMID:38404612
A High-Throughput NMR Method for Lipoprotein-X Quantification., PMID:38338310
Betaine supplementation alleviates corticosterone-induced hepatic cholesterol accumulation through epigenetic modulation of HMGCR and CYP7A1 genes in laying hens., PMID:38232620
A novel cholesterol metabolism-related ferroptosis pathway in hepatocellular carcinoma., PMID:38191842
Seasonal Factors Are Associated with Activities of Enzymes Involved in High-Density Lipoprotein Metabolism among Pregnant Females in Ghana., PMID:38130330
Flipped C-Terminal Ends of APOA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs., PMID:38018436
Flipped C-Terminal Ends of APOA1 Promote ABCA1-dependent Cholesterol Efflux by Small HDLs., PMID:37961344
Targeting DNA methylation in diabetic kidney disease: A new perspective., PMID:37949210
Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level., PMID:37923248
Dietary proteins modulate high-density lipoprotein characteristics in a sex-specific way in Apoe-deficient mice., PMID:37812855
Characterization of feed efficiency-related key signatures molecular in different cattle breeds., PMID:37756351
Impaired Reverse Cholesterol Transport is Associated with Changes in Fatty Acid Profile in Children and Adolescents with Abdominal Obesity., PMID:37716606
Discovery of age-related early-stage glycated proteins based on deep quantitative serum glycated proteome analysis., PMID:37654074
Integrated proteomic and metabolomic analysis of plasma reveals regulatory pathways and key elements in thyroid cancer., PMID:37642188
For research use only. Not for human or drug use.
