Catalog No.
PHE92201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human MAP2K6 (Phe46-Pro306).
Target
MEK6, Dual specificity mitogen-activated protein kinase kinase 6, SAPKK-3, PRKMK6, MAPK/ERK kinase 6, Stress-activated protein kinase kinase 3, MAP2K6, SKK3, MKK6, MAPKK 6, SAPKK3, MEK 6, MAP kinase kinase 6, SAPK kinase 3
Purification
Antigen affinity purification.
Accession
P52564
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis., PMID:38195995
CCL20 induced by visfatin in macrophages via the NF-κB and MKK3/6-p38 signaling pathways contributes to hepatic stellate cell activation., PMID:32418112
Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model., PMID:27467592
TAT-OSBP-1-MKK6(E), a novel TAT-fusion protein with high selectivity for human ovarian cancer, exhibits anti-tumor activity., PMID:25782870
Blockade of CD26 signaling inhibits human osteoclast development., PMID:24821427
Stress-activated kinase pathway alteration is a frequent event in bladder cancer., PMID:22154358
Potential characteristics of stem cells from human exfoliated deciduous teeth compared with bone marrow-derived mesenchymal stem cells for mineralized tissue-forming cell biology., PMID:22099898
Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice., PMID:21953132
ß-Elemene inhibits proliferation of human glioblastoma cells and causes cell-cycle G0/G1 arrest via mutually compensatory activation of MKK3 and MKK6., PMID:21132268
Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients., PMID:20805296
Molecular characterization of young and mature odontoblasts., PMID:19555781
Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments., PMID:18684326
Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism., PMID:18413810
Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation., PMID:17214902
Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse., PMID:16565401
Phosphorylation of serine 526 is required for MEKK3 activity, and association with 14-3-3 blocks dephosphorylation., PMID:16407301
15S-Lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK., PMID:16000313
Transforming growth factor (TGF)-beta-activated kinase 1 mimics and mediates TGF-beta-induced stimulation of type II collagen synthesis in chondrocytes independent of Col2a1 transcription and Smad3 signaling., PMID:15743758
p38 MAPK is a critical regulator of the constitutive and the beta4 integrin-regulated expression of IL-6 in human normal thymic epithelial cells., PMID:14579272
The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway., PMID:12170268
Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization., PMID:12149431
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2., PMID:11279118
Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus., PMID:11163400
Inhibition of p38 mitogen-activated protein kinase augments lipopolysaccharide-induced cell proliferation in CD14-expressing Chinese hamster ovary cells., PMID:11159988
Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase., PMID:11134332
Marathon running transiently increases c-Jun NH2-terminal kinase and p38 activities in human skeletal muscle., PMID:10922016
Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades., PMID:9841871
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6., PMID:9430721
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2., PMID:8900184
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3., PMID:8663074
For research use only. Not for human or drug use.
