Catalog No.
RHE14805
Species reactivity
Human
Host species
Mouse
Isotype
VHH-mFc
Clonality
Monoclonal
Target
Wilson disease-associated protein, Copper pump 2, WND, PWD, WC1, Copper-transporting ATPase 2, ATP7B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P35670
Applications
ELISA, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
2R50
Note
For research use only.
Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network., PMID:9147644
Two forms of Wilson disease protein produced by alternative splicing are localized in distinct cellular compartments., PMID:9307043
Intracellular distribution of the Wilson's disease gene product (ATPase7B) after in vitro and in vivo exogenous expression in hepatocytes from the LEC rat, an animal model of Wilson's disease., PMID:9500710
Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases., PMID:9813047
Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?, PMID:9837819
Immunohistochemical determination of the Wilson Copper-transporting P-type ATPase in the brain tissues of the rat., PMID:10336172
Intracellular localization of the Menkes and Wilson's disease proteins and their role in intracellular copper transport., PMID:10453201
Copper-dependent trafficking of Wilson disease mutant ATP7B proteins., PMID:10942420
Copper does not alter the intracellular distribution of ATP7B, a copper-transporting ATPase., PMID:10973814
Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion., PMID:10982773
A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates., PMID:11231950
[A study of gene products encoded by Wilson disease gene]., PMID:11350685
Functional analysis of the sheep Wilson disease protein (sATP7B) in CHO cells., PMID:11432725
Copper-regulated trafficking of the Menkes disease copper ATPase is associated with formation of a phosphorylated catalytic intermediate., PMID:12228238
Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human oral squamous cell carcinoma treated with cisplatin., PMID:12509969
Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma., PMID:12579336
Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy., PMID:15102688
Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma., PMID:15154620
The Wilson disease protein ATP7B resides in the late endosomes with Rab7 and the Niemann-Pick C1 protein., PMID:15681833
Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a prognostic factor in human endometrial carcinoma., PMID:15790435
Menkes Copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains., PMID:16081413
Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells., PMID:16227410
Hepatocyte transplantation in the Long Evans Cinnamon rat model of Wilson's disease., PMID:16700326
[Hereditary hemochromatosis, alpha-1-antitrypsin deficiency and Wilson's disease. Pathogenesis, clinical findings and pathways to diagnosis]., PMID:18210110
ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile., PMID:18395099
Could ATP7B export Cu(I) at the tight junctions and the apical membrane?, PMID:18395105
Localization of the Wilson disease protein in murine intestine., PMID:18673401
Differential intracellular localisation of the Menkes and Wilson copper transporting ATPases in the third trimester human placenta., PMID:21115196
Cisplatin ototoxicity in rat cochlear organotypic cultures., PMID:21854840
Miscellaneous non-inflammatory musculoskeletal conditions. Musculoskeletal conditions associated with Wilson's disease., PMID:22142743
Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) in preclinical models of cancer., PMID:23699667
Interaction between the anticancer drug Cisplatin and the copper chaperone Atox1 in human melanoma cells., PMID:23988033
Wilson disease protein ATP7B utilizes lysosomal exocytosis to maintain copper homeostasis., PMID:24909901
Interactions between metal-binding domains modulate intracellular targeting of Cu(I)-ATPase ATP7B, as revealed by nanobody binding., PMID:25253690
D-penicillamine-induced ANA (+) ANCA (+) vasculitis in pediatric patients with Wilson's disease., PMID:26784915
A 6-year-old boy with Wilson disease-A diagnostic dilemma., PMID:28435998
Hepatocellular Carcinoma: An Unusual Complication of Longstanding Wilson Disease., PMID:28663680
Rapid Multiplexed Proteomic Screening for Primary Immunodeficiency Disorders From Dried Blood Spots., PMID:30564228
p.P1379S, a benign variant with reduced ATP7B protein level in Wilson Disease., PMID:32685348
Nanobodies against the metal binding domains of ATP7B as tools to study copper transport in the cell., PMID:33094790
eGFP as an All-in-One Tag for Purification of Membrane Proteins., PMID:37093475
Identification of 6 cuproptosis-related genes for active ulcerative colitis with both diagnostic and therapeutic values., PMID:37904461
A rare concomitance of Wilson's disease and systemic lupus erythematosus in a teenage girl: a case report and literature review., PMID:38259603
Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy., PMID:38799628
Wilson's Disease-Crossroads of Genetics, Inflammation and Immunity/Autoimmunity: Clinical and Molecular Issues., PMID:39201720
Inhalable nanoparticles with enhanced cuproptosis and cGAS-STING activation for synergistic lung metastasis immunotherapy., PMID:39220876
Some Properties of the C. elegans Multicopper Oxidase F21D5.3, an Ortholog of Human Ceruloplasmin., PMID:40429919
For research use only. Not for human or drug use.
