Catalog No.
YHB39601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro276
Predicted molecular weight
34.35 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O76038
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SECRET, Secretagogin, SCGN
Note
For research use only.
Veiled Potential of Secretagogin in Diabetes: Correlation or Coincidence?, PMID:30772140
Secretagogin Immunoreactivity Reveals Lugaro Cells in the Pigeon Cerebellum., PMID:30904983
Ferret brain possesses young interneuron collections equivalent to human postnatal migratory streams., PMID:31050805
A Pilot Study on Anti-Obesity Mechanisms of Kappaphycus Alvarezii: The Role of Native κ-Carrageenan and the Leftover Sans-Carrageenan Fraction., PMID:31117266
A microRNA‑24‑to‑secretagogin regulatory pathway mediates cholesterol‑induced inhibition of insulin secretion., PMID:31173188
Differential expression of secretagogin immunostaining in the hippocampal formation and the entorhinal and perirhinal cortices of humans, rats, and mice., PMID:31512254
Plasma Secretagogin is Increased in Individuals with Glucose Dysregulation., PMID:31546273
Secretagogin Binding Prevents α-Synuclein Fibrillation., PMID:31617346
SCGN deficiency results in colitis susceptibility., PMID:31663849
Secretagogin Regulates Insulin Signaling by Direct Insulin Binding., PMID:31734536
Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants., PMID:31796600
The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1., PMID:31918914
Structural and mechanistic insights into secretagogin-mediated exocytosis., PMID:32156735
Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A., PMID:32194720
Secretagogin is Related to Insulin Secretion but Unrelated to Gestational Diabetes Mellitus Status in Pregnancy., PMID:32708966
Clinical Routine Application of the Second-generation Neuroendocrine Markers ISL1, INSM1, and Secretagogin in Neuroendocrine Neoplasia: Staining Outcomes and Potential Clues for Determining Tumor Origin., PMID:32813226
Multiple Origins of Secretagogin Expressing Cortical GABAergic Neuron Precursors in the Early Human Fetal Telencephalon., PMID:32982702
SCGN-regulated Stage-wise SNARE Assembly: Novel Insight into Synaptic Exocytosis., PMID:33025412
Expression and clinical significance of a new neuroendocrine marker secretagogin in cervical neuroendocrine carcinoma., PMID:33060116
A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis., PMID:33289795
Secretagogin expression in the mouse olfactory bulb under sensory impairments., PMID:33299042
Secretagogin marks amygdaloid PKCδ interneurons and modulates NMDA receptor availability., PMID:33558223
Secretagogin Mediates the Regulatory Effect of Electroacupuncture on Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Surgical Trauma., PMID:33628224
Rabies virus infection is associated with alterations in the expression of parvalbumin and secretagogin in mice brain., PMID:33783673
Eggshell decalcification and skeletal mineralization during chicken embryonic development: defining candidate genes in the chorioallantoic membrane., PMID:34959155
Extracellular secretagogin is internalized into the cells through endocytosis., PMID:34967502
The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression., PMID:35034536
Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database., PMID:35114976
Secretagogin in the brain and pituitary of the catfish, Clarias batrachus: Molecular characterization and regulation by insulin., PMID:35322425
Utility of secretagogin as a marker for the diagnosis of lung neuroendocrine carcinoma., PMID:35357570
Secretagogin is a Ca2+-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies., PMID:35870554
Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes., PMID:35876276
Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids., PMID:35896708
The Cytoskeletal Transport Protein, Secretagogin, Is Essential for Diurnal Glucagon-like Peptide-1 Secretion in Mice., PMID:36036556
SCGN deficiency is a risk factor for autism spectrum disorder., PMID:36588101
ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells., PMID:36789686
16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin., PMID:37354460
Secretagogin regulates asynchronous and spontaneous glutamate release in hippocampal neurons through interaction with Doc2α., PMID:39872889
SCGN and STAT3 expressions are associated with the prognosis of ccRCC., PMID:37977033
Secretagogin as a marker to distinguish between different neuron types in human frontal and temporal cortex., PMID:38020216
A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals., PMID:38150807
Comprehensive multi-omics analysis of resectable locally advanced gastric cancer: Assessing response to neoadjuvant camrelizumab and chemotherapy in a single-center, open-label, single-arm phase II trial., PMID:38685486
Dynamic changes of SCGN expression imply different phases of clear cell renal cell carcinoma progression., PMID:38831128
The downregulation of SCGN induced by lipotoxicity promotes NLRP3-mediated β-cell pyroptosis., PMID:39068218
SCGN recruits macrophages by regulating chemokine secretion in clear cell renal cell carcinoma., PMID:39664565
CXCL10, SCGN, and H2BC5 as Potential Key Genes Regulated by HCV Infection., PMID:39766770
Integrative machine learning frameworks to uncover specific protein signature in neuroendocrine cervical carcinoma., PMID:39794740
Secretagogin Is Highly Expressed in Enteroendocrine K Cells and Plays a Critical Role in Nutrient-Induced GIP Secretion., PMID:40012909
Neuronal activity modulates the expression of secretagogin, a Ca2+ sensor protein, during mammalian forebrain development., PMID:40165367
Integrating machine learning and genetic evidence to uncover novel gene biomarkers for colorectal cancer diagnosis., PMID:40327251
For research use only. Not for human or drug use.
