Catalog No.
FHF14614
Species reactivity
Human
Host species
Human
Isotype
IgG4, kappa
Clonality
Monoclonal
Conjugation
PerCP
Applications
FCM
Target
IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
P55899
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
SAA0135
Note
For research use only.
Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves., PMID:12514749
Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves., PMID:15014972
Transport of IgG across the blood-luminal barrier of the male reproductive tract of the rat and the effect of estradiol administration on reabsorption of fluid and IgG by the epididymal ducts., PMID:15888731
Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes., PMID:16527253
Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum., PMID:19937499
Neonatal Fc receptor: from immunity to therapeutics., PMID:20886282
Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis., PMID:20930418
Colostrogenesis: candidate genes for IgG1 transcytosis mechanisms in primary bovine mammary epithelial cells., PMID:23279563
Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor., PMID:23286945
Influence of FCGRT gene polymorphisms on pharmacokinetics of therapeutic antibodies., PMID:23751752
Humanized FcRn mouse models for evaluating pharmacokinetics of human IgG antibodies., PMID:23867339
NFκB induces overexpression of bovine FcRn: a novel mechanism that further contributes to the enhanced immune response in genetically modified animals carrying extra copies of FcRn., PMID:24492342
Polymorphisms of neonatal Fc receptor in cynomolgus and rhesus macaques., PMID:24806819
Analysis of Fcgrt gene polymorphism in indigenous Chinese sheep and its association with colostrum IgG concentration., PMID:25867392
Claudin-4 undergoes age-dependent change in cellular localization on pig jejunal villous epithelial cells, independent of bacterial colonization., PMID:25948883
Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103+ Dendritic Cells Confers Transient Susceptibility to Tuberculosis., PMID:27481246
Bevacizumab Pharmacokinetics Influence Overall and Progression-Free Survival in Metastatic Colorectal Cancer Patients., PMID:27312193
Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer., PMID:28450240
Functional polymorphisms in rhesus macaque FCGRT and β2-m., PMID:28785825
Brain antibodies in the cortex and blood of people with schizophrenia and controls., PMID:28786974
Regulation of the Human Fc-Neonatal Receptor alpha-Chain Gene FCGRT by MicroRNA-3181., PMID:29302759
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex., PMID:29306331
Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium., PMID:31209240
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice., PMID:33025844
Genetic biomarkers for intravenous immunoglobulin response in chronic inflammatory demyelinating polyradiculoneuropathy., PMID:33460483
The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors., PMID:33717213
Animal models for SARS-Cov2/Covid19 research-A commentary., PMID:33812856
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21)., PMID:34040082
Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans., PMID:34514376
Detection of nucleotide variants in FCGRT (Fc fragment of IgG, receptor, transporter, alpha) gene and their influence on colostral IgG concentration in Indian water buffalo (Bubalus bubalis)., PMID:35152368
Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids., PMID:35579465
Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia., PMID:35841099
Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant HLADQA1*05G>A Genotype., PMID:36112504
Allele mining in gene encoding fc fragment of IgG receptor, transporter, alpha (FCGRT) and association of nucleotide variants with passive transfer of immunity in neonatal buffalo calves., PMID:36757548
Decoupling FcRn and tumor contributions to elevated immune checkpoint inhibitor clearance in cancer cachexia., PMID:38145833
Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy., PMID:38205888
Identifying the immunoglobulin G transporter in equine tissues: A look at the neonatal Fc receptor., PMID:38879095
Rhesus Macaques: VNTR Polymorphism of the FCGRT Gene., PMID:39134810
Population Pharmacokinetic Model of Intravenous Immunoglobulin in Patients Treated for Various Immune System Disorders., PMID:39366801
A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunity., PMID:40020261
Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway., PMID:40124052
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
For research use only. Not for human or drug use.
