The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas., PMID:32281488
ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi AS., PMID:32348365
CD4+ T Cells of Myasthenia Gravis Patients Are Characterized by Increased IL-21, IL-4, and IL-17A Productions and Higher Presence of PD-1 and ICOS., PMID:32508812
Can Molecular Imaging Measure T-cell Activation?, PMID:32669349
Decrease in immune function and the role of mitogen-activated protein kinase (MAPK) overactivation in apoptosis during T lymphocytes activation induced by zearalenone, deoxynivalenol, and their combinations., PMID:32679628
Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection., PMID:32873255
Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models., PMID:32970735
ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases., PMID:32983168
An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression., PMID:32999002
Correlations of the expression of γδ T cells and their co-stimulatory molecules TIGIT, PD-1, ICOS and BTLA with PR and PIBF in the peripheral blood and decidual tissues of women with unexplained recurrent spontaneous abortion., PMID:33017473
A Patient with Novel ICOS Mutation Presented with Progressive Loss of B Cells., PMID:33040278
Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET., PMID:33087332
ICOS is widely expressed in cutaneous T-cell lymphoma, and its targeting promotes potent killing of malignant cells., PMID:33095875
Development of a 43 color panel for the characterization of conventional and unconventional T-cell subsets, B cells, NK cells, monocytes, dendritic cells, and innate lymphoid cells using spectral flow cytometry., PMID:33336868
First-in-human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN-101, a dual CD28/ICOS antagonist, in healthy adult subjects., PMID:33503289
Zearalenone and deoxynivalenol inhibited IL-4 receptor-mediated Th2 cell differentiation and aggravated bacterial infection in mice., PMID:33556388
Increased circulating PD-1hiCXCR5- peripheral helper T cells are associated with disease severity of active ulcerative colitis patients., PMID:33675861
Implication of TIGIT+ human memory B cells in immune regulation., PMID:33750787
Treatment of solid tumors using bispecific anti-PDL-1/ICOS antibody., PMID:33829869
Impact of HIV-1 Infection and Antigen Class on T Follicular Helper Cell Responses to Pneumococcal Polysaccharide-Protein Conjugate Vaccine-13., PMID:33931485
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation., PMID:34471108
Characterising the Phenotypic Diversity of Antigen-Specific Memory B Cells Before and After Vaccination., PMID:34650561
Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination., PMID:34795301
Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models., PMID:34986869
TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells., PMID:35149531
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection., PMID:35222430
First-in-Human Phase I/II ICONIC Trial of the ICOS Agonist Vopratelimab Alone and with Nivolumab: ICOS-High CD4 T-Cell Populations and Predictors of Response., PMID:35511938
The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation., PMID:35733922
Agonizing over the Stimulatory Immune Checkpoint ICOS., PMID:35792807
Fluorophore-Conjugated Anti-ICOS Antibody Enables Precise Prediction of Therapeutic Response of the STING Agonist in Colorectal Cancer via NIRF Imaging., PMID:36018674
MiR-29a-3p negatively regulates circulating Tfh memory cells in patients with Graves' disease by targeting ICOS., PMID:36322282
Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies., PMID:36450783
Targeting the Inducible T-cell Costimulator (ICOS) in Patients with Relapsed/Refractory T-follicular Helper Phenotype Peripheral T-cell and Angioimmunoblastic T-cell Lymphoma., PMID:36826995
Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101)., PMID:36862144
Tumor-infiltrating mast cells stimulate ICOS+ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression., PMID:37086778
Interleukin-21 promotes Type-1 activation and cytotoxicity of CD56dimCD16bright natural killer cells during kidney allograft antibody-mediated rejection showing a new link between adaptive and innate humoral allo-immunity., PMID:37220805
Granulocyte-Macrophage Colony-Stimulating Factor Influence on Soluble and Membrane-Bound ICOS in Combination with Immune Checkpoint Blockade., PMID:37262321
Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation., PMID:37270182
ICOS gene polymorphisms in systemic lupus erythematosus: A case-control study., PMID:37338463
Discovery of ICOS-Targeted Small Molecules Using Pharmacophore-Based Screening., PMID:37845178
The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5-ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma., PMID:38424520
Synovial inducible costimulator is correlated with severity in knee osteoarthritis., PMID:38441341
Inducing expression of ICOS-L by oncolytic adenovirus to enhance tumor-specific bi-specific antibody efficacy., PMID:38454393
ICOS agonist vopratelimab modulates follicular helper T cells and improves B cell function in common variable immunodeficiency., PMID:38621471
Investigation of activation-induced markers (AIM) in porcine T cells by flow cytometry., PMID:38868498
Circular RNA CircZNF644 Facilitates Circulating Follicular Helper T Cells Response in Patients with Graves' Disease., PMID:38966668
In vitro modulation of T cells in myasthenia gravis by low-dose IL-2., PMID:39285833
Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment., PMID:39378431
Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model., PMID:39905410
For research use only. Not for human or drug use.
