Catalog No.
FHJ17813
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
APC
Applications
FCM
Target
Klotho beta-like protein, KLB, Beta-klotho, BetaKlotho, BKL
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
Q86Z14
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
SAA0157
Note
For research use only.
Nanobiopolymer for direct targeting and inhibition of EGFR expression in triple negative breast cancer., PMID:22355336
Safety and immunogenicity of a recombinant live attenuated tetravalent dengue vaccine (DENVax) in flavivirus-naive healthy adults in Colombia: a randomised, placebo-controlled, phase 1 study., PMID:25087476
Fibroblast growth factor 21 protects against high glucose induced cellular damage and dysfunction of endothelial nitric-oxide synthase in endothelial cells., PMID:25170746
Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient obese mice., PMID:25790234
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex., PMID:26288846
An efficient route to bispecific antibody production using single-reactor mammalian co-culture., PMID:27680183
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys., PMID:28324011
Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies., PMID:28363871
FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases., PMID:28525362
Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening., PMID:28985411
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia., PMID:28988823
FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes., PMID:29107292
A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity., PMID:29483191
Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice., PMID:29594879
A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing., PMID:29660397
Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions., PMID:30068552
Macrophages express βKlotho in skin lesions of psoriatic patients and the skin of imiquimod-treated mice., PMID:30302794
Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy., PMID:31462642
The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange., PMID:31581521
Increased Expression of FGF-21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice., PMID:31800971
Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Trial: protocol for a randomised, double-blind,placebo-controlled, treatment trial., PMID:32034019
Single- and Multi-Arm Gadolinium MRI Contrast Agents for Targeted Imaging of Glioblastoma., PMID:32431501
Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans., PMID:33139537
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice., PMID:33446655
Results of a Phase 2b Trial With GB001, a Prostaglandin D2 Receptor 2 Antagonist, in Moderate to Severe Eosinophilic Asthma., PMID:35248549
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses., PMID:35263569
A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors., PMID:35655320
Selective Pharmaceutical Inhibition of PARP14 Mitigates Allergen-Induced IgE and Mucus Overproduction in a Mouse Model of Pulmonary Allergic Response., PMID:35817532
SARS-CoV-2 Convalescent Sera Binding and Neutralizing Antibody Concentrations Compared with COVID-19 Vaccine Efficacy Estimates against Symptomatic Infection., PMID:35856710
Evaluation of the Delivery of a Live Attenuated Porcine Reproductive and Respiratory Syndrome Virus as a Unit Solid Dose Injectable Vaccine., PMID:36366345
Precision cut intestinal slices, a novel model of acute food allergic reactions., PMID:36377289
The Matrix-M™ adjuvant: A critical component of vaccines for the 21st century., PMID:37113023
Algorithm for optimized mRNA design improves stability and immunogenicity., PMID:37130545
Allergenicity evaluation of quinoa proteins - A study in Brown Norway rats., PMID:37863384
Simulation-based evaluation of personalized dosing approaches for anti-FGFR/KLB bispecific antibody fazpilodemab., PMID:38343040
Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells., PMID:38418879
Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow's milk allergy., PMID:38448113
Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis., PMID:39226764
Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice., PMID:39463193
Fibroblast growth factor 21 alleviated atopic march by inhibiting the differentiation of type 2 helper T cells., PMID:39798471
Evaluation of a novel malaria anti-sporozoite vaccine candidate, R21 in Matrix-M adjuvant, in the UK and Burkina Faso: two phase 1, first-in-human trials., PMID:39805302
For research use only. Not for human or drug use.
