Anti-Human GFRAL Antibody (25M22), APC

Catalog No.

FHH55913

Species reactivity

Human

Host species

Mouse

Isotype

IgG1, kappa

Clonality

Monoclonal

Conjugation

APC

Target

C6orf144, GDNF family receptor alpha-like, GFRAL

Concentration

0.5 mg/ml

Endotoxin level

Please contact with the lab for this information.

Accession

Q6UXV0

Applications

FCM

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Stability and Storage

Store at 4°C for 12 months. Protect from light. Do not freeze.

Clone ID

25M22

Note

For research use only.

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL., PMID:28846098

GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS., PMID:31152154

GDF15 mediates the effects of metformin on body weight and energy balance., PMID:31875646

Antibody-mediated inhibition of GDF15-GFRAL activity reverses cancer cachexia in mice., PMID:32661391

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling., PMID:32723474

An Antibody Attack against Body Wasting in Cancer., PMID:32877689

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation., PMID:33903632

Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15., PMID:34187898

Camptothecin effectively treats obesity in mice through GDF15 induction., PMID:35202387

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells., PMID:35626166

The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice., PMID:36427806

Area postrema neurons mediate interleukin-6 function in cancer-associated cachexia., PMID:36711916

GDNF family receptor alpha-like antagonist antibody alleviates chemotherapy-induced cachexia in melanoma-bearing mice., PMID:37017344

GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion., PMID:37224335

Area postrema neurons mediate interleukin-6 function in cancer cachexia., PMID:38824130

Neutralizing antibody against GDF15 for treatment of cancer-associated cachexia., PMID:39172988

GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models., PMID:39400041

Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker., PMID:39781722

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Anti-Human GFRAL Antibody (25M22), APC.pdf