Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis., PMID:22422496
OX40 ligand and OX40 are increased in atopic dermatitis lesions but do not correlate with clinical severity., PMID:22646697
An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas., PMID:22781551
Identification and characterization of an agonistic aptamer against the T cell costimulatory receptor, OX40., PMID:23113766
Blockade of OX40/OX40 ligand to decrease cytokine messenger RNA expression in acute renal allograft rejection in vitro., PMID:23953582
Natural OX40L expressed on human T cell leukemia virus type-I-immortalized T cell lines interferes with infection of activated peripheral blood mononuclear cells by CCR5-utilizing human immunodeficiency virus., PMID:24238037
OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis., PMID:24469824
When assay format matters: a case study on the evaluation of three assay formats to support a clinical pharmacokinetic study., PMID:24752719
Soluble OX40L is associated with presence of autoantibodies in early rheumatoid arthritis., PMID:25359291
Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor., PMID:25897665
Regulation of Th1/Th2 balance through OX40/OX40L signalling by glycyrrhizic acid in a murine model of asthma., PMID:26467500
OX40L blockade protects against inflammation-driven fibrosis., PMID:27298374
Inflammatory disease: T cell-targeted antibody reverses fibrosis., PMID:27444224
Second- and third-generation drugs for immuno-oncology treatment-The more the better?, PMID:28335888
The Immune Checkpoint Modulator OX40 and Its Ligand OX40L in NK-Cell Immunosurveillance and Acute Myeloid Leukemia., PMID:29321210
Separation of plasma-derived exosomes into CD3(+) and CD3(-) fractions allows for association of immune cell and tumour cell markers with disease activity in HNSCC patients., PMID:29431869
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein., PMID:29545330
Transcription profiling of peripheral B cells in antibody-positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature., PMID:29655283
Preparation, characterization and application of anti-human OX40 ligand (OX40L) monoclonal antibodies and establishment of a sandwich ELISA for autoimmune diseases detection., PMID:30562687
Kawasaki disease OX40-OX40L axis acts as an upstream regulator of NFAT signaling pathway., PMID:30723312
Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21., PMID:31105701
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members., PMID:31156033
Statins can suppress DC-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression., PMID:31269241
A bispecific IgG format containing four independent antigen binding sites., PMID:32005942
Tumor Infiltration by OX40+ Cells Enhances the Prognostic Significance of CD16+ Cell Infiltration in Colorectal Cancer., PMID:32107932
The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis., PMID:32176307
OX40 and LAG3 are associated with better prognosis in advanced gastric cancer patients treated with anti-programmed death-1 antibody., PMID:32203221
Safety, tolerability and efficacy of repeated intravenous infusions of KHK4083, a fully human anti-OX40 monoclonal antibody, in Japanese patients with moderate to severe atopic dermatitis., PMID:32651105
Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy., PMID:32707816
Induction of Antigen-Independent Proliferation of Regulatory T-Cells by TNF Superfamily Ligands OX40L and GITRL., PMID:33185867
Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD/Scid IL2Rγnull mice reconstituted with human peripheral blood mononuclear cells., PMID:33293281
Human peripheral basophils extended phenotype shows a high expression of CD244 immuno-regulatory receptor., PMID:33493550
A Phase 1 Study of KHK4083: A Single-Blind, Randomized, Placebo-Controlled Single-Ascending-Dose Study in Healthy Adults and an Open-Label Multiple-Dose Study in Patients With Ulcerative Colitis., PMID:33512065
Blinatumomab-induced T cell activation at single cell transcriptome resolution., PMID:33648458
Roles of OX40 and OX40 Ligand in Mycosis Fungoides and Sézary Syndrome., PMID:34830466
PCSK9 Suppresses M2-Like Tumor-Associated Macrophage Polarization by Regulating the Secretion of OX40L from Hepatocellular Carcinoma Cells., PMID:35078374
OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005., PMID:35092305
In Situ Reprogramming of Tumors for Activating the OX40/OX40 Ligand Checkpoint Pathway and Boosting Antitumor Immunity., PMID:35653749
Toll-like receptor 7 agonist, GS-986, is an immune-stimulant inducing follicular helper T cells and expanding HBs antigen-specific B cells in vitro., PMID:37029645
Analysis of a new therapeutic target and construction of a prognostic model for breast cancer based on ferroptosis genes., PMID:37643511
Comparative evaluation of antitumor effects of TNF superfamily costimulatory ligands delivered by mesenchymal stem cells., PMID:37995568
OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520
OX40/OX40 ligand and its role in precision immune oncology., PMID:38526805
An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026
Regulation of the Function of T Follicular Helper Cells and B Cells in Type 1 Diabetes Mellitus by the OX40/OX40L Axis., PMID:38625053
The Role of OX40-OX40L Axis in the Pathogenesis of Atopic Dermatitis., PMID:38700255
NK Cell Degranulation Triggered by Rituximab Identifies Potential Markers of Subpopulations with Enhanced Cytotoxicity toward Malignant B Cells., PMID:39201666
Making the effect visible - OX40 targeting nanobodies for in vivo imaging of activated T cells., PMID:39474429
Comparison of CD30L and OX40L Reveals CD30L as a Promising Therapeutic Target in Atopic Dermatitis., PMID:39589186
Activation of immune checkpoint OX40 inhibits HBV replication in a mouse model., PMID:39923582
For research use only. Not for human or drug use.
