Catalog No.
YHA16501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser80-Pro316
Predicted molecular weight
29.06 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00587
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, MFNG, Beta-1,3-N-acetylglucosaminyltransferase manic fringe
Note
For research use only.
Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12., PMID:9878264
Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes., PMID:10341080
Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity., PMID:10523836
Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH)., PMID:10640833
Demarcation of early mammalian cortical development by differential expression of fringe genes., PMID:10675782
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2., PMID:10934472
Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation., PMID:11346656
Expression of Notch pathway components in fetal and adult mouse small intestine., PMID:12617809
Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development., PMID:12971992
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation., PMID:15280477
Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe., PMID:15376327
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1., PMID:15574878
Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe., PMID:16880554
The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3., PMID:16920096
Structural insights into the Notch-modifying glycosyltransferase Fringe., PMID:16964258
Engineering of a mammalian O-glycosylation pathway in the yeast Saccharomyces cerevisiae: production of O-fucosylated epidermal growth factor domains., PMID:18252777
Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype., PMID:19026002
Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches., PMID:19217325
MFng is dispensable for mouse pancreas development and function., PMID:19223466
Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain., PMID:19479951
Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas., PMID:19501159
Regulation of Notch signaling during T- and B-cell development by O-fucose glycans., PMID:19594638
Identification and validation of genes involved in gastric tumorigenesis., PMID:21092330
The N-acetyl-binding pocket of N-acetylglucosaminyltransferases also accommodates a sugar analog with a chemical handle at C2., PMID:21868414
Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling., PMID:22081605
Fringe controls naïve CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models., PMID:23071776
Biosynthesis of the anti-infective marformycins featuring pre-NRPS assembly line N-formylation and O-methylation and post-assembly line C-hydroxylation chemistries., PMID:25746634
Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction., PMID:25808869
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development., PMID:26608918
Sequential Notch activation regulates ventricular chamber development., PMID:26641715
Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates., PMID:27966429
Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands., PMID:28089369
Enhanced osteogenic differentiation of rat bone marrow mesenchymal stem cells on titanium substrates by inhibiting Notch3., PMID:28366784
Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis., PMID:29629872
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells., PMID:30065304
Identification of novel LFNG mutations in spondylocostal dysostosis., PMID:30531807
Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade., PMID:31789590
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2., PMID:32820046
Nuclear and stromal expression of Manic fringe in renal cell carcinoma., PMID:34371013
Modulation of the NOTCH1 Pathway by LUNATIC FRINGE Is Dominant over That of MANIC or RADICAL FRINGE., PMID:34641486
Downregulation of Manic fringe impedes angiogenesis and cell migration of renal carcinoma., PMID:35157839
Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells., PMID:35623385
Fringe family genes and their modulation of Notch signaling in cancer., PMID:35660646
A novel glycosylation-related gene signature predicts survival in patients with lung adenocarcinoma., PMID:36575396
Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis., PMID:37329502
MFNG is an independent prognostic marker for osteosarcoma., PMID:37496053
A pan-cancer analysis revealing the role of LFNG, MFNG and RFNG in tumor prognosis and microenvironment., PMID:37932706
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development., PMID:39528804
Exploring the relationship between sepsis and Golgi apparatus dysfunction: bioinformatics insights and diagnostic marker discovery., PMID:39981259
For research use only. Not for human or drug use.
