Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production. PMID: 31871532
Differential Expression Analysis Revealing CLCA1 to Be a Prognostic and Diagnostic Biomarker for Colorectal Cancer. PMID: 33251137
CLCA1 and TMEM16A: the link towards a potential cure for airway diseases. PMID: 26296094
Structural and Biophysical Analysis of the CLCA1 VWA Domain Suggests Mode of TMEM16A Engagement. PMID: 31995732
CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway. PMID: 28974231
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties. PMID: 31570526
Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages. PMID: 29610986
Secretory diarrhoea: mechanisms and emerging therapies. PMID: 26122478
Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells. PMID: 25781344
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. PMID: 29885864
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A. PMID: 34066250
Role of ion channels in gastrointestinal cancer. PMID: 31636470
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. PMID: 24942678
Role of goblet cell protein CLCA1 in murine DSS colitis. PMID: 26855614
[AIRWAY EPITHELIAL CELL DIFFERENTIATION AND HYPERSECRETION -THE ROLE OF IL-13, CLCA1 AND TMEM16A]. PMID: 29129885
Intracellular Ion Channels in Pancreas Cancer. PMID: 31834994
Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. PMID: 23112050
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PMID: 26162072
Corrigendum: Differential Expression Analysis Revealing CLCA1 to Be a Prognostic and Diagnostic Biomarker for Colorectal Cancer. PMID: 33392101
Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1). PMID: 28420732
Differential association of MUC5AC and CLCA1 expression in small cartilaginous airways of RAO-affected and control horses. PMID: 20095232
Is rabbit CLCA1 related to the basolateral Ca2+ -dependent Cl- channel of gastric parietal cells? PMID: 11282004
Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents. PMID: 19307298
CLCA1 gene polymorphisms in chronic obstructive pulmonary disease. PMID: 14985398
Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice. PMID: 30267575
Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis. PMID: 27803115
TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells. PMID: 33026825
Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors. PMID: 18616988
The Emerging Role of Calcium-activated Chloride Channel Regulator 1 in Cancer. PMID: 30952704
Bioinformatics Analysis and Identification of Underlying Biomarkers Potentially Linking Allergic Rhinitis and Asthma. PMID: 32460303
Expression of the Ca2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. PMID: 11445004
HO-1 inhibits IL-13-induced goblet cell hyperplasia associated with CLCA1 suppression in normal human bronchial epithelial cells. PMID: 26507166
Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis. PMID: 20179644
Comparative Proteomics of Ovarian Cancer Aggregate Formation Reveals an Increased Expression of Calcium-activated Chloride Channel Regulator 1 (CLCA1). PMID: 26004777
Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins. PMID: 9828122
The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1. PMID: 11994272
Increased human Ca²⁺-activated Cl⁻ channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients. PMID: 22731784
Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer. PMID: 25603912
Increased mucus accumulation in horses chronically affected with recurrent airway obstruction is not associated with up-regulation of CLCA1, EGFR, MUC5AC, Bcl-2, IL-13 and INF-gamma expression. PMID: 18597857
Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma. PMID: 30419838
High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy. PMID: 30123054
Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells. PMID: 11850505
Prognostic value of chloride channel accessory mRNA expression in colon cancer. PMID: 31404307
Defining lung adenocarcinoma subtypes with glucocorticoid-related genes and constructing a prognostic index for immunotherapy guidance., PMID:40400930
Clca1 deficiency exacerbates colitis susceptibility via impairment of mucus barrier integrity and gut microbiota homeostasis., PMID:40300372
Comprehensive bioinformatics analysis was used to identify and verify differentially expressed genes in targeted therapy of colon cancer., PMID:40295509
Deciphering the Metabolic Impact and Clinical Relevance of N-Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling., PMID:40285620
Hypobaric hypoxia exposure impairs colonic goblet cell subpopulation via the HIF-1α signaling pathway., PMID:40132123
The CLCA1/TMEM16A/Cl- current axis associates with H2S deficiency in diabetic kidney injury., PMID:39782685
CLCA1 and BPIFB1 are potential novel biomarkers for asthma: an iTRAQ analysis., PMID:39552876
Personalized oncology in pheochromocytomas and paragangliomas: integrating genetic analysis with machine learning., PMID:39420072
Identification and validation of metastasis-related gene ZG16 in the prognosis and progression in colorectal cancer., PMID:39114307
CLCA1, a tumour suppressor in hepatocellular carcinoma., PMID:39097422
Long-Term PM2.5 Exposure and Upregulation of CLCA1 Expression in Nasal Epithelium from Youth with Asthma., PMID:38986136
Modulation of TMEM16B channel activity by the calcium-activated chloride channel regulator 4 (CLCA4) in human cells., PMID:38825009
Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer: Integrating Bioinformatics Analysis with Experimental Confirmation., PMID:38809379
CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome., PMID:38597420
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis., PMID:38593125
CLCA1 1 in cancer: A tumor suppressor or oncogene?, PMID:38369408
Explore Key Genes and Mechanisms Involved in Colon Cancer Progression Based on Bioinformatics Analysis., PMID:38294732
Weighted gene co-expression network analysis for hub genes in colorectal cancer., PMID:38150140
Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection., PMID:37869014
Identification and validation of key genes associated with pathogenesis and prognosis of gastric cancer., PMID:37868053
An Analysis of the Gene Expression Associated with Lymph Node Metastasis in Colorectal Cancer., PMID:37719786
Expression Profiling along the Murine Intestine: Different Mucosal Protection Systems and Alterations in Tff1-Deficient Animals., PMID:37628863
Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons., PMID:37607995
Identification of Proteins Involved in Cell Membrane Permeabilization by Nanosecond Electric Pulses (nsEP)., PMID:37298142
Colonic mucin-2 attenuates acute necrotizing pancreatitis in rats by modulating intestinal homeostasis., PMID:37249555
Bioinformatic Analysis of Key Regulatory Genes in Adult Asthma and Prediction of Potential Drug Candidates., PMID:37241840
Tumor suppressor CLCA1 inhibits angiogenesis via TGFB1/SMAD/VEGF cascade and sensitizes hepatocellular carcinoma cells to Sorafenib., PMID:37230858
Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix., PMID:36907435
G-quadruplex-enhanced circular single-stranded DNA (G4-CSSD) adsorption of miRNA to inhibit colon cancer progression., PMID:36855796
Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways., PMID:36768559
Panomics reveals patient individuality as the major driver of colorectal cancer progression., PMID:36691026
Solithromycin inhibits IL-13-induced goblet cell hyperplasia and MUC5AC, CLCA1, and ANO1 in human bronchial epithelial cells., PMID:36684665
Bronchial epithelial cell transcriptome shows endotype heterogeneity of asthma in patients with NSAID-exacerbated respiratory disease., PMID:36395984
Genomic, biochemical and expressional properties reveal strong conservation of the CLCA2 gene in birds and mammals., PMID:36389428
Pharmacological OGG1 inhibition decreases murine allergic airway inflammation., PMID:36324676
CLCA1 mediates the regulatory effect of IL-13 on pediatric asthma., PMID:36313877
Constructing a molecular subtype model of colon cancer using machine learning., PMID:36188575
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity., PMID:36066606
Elevated CXCL14 in Induced Sputum Was Associated with Eosinophilic Inflammation and Airway Obstruction in Patients with Asthma., PMID:36063806
Identification of Hub Genes in Colorectal Adenocarcinoma by Integrated Bioinformatics., PMID:35693937
Proteomics analyses of Xiaopi granules in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric epithelial dysplasia rat model using LC-MS., PMID:35599573
Identifying key genes and functionally enriched pathways in Th2-high asthma by weighted gene co-expression network analysis., PMID:35550122
Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model., PMID:35438004
Evolutionarily conserved properties of CLCA proteins 1, 3 and 4, as revealed by phylogenetic and biochemical studies in avian homologues., PMID:35417490
Analyzing large scale gene expression data in colorectal cancer reveals important clues; CLCA1 and SELENBP1 downregulated in CRC not in normal and not in adenoma., PMID:35141024
Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity., PMID:34784295
Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels., PMID:34488544
Employing bioinformatics analysis to identify hub genes and microRNAs involved in colorectal cancer., PMID:34390411
Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice., PMID:34354243
Landscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing., PMID:34158745
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