Catalog No.
YVV40501
Expression system
E. coli
Species
Chikungunya virus (CHIKV)
Protein length
Asp1004-Gln1327
Predicted molecular weight
71.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A6MH24
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Polyprotein P1234, Non-structural polyprotein
Effectiveness of 3-amino-2-thiocyanato-α, β-unsaturated carbonyl compounds against chikungunya virus., PMID:40511668
Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans., PMID:40398392
Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity., PMID:40351160
Novel peptide inhibitor for the Chikungunya virus nsP2 protease: Identification and characterization., PMID:40165933
Attenuation of Chikungunya Virus by a Single Amino Acid Substitution in the nsP1 Component of a Non-Structural Polyprotein., PMID:40007036
A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity., PMID:39981948
Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4'-Fluorouridine., PMID:39804924
Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection., PMID:39775571
Recent advances in phytocompounds as potential Chikungunya virus non-structural protein 2 protease antagonists: A systematic review., PMID:39756312
Identification of Inhibitors of Chikungunya virus nsP2 ATPase., PMID:39677726
The potential inhibitory mechanism of EGCG against the Chikungunya virus targeting non-structural protein 2 through molecular dynamics simulation., PMID:39616212
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach., PMID:39388272
Inhibitor of the non-structural protein 2 protease shows promising efficacy in mouse models of chikungunya., PMID:39236495
Cell Culture and Molecular Docking Analysis to Determine the Antiviral Activity of Folklore Medicinal Plants Against Chikungunya Virus., PMID:39234913
Computational Insights for Interactions between nsP2 and nsP3 of CHIKV and Hormones through DFT Computations and Molecular Dynamics Simulations., PMID:39137144
The evolutionary and molecular history of a chikungunya virus outbreak lineage., PMID:39058744
Halogenated Secondary Metabolites from Higher Plants: Potent Drug Candidates for Chikungunya Using in silico Approaches., PMID:38905281
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach., PMID:38562906
Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2., PMID:38483968
Drugs targeting structural and nonstructural proteins of the chikungunya virus: A review., PMID:38311132
A hidden gem Catenin-α-1 is essential for Chikungunya virus infection., PMID:37962368
Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2., PMID:37961400
Chikungunya virus perturbs the Wnt/β-catenin signaling pathway for efficient viral infection., PMID:37861335
Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti., PMID:37669371
In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease., PMID:37515189
Design, synthesis, antiviral evaluation, and In silico studies of acrylamides targeting nsP2 from Chikungunya virus., PMID:37364511
Genomic Characterization of Mosquito Isolates of Chikungunya Virus (Outbreak Strains 2022) Using Next-Generation Sequencing., PMID:37184895
Drug repurposing approach against chikungunya virus: an in vitro and in silico study., PMID:37180434
Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene Sequence., PMID:37112813
Immunological impact of cytokines on the chikungunya virus pathophysiology: A literature narrative review., PMID:37021332
The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling., PMID:36848386
Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication., PMID:36840772
DNA Damage Response Signaling Is Crucial for Effective Chikungunya Virus Replication., PMID:36377875
Inhibition of Chikungunya virus early replication by intracellular nanoantibodies targeting nsP2 Epitope Rich Region., PMID:36270543
Architecture of the chikungunya virus replication organelle., PMID:36259931
G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya Virus., PMID:36226983
Structural insights into the inhibition of the nsP2 protease from Chikungunya virus by molecular modeling approaches., PMID:36097090
Riboflavin, a Potent Neuroprotective Vitamin: Focus on Flavivirus and Alphavirus Proteases., PMID:35889050
MBZM-N-IBT, a Novel Small Molecule, Restricts Chikungunya Virus Infection by Targeting nsP2 Protease Activity In Vitro, In Vivo, and Ex Vivo., PMID:35766508
Chikungunya Virus' High Genomic Plasticity Enables Rapid Adaptation to Restrictive A549 Cells., PMID:35215875
Chikungunya virus: Molecular epidemiology of nonstructural proteins in Pakistan., PMID:34941888
Neurological infection by chikungunya and a triple Arbovirus co-infection in Mato Grosso, Central Western Brazil during 2019., PMID:34923322
Chikungunya virus non-structural protein nsP3 interacts with Aedes aegypti DEAD-box helicase RM62F., PMID:34901322
Indole alkaloids inhibit zika and chikungunya virus infection in different cell lines., PMID:34454481
Semliki Forest Virus Chimeras with Functional Replicase Modules from Related Alphaviruses Survive by Adaptive Mutations in Functionally Important Hot Spots., PMID:34319778
Novel Analogues of the Chikungunya Virus Protease Inhibitor: Molecular Design, Synthesis, and Biological Evaluation., PMID:34056242
Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein 2., PMID:33903104
Inhibition of Chikungunya Virus Infection by 4-Hydroxy-1-Methyl-3-(3-morpholinopropanoyl)quinoline-2(1H)-one (QVIR) Targeting nsP2 and E2 Proteins., PMID:33869959
1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors., PMID:33681617
Prediction of promiscuous epitopes in NSP2 of Chikungunya virus: An in-silico approach., PMID:33612772
For research use only. Not for human or drug use.
