A novel adenosine 2A receptor antagonist HZ-086 enhances the efficiency of immunotherapy and alleviates the acquired resistance to PD-L1 by restoration of T cell functions., PMID:40118325
Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells., PMID:40081940
Research progress in bifunctional small molecules for cancer immunotherapy., PMID:39919914
Autophagy and Akt-Stimulated Cellular Proliferation Synergistically Improve Antibody Production in CHO Cells., PMID:39623740
Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury., PMID:39135700
Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A2A receptor., PMID:38837964
Adenosine Increases the Immunosuppressive Capacity of Cervical Cancer Cells by Increasing PD-L1 Expression and TGF-β Production through Its Interaction with A2AR/A2BR., PMID:38543183
A phase 2 study of AZD4635 in combination with durvalumab or oleclumab in patients with metastatic castration-resistant prostate cancer., PMID:38430405
Unlocking antitumor immunity with adenosine receptor blockers., PMID:38263981
A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses., PMID:37914685
Adenosine in cancer immunotherapy: Taking off on a new plane., PMID:37913941
Palpitation in women with silicone breast implants: association with autoantibodies against autonomic nervous system., PMID:37845561
Relationship between the Gene Expression of Adenosine Kinase Isoforms and the Expression of CD39 and CD73 Ectonucleotidases in Colorectal Cancer., PMID:37538807
Inhibitors of the CD73-adenosinergic checkpoint as promising combinatory agents for conventional and advanced cancer immunotherapy., PMID:37435071
A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension., PMID:37377160
Review immune response of targeting CD39 in cancer., PMID:37287049
CD39/CD73/A2AR pathway and cancer immunotherapy., PMID:36859386
Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy., PMID:36445478
Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death., PMID:35836249
Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients., PMID:35708739
Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer., PMID:35254415
Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model., PMID:33737925
Targeted Regulation of Blood-Brain Barrier for Enhanced Therapeutic Efficiency of Hypoxia-Modifier Nanoparticles and Immune Checkpoint Blockade Antibodies for Glioblastoma., PMID:33684289
Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells., PMID:33532505
Increased expression of adenosine 2A receptors in metastatic renal cell carcinoma is associated with poorer response to anti-vascular endothelial growth factor agents and anti-PD-1/Anti-CTLA4 antibodies and shorter survival., PMID:33416945
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade., PMID:32409420
Expression of a short antibody heavy chain peptide effectively antagonizes adenosine 2A receptor in vitro and in vivo., PMID:32308059
Targeting an adenosine-mediated "don't eat me signal" augments anti-lymphoma immunity by anti-CD20 monoclonal antibody., PMID:32269319
Control of Metastases via Myeloid CD39 and NK Cell Effector Function., PMID:31992567
Detection of G Protein-Coupled Receptor Complexes in Postmortem Human Brain by Proximity Ligation Assay., PMID:31943888
Adenosine 2A Receptor Activation Contributes to Ang II-Induced Aortic Remodeling by Promoting Macrophage Retention., PMID:31786982
Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer., PMID:31732494
Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma., PMID:30941125
Pharmacological profile of adenosine A2A receptors in patients with lower extremity peripheral artery disease and associated coronary artery disease: A pilot study., PMID:30850237
Caffeine inhibits hypoxia-induced nuclear accumulation in HIF-1α and promotes neonatal neuronal survival., PMID:30822423
Tumor CD73/A2aR adenosine immunosuppressive axis and tumor-infiltrating lymphocytes in diffuse large B-cell lymphoma: correlations with clinicopathological characteristics and clinical outcome., PMID:30664812
A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats., PMID:30453021
Cervical cancer cells produce TGF-β1 through the CD73-adenosine pathway and maintain CD73 expression through the autocrine activity of TGF-β1., PMID:30301599
Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy., PMID:30293873
Adenosine A2A receptor antagonists act at the hyperoxic phase to confer protection against retinopathy., PMID:30134834
PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling., PMID:29995853
The wakefulness promoting drug Modafinil causes adenosine receptor-mediated upregulation of receptor activator of nuclear factor κB ligand in osteoblasts: Negative impact of the drug on peak bone accrual in rats., PMID:29649498
CD73-A2a adenosine receptor axis promotes innate B cell antibody responses to pneumococcal polysaccharide vaccination., PMID:29377929
Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists., PMID:29366930
The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin., PMID:29145453
Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2A Receptor to Promote the Establishment of Infection., PMID:28775724
The future of immune checkpoint cancer therapy after PD-1 and CTLA-4., PMID:28653573
Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases., PMID:28638737
A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment., PMID:28582704
Adenosine A2A receptors are up-regulated and control the activation of human alveolar macrophages., PMID:28499635
For research use only. Not for human or drug use.
