Catalog No.
DHK06703
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Target
RTN-x, Reticulon-4, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, NOGO, Nogo protein, Neurite outgrowth inhibitor, NSP, Reticulon-5, KIAA0886, RTN4, Foocen
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NQC3
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
NG-101, NG101, NG 101
Clone ID
NG-101
Intrathecal administration of Anti-Nogo-A antibody in macaque monkeys: Pharmacokinetics, tissue penetration and target interaction., PMID:39572304
Glucopeptides derived from myelin-relevant proteins and hyperglucosylated nontypeable Haemophilus influenzae bacterial adhesin cross-react with multiple sclerosis specific antibodies: A step forward in the identification of native autoantigens in multiple sclerosis., PMID:36597597
Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays., PMID:35939377
Comparative Analysis of Neurodegeneration and Axonal Dysfunction Biomarkers in the Cerebrospinal Fluid of Patients with Multiple Sclerosis., PMID:35887886
PKD2/polycystin-2 induces autophagy by forming a complex with BECN1., PMID:32543276
Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules., PMID:31469817
Axonal Guidance Signaling Pathway Is Suppressed in Human Nasal Polyps., PMID:29754498
Superman and the Swiss Continence Foundation., PMID:25891315
RTN4/Nogo is an independent prognostic marker for gastric cancer: preliminary results., PMID:25683937
Anti-Nogo-A antibody: a treatment option for neurogenic lower urinary tract dysfunction?, PMID:25430943
Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial., PMID:24841795
Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis., PMID:24667415
Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions., PMID:24292009
Intracellular Nogo-A facilitates initiation of neurite formation in mouse midbrain neurons in vitro., PMID:24157929
Long-term motor cortical map changes following unilateral lesion of the hand representation in the motor cortex in macaque monkeys showing functional recovery of hand functions., PMID:24064551
Therapeutics targeting Nogo-A hold promise for stroke restoration., PMID:23394537
From bench to beside to cure spinal cord injury: lost in translation?, PMID:23211464
Expression of nogo-a is decreased with increasing gestational age in the human fetal brain., PMID:23146900
The role of Nogo-A in axonal plasticity, regrowth and repair., PMID:22588543
Spinal cord injury: taking a detour to recovery (Commentary on Schnell et al.)., PMID:21999581
Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord., PMID:21995852
Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration., PMID:20886841
Anti-Nogo on the go: from animal models to a clinical trial., PMID:20590535
Neurites regrowth of cortical neurons by GSK3beta inhibition independently of Nogo receptor 1., PMID:20374426
A systematic review of directly applied biologic therapies for acute spinal cord injury., PMID:20082560
Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis., PMID:19433749
Fate of rubrospinal neurons after unilateral section of the cervical spinal cord in adult macaque monkeys: effects of an antibody treatment neutralizing Nogo-A., PMID:18508036
Soluble Nogo-A in CSF is not a useful biomarker for multiple sclerosis., PMID:18495952
Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists., PMID:18411262
The N-terminal domain of Nogo-A inhibits cell adhesion and axonal outgrowth by an integrin-specific mechanism., PMID:18234903
Nogo-A inhibition induces recovery from neglect in rats., PMID:17963852
Targeting the Nogo-A signalling pathway to promote recovery following acute CNS injury., PMID:17692015
Epitope mapping of the neuronal growth inhibitor Nogo-A for the Nogo receptor and the cognate monoclonal antibody IN-1 by means of the SPOT technique., PMID:17486692
Repair of the injured spinal cord. A joint approach of basic and clinical research., PMID:17429219
Localisation and expression of a myelin associated neurite inhibitor, Nogo-A and its receptor Nogo-receptor by mammalian CNS cells., PMID:17428512
Nogo-A is a reliable oligodendroglial marker in adult human and mouse CNS and in demyelinated lesions., PMID:17356385
Identification of CRMP4 as a convergent regulator of axon outgrowth inhibition., PMID:17301178
Detection of anti-Nogo receptor autoantibody in the serum of multiple sclerosis and controls., PMID:17295709
Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease., PMID:16772867
Nogo in multiple sclerosis: growing roles of a growth inhibitor., PMID:16682057
A class of membrane proteins shaping the tubular endoplasmic reticulum., PMID:16469703
Inhibition of Nogo: a key strategy to increase regeneration, plasticity and functional recovery of the lesioned central nervous system., PMID:16338758
Nogo-B is a new physiological substrate for MAPKAP-K2., PMID:16095439
Identification of a functional epitope of the Nogo receptor by a combinatorial approach using ribosome display., PMID:16061255
Regenerating corticospinal fibers in the Marmoset (Callitrix jacchus) after spinal cord lesion and treatment with the anti-Nogo-A antibody IN-1., PMID:15525289
Easing the brakes on spinal cord repair., PMID:15459707
[Nogo-A functions during the development of the central nervous system and in the adult]., PMID:15378458
Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells., PMID:15312170
Nogo and Nogo-66 receptor in human and chick: implications for development and regeneration., PMID:15305291
A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin., PMID:15297463
For research use only. Not for human or drug use.
