Catalog No.
DHH22301
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Target
Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q15858
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Duke anti-NAv1.7
Makatoxin-3, a thermostable Nav1.7 agonist from Buthus martensii Karsch (BmK) scorpion elicits non-narcotic analgesia in inflammatory pain models., PMID:35063590
Association of small-fiber polyneuropathy with three previously unassociated rare missense SCN9A variants., PMID:32719824
Nanodisc technology facilitates identification of monoclonal antibodies targeting multi-pass membrane proteins., PMID:31980674
3'-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model., PMID:31805638
Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers., PMID:31550995
Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species., PMID:31387871
Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies., PMID:29333591
Pathogenesis of abdominal pain in bowel obstruction: role of mechanical stress-induced upregulation of nerve growth factor in gut smooth muscle cells., PMID:28079757
No gain, no pain: NaV1.7 as an analgesic target., PMID:25111714
Nerve growth factor induces sensitization of nociceptors without evidence for increased intraepidermal nerve fiber density., PMID:23891896
Involvement of trigeminal ganglionic Nav 1.7 in hyperalgesia of inflamed temporomandibular joint is dependent on ERK1/2 phosphorylation of glial cells in rats., PMID:23242737
Secondary erythromelalgia successfully treated with intravenous immunoglobulin., PMID:22156790
Absence of pain with hyperhidrosis: a new syndrome where vascular afferents may mediate cutaneous sensation., PMID:19836135
Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat., PMID:18806059
Nav1.7 expression is increased in painful human dental pulp., PMID:18426592
Increased nerve fiber expression of sensory sodium channels Nav1.7, Nav1.8, And Nav1.9 in rhinitis., PMID:18197135
Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain., PMID:17950013
Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain)., PMID:17928139
Na(v)1.7 sodium channel expression in human lingual nerve neuromas., PMID:17210118
Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat., PMID:15219259
Plasticity of TTX-sensitive sodium channels PN1 and brain III in injured human nerves., PMID:11234752
For research use only. Not for human or drug use.
