Catalog No.
DHG08901
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Target
RSE, TYRO3, Tyrosine-protein kinase TIF, Tyrosine-protein kinase RSE, BYK, Tyrosine-protein kinase BYK, DTK, TIF, Tyrosine-protein kinase DTK, SKY, Tyrosine-protein kinase SKY, Tyrosine-protein kinase receptor TYRO3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q06418
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
ELB031, ELB 031, ELB-031
Clone ID
ELB031
Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl., PMID:40040711
SAFFRON-104: a phase Ib/II study of sitravatinib alone or with tislelizumab in advanced hepatocellular carcinoma and gastric cancer/gastroesophageal junction cancer., PMID:39235596
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability., PMID:38666935
A Phase 2 Study of Sitravatinib in Combination with Nivolumab in Patients with Advanced or Metastatic Urothelial Carcinoma., PMID:38105142
Correction: Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis., PMID:37653485
Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders., PMID:37545504
Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis., PMID:37537628
Soluble Tyro-3 and Axl may reflect the current activity and renal involvement in patients with microscopic polyangiitis and granulomatosis with polyangiitis., PMID:36995311
MRTX-500 Phase 2 Trial: Sitravatinib With Nivolumab in Patients With Nonsquamous NSCLC Progressing On or After Checkpoint Inhibitor Therapy or Chemotherapy., PMID:36842467
Elevated expression of TAM receptor tyrosine kinase in synovial fluid and synovial tissue of rheumatoid arthritis., PMID:35951003
Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein., PMID:35927581
The Development of AXL Inhibitors in Lung Cancer: Recent Progress and Challenges., PMID:35311091
AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew., PMID:34638349
Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study., PMID:34599023
Exploiting the efficacy of Tyro3 and folate receptors to enhance the delivery of gold nanoparticles into colorectal cancer cells in vitro., PMID:36132641
Cabozantinib: An evolving therapy for hepatocellular carcinoma., PMID:34029957
MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer., PMID:33562150
TAM receptors: A phosphatidylserine receptor family and its implications in viral infections., PMID:33234246
Anti-Tyro3 IgG Associates with Disease Activity and Reduces Efferocytosis of Macrophages in New-Onset Systemic Lupus Erythematosus., PMID:33224991
Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis., PMID:33121494
Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis., PMID:32964059
CD14+CD16- monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK., PMID:32958023
Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia., PMID:32722558
Cabozantinib in combination with atezolizumab versus sorafenib in treatment-naive advanced hepatocellular carcinoma: COSMIC-312 Phase III study design., PMID:32491932
Targeting MerTK Enhances Adaptive Immune Responses After Radiation Therapy., PMID:32311417
TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy., PMID:32087708
Increased sMer, but not sAxl, sTyro3, and Gas6 relate with active disease in juvenile systemic lupus erythematosus., PMID:31655933
A novel human anti-AXL monoclonal antibody attenuates tumour cell migration., PMID:31075180
Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer., PMID:30877108
TYRO3 as a molecular target for growth inhibition and apoptosis induction in bladder cancer., PMID:30765874
Differential Interaction of Platelet-Derived Extracellular Vesicles With Circulating Immune Cells: Roles of TAM Receptors, CD11b, and Phosphatidylserine., PMID:30619243
Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation., PMID:30541554
Leptospira species promote a pro-inflammatory phenotype in human neutrophils., PMID:30537301
MERTK Mediates Intrinsic and Adaptive Resistance to AXL-targeting Agents., PMID:30093568
TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus., PMID:29875238
Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis., PMID:29634284
Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma., PMID:29531161
Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers., PMID:29400409
Antiphospholipid Antibodies Inhibit Trophoblast Toll-Like Receptor and Inflammasome Negative Regulators., PMID:29342502
Cellular Targets and Receptor of Sexual Transmission of Zika Virus., PMID:28968270
TAM Receptors Are Not Required for Zika Virus Infection in Mice., PMID:28423319
Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor., PMID:28270700
TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy., PMID:28258690
Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies., PMID:28251492
Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression., PMID:28184013
Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response., PMID:27916840
Targeting the TAM Receptors in Leukemia., PMID:27834816
Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo., PMID:27170265
Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer., PMID:27132510
The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles., PMID:27006397
For research use only. Not for human or drug use.
