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Research Grade Anti-Human CD46 Antibody (FOR46)

Catalog #:   DHD11901 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD11901

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG

Target

Trophoblast leukocyte common antigen, CD46, TLX, MCP, Membrane cofactor protein, MIC10

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15529

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

FOR46, FOR 46, FOR-46

Clone ID

FOR46

Data Image
References

Evidence for Complement Activation in Preeclampsia Placenta and Its Presence in Circulation., PMID:40388260

The multiverse of CD46 and oncologic interactions., PMID:40309774

Complementing Anticancer Therapy: Antibody-Drug Conjugates Targeting CD46 as Prostate Cancer Treatment., PMID:40262077

Mechanism and regulation of the complement activity in kidney xenotransplantation., PMID:40233672

Targeting the tumour cell surface in advanced prostate cancer., PMID:40169837

Phase I, First-in-Human Study of FOR46 (FG-3246), an Immune-Modulating Antibody-Drug Conjugate Targeting CD46, in Patients With Metastatic Castration-Resistant Prostate Cancer., PMID:40138611

Atypical presentation of H1N1-induced thrombotic microangiopathy with CD46 gene mutation
., PMID:40115863

Claudin-2 enhances human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells by modulating antibody binding and complement activation., PMID:40040710

The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation., PMID:39902050

Complement-Mediated Hemolytic Uremic Syndrome Due to MCP/CD46 Mutation: A Case Report., PMID:39871416

Complement regulators as novel targets for anti-cancer therapy: A comprehensive review., PMID:39826189

Citrullinated IGF2BP1 promotes rheumatoid synovial aggression via increasing the mRNA stability of SEMA3D., PMID:39809921

Antibody‑drug conjugates in prostate cancer: Emerging strategies to enhance therapeutic index and current clinical landscape (Review)., PMID:39670293

A humanized neutralizing antibody protects against human adenovirus type 7 infection in humanized desmoglein-2 and CD46 double-receptor transgenic mice., PMID:39548554

The outer membrane protein, OMP71, of Riemerella anatipestifer, mediates adhesion and virulence by binding to CD46 in ducks., PMID:39407352

Unveiling the impact of Leptospira TolC efflux protein on host tissue adherence, complement evasion, and diagnostic potential., PMID:39392312

Complement biosensors identify a classical pathway stimulus in complement-mediated thrombotic microangiopathy., PMID:39357054

The intricate allostery in factor VIIa: triggering the trigger., PMID:39332529

Development of betabodies: The next generation of phosphatidylserine targeting agents., PMID:39159812

Protein-losing enteropathy as a new phenotype in atypical hemolytic uremic syndrome caused by CD46 gene mutation., PMID:39097532

Proximity Ligation Assay for the Analysis of Iron-Mediated Protein-Protein Interactions in the Nucleus., PMID:39008248

Feasibility study of ADCs targeting TROP-2, HER2, and CD46 in Ductal Adenocarcinoma and Intraductal Carcinoma of the prostate., PMID:38990246

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pig., PMID:38865482

Complement Biosensors Identify a Classical Pathway Stimulus in Complement-Mediated Hemolytic Uremic Syndrome., PMID:38854038

Anti-pig antibodies in swine veterinarian serum: Implications for clinical xenotransplantation., PMID:38853364

Dual topology of equine arteritis virus GP3 protein and the role of arginine motif RXR in GP3 ER retention., PMID:38850896

Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9., PMID:38847230

Adolescence-onset atypical hemolytic uremic syndrome: is it different from infant-onset?, PMID:38704765

A 21-bp deletion in the complement regulator CD55 promotor region is associated with multifocal motor neuropathy and its disease course., PMID:38528725

Development of CD46 targeted alpha theranostics in prostate cancer using 134Ce/225Ac-Macropa-PEG4-YS5., PMID:38389832

CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells., PMID:38361357

The complement cascade in lung injury and disease., PMID:38178176

Genetics and measles, mumps and rubella vaccine response in childhood and adolescence-A systematic review., PMID:38157324

CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma., PMID:38109209

CD46-ADC Reduces the Engraftment of Multiple Myeloma Patient-Derived Xenografts., PMID:38001595

Eculizumab Versus Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome: A Systematic Review., PMID:37905269

Complement-membrane regulatory proteins are absent from the nodes of Ranvier in the peripheral nervous system., PMID:37875972

Atypical hemolytic uremic syndrome: genetically-based insights into pathogenesis through an analysis of the complement regulator CD46., PMID:39949759

Exploring urinary extracellular vesicles for organ transplant monitoring: A comprehensive study for detection of allograft dysfunction using immune-specific markers., PMID:37633321

Comprehensive cell surface protein profiling of human mesenchymal stromal cells from peritoneal dialysis effluent and comparison with those from human bone marrow and adipose tissue., PMID:37603218

The association between CD46 expression in B cells and the pathogenesis of airway allergy., PMID:37579982

Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer., PMID:37468417

Membrane Cholesterol Inhibits Progesterone-Mediated Sperm Function through the Possible Involvement of ABHD2., PMID:37298205

Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization., PMID:37239846

HDAd6/35++ - A new helper-dependent adenovirus vector platform for in vivo transduction of hematopoietic stem cells., PMID:37081854

Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy., PMID:36917693

CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment., PMID:36906664

Detection of immunoreactive proteins of Escherichia coli, Streptococcus uberis, and Streptococcus agalactiae isolated from cows with diagnosed mastitis., PMID:36844415

Treatment of Human Pancreatic Cancers Following Local and Systemic Administration of Oncolytic Adenovirus Serotype 35., PMID:36697099

Variants in complement genes are uncommon in patients with anti-factor H autoantibody-associated atypical hemolytic uremic syndrome., PMID:36622444

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1486

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Research Grade Anti-Human CD46 Antibody (FOR46) [DHD11901]
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