Catalog No.
DHG02802
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Target
SKR1, Activin receptor type-1, Activin receptor-like kinase 2, TSR-I, ACVRLK2, ACTR-I, ALK-2, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I, ACVR1, Activin receptor type I
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q04771
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
DS-6016a, DS 6016a, DS6016a
Clone ID
DS-6016a
Emerging Therapeutic Approaches for Anemia in Myelofibrosis., PMID:40317385
Emerging Pathogenetic Mechanisms and New Drugs for Anemia in Myelofibrosis and Myelodysplastic Syndromes., PMID:40056069
Signaling Dynamics in Osteogenesis: Unraveling Therapeutic Targets for Bone Generation., PMID:39791147
Characterization of flare-ups and impact of garetosmab in adults with fibrodysplasia ossificans progressiva: a post hoc analysis of the randomized, double-blind, placebo-controlled LUMINA-1 trial., PMID:39216107
Hedgehog Signaling Controls Chondrogenesis and Ectopic Bone Formation via the Yap-Ihh Axis., PMID:38540766
Sex as a Critical Variable in Basic and Pre-Clinical Studies of Fibrodysplasia Ossificans Progressiva., PMID:38397414
How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva., PMID:38254701
ACVR1: A Novel Therapeutic Target to Treat Anemia in Myelofibrosis., PMID:38201581
A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders., PMID:37231012
Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology., PMID:35703179
Recent progress in drug development for fibrodysplasia ossificans progressiva., PMID:35536530
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1., PMID:35511419
An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice., PMID:35503416
Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival., PMID:34013359
Activin-A Induces Fewer, but Larger Osteoclasts From Monocytes in Both Healthy Controls and Fibrodysplasia Ossificans Progressiva Patients., PMID:32760351
Activin A does not drive post-traumatic heterotopic ossification., PMID:32553795
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop., PMID:32515349
Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity., PMID:30226468
Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP)., PMID:29170109
The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent., PMID:28782882
Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1., PMID:28642261
The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva., PMID:28629737
Autocrine and paracrine STIP1 signaling promote osteolytic bone metastasis in renal cell carcinoma., PMID:28199984
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A., PMID:26333933
HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells., PMID:26148958
BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse., PMID:25641697
Interaction of Tmem119 and the bone morphogenetic protein pathway in the commitment of myoblastic into osteoblastic cells., PMID:22579779
Immune responses to self-antigens in asthma patients: clinical and immunopathological implications., PMID:22386692
Conversion of vascular endothelial cells into multipotent stem-like cells., PMID:21102460
[BMP7 signaling via BMPR1A, BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell]., PMID:20673479
Myostatin inhibition by a follistatin-derived peptide ameliorates the pathophysiology of muscular dystrophy model mice., PMID:19108572
Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity., PMID:15693015
Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors., PMID:15459392
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo., PMID:12925698
For research use only. Not for human or drug use.
