Catalog No.
DHB94438
Expression system
Mammalian Cells
Species reactivity
Human
Isotype
Glycoprotein TNF-bp (Tumor necrosis factor-binding protein, TBP1)
Clonality
Monoclonal
Applications
Research Grade Biosimilar
Target
TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01375
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Onercept (USAN/INN), r-hTBP, R-HTBP-1, R-TBP-1, rTBP-1, TBP, TBP 1, TBP I, TNF-BP1, Tumour necrosis factor binding protein 1
Clone ID
Onercept
Note
For research use only. Not suitable for clinical or therapeutic use.
Effect of traumatic brain injury on cognitive function in mice lacking p55 and p75 tumor necrosis factor receptors., PMID:19388357
Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse., PMID:18201889
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis., PMID:18219394
Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice., PMID:18331798
Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure., PMID:18820134
Local ocular immunomodulation resulting from electrotransfer of plasmid encoding soluble TNF receptors in the ciliary muscle., PMID:19321795
Biological therapy of inflammatory bowel disease., PMID:19341184
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies., PMID:19404957
Advances of molecular clinical pharmacology in gastroenterology and hepatology., PMID:19433977
Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis., PMID:19440225
Toxoplasma gondii: the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection., PMID:19501090
[Perspectives in inflammatory bowel diseases treatment]., PMID:19606725
TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis., PMID:19635911
Lack of effect of TNFalpha blockade therapy on circulating adiponectin levels in patients with autoimmune disease: results from two independent prospective studies., PMID:19640853
Biologic targeting in the treatment of inflammatory bowel diseases., PMID:19707398
TNF receptor p55 and IL-8(72) and IL-8(77) isoforms: blood and urine levels in breast cancer patients., PMID:19908942
Endometriosis: in search of optimal treatment., PMID:20186112
Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform., PMID:20444945
Gastric and intestinal barrier impairment in tropical enteropathy and HIV: limited impact of micronutrient supplementation during a randomised controlled trial., PMID:20604937
Clinical development of onercept, a tumor necrosis factor binding protein, in psoriasis., PMID:20718590
Circulating TNF alpha receptor levels identify older adults who fail to regain weight after acute weight loss., PMID:20922351
Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide., PMID:21194425
Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice., PMID:21378027
Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling., PMID:21382533
TNFRp55 modulates IL-6 and nitric oxide responses following Yersinia lipopolysaccharide stimulation in peritoneal macrophages., PMID:21802165
Selective inhibition of intra-alveolar p55 TNF receptor attenuates ventilator-induced lung injury., PMID:22156959
Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17., PMID:22901753
TNFRp55 controls regulatory T cell responses in Yersinia-induced reactive arthritis., PMID:23207279
Tumor necrosis factor in traumatic brain injury: effects of genetic deletion of p55 or p75 receptor., PMID:23611870
Modulation of gut barrier function in patients with obstructive jaundice using probiotic LP299v., PMID:23820246
Amelioration of liver injury by continuously targeted intervention against TNFRp55 in rats with acute-on-chronic liver failure., PMID:23874752
HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity., PMID:24451118
New biologic therapeutics for ulcerative colitis and Crohn's disease., PMID:24502344
Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis., PMID:24569452
Bone mineral density and bone turnover in non-cirrhotic patients with chronic hepatitis C and sustained virological response to antiviral therapy with peginterferon-alfa and ribavirin., PMID:24676843
Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania (Leishmania) amazonensis., PMID:24856420
Decrease in neuroimmune activation by HSV-mediated gene transfer of TNFα soluble receptor alleviates pain in rats with diabetic neuropathy., PMID:24880032
The interaction between menstrual cycle, Tumour Necrosis Factor alpha receptors and sex hormones in healthy non-obese women--results from an observational study., PMID:25292131
Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration., PMID:26708145
Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease., PMID:26896086
TNFRp55 deficiency promotes the development of ectopic endometriotic-like lesions in mice., PMID:28676525
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts., PMID:29434332
IL-12/23p40 overproduction by dendritic cells leads to an increased Th1 and Th17 polarization in a model of Yersinia enterocolitica-induced reactive arthritis in TNFRp55-/- mice., PMID:29494692
Circadian rhythms of factors involved in luteal regression are modified in p55 tumour necrosis factor receptor (TNFRp55)-deficient mice., PMID:29903342
Non-viral ocular gene therapy, pEYS606, for the treatment of non-infectious uveitis: Preclinical evaluation of the medicinal product., PMID:30009894
Peripheral Neuroimmunoendocrine Interactions: Contribution of TNFRp55 to the Circadian Synchronization of Progesterone and Cytokine Production in Joints of Mice in Late Pregnancy., PMID:30304732
Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile., PMID:30732877
Reduced inflammatory state promotes reinnervation of endometriotic-like lesions in TNFRp55 deficient mice., PMID:31070761
Dendritic Cells of Mesenteric and Regional Lymph Nodes Contribute to Yersinia enterocolitica O:3-Induced Reactive Arthritis in TNFRp55-/- Mice., PMID:32122996
TNFRp75-dependent immune regulation of alveolar macrophages and neutrophils during early Mycobacterium tuberculosis and Mycobacterium bovis BCG infection., PMID:33020922
For research use only. Not for human or drug use.
