Catalog No.
DHB94438
Expression system
Mammalian Cells
Species reactivity
Human
Isotype
Glycoprotein TNF-bp (Tumor necrosis factor-binding protein, TBP1)
Clonality
Monoclonal
Target
TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01375
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Onercept (USAN/INN), r-hTBP, R-HTBP-1, R-TBP-1, rTBP-1, TBP, TBP 1, TBP I, TNF-BP1, Tumour necrosis factor binding protein 1
Clone ID
Onercept
TNFRp75-dependent immune regulation of alveolar macrophages and neutrophils during early Mycobacterium tuberculosis and Mycobacterium bovis BCG infection., PMID:33020922
Dendritic Cells of Mesenteric and Regional Lymph Nodes Contribute to Yersinia enterocolitica O:3-Induced Reactive Arthritis in TNFRp55-/- Mice., PMID:32122996
Reduced inflammatory state promotes reinnervation of endometriotic-like lesions in TNFRp55 deficient mice., PMID:31070761
Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile., PMID:30732877
Peripheral Neuroimmunoendocrine Interactions: Contribution of TNFRp55 to the Circadian Synchronization of Progesterone and Cytokine Production in Joints of Mice in Late Pregnancy., PMID:30304732
Non-viral ocular gene therapy, pEYS606, for the treatment of non-infectious uveitis: Preclinical evaluation of the medicinal product., PMID:30009894
Circadian rhythms of factors involved in luteal regression are modified in p55 tumour necrosis factor receptor (TNFRp55)-deficient mice., PMID:29903342
IL-12/23p40 overproduction by dendritic cells leads to an increased Th1 and Th17 polarization in a model of Yersinia enterocolitica-induced reactive arthritis in TNFRp55-/- mice., PMID:29494692
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts., PMID:29434332
TNFRp55 deficiency promotes the development of ectopic endometriotic-like lesions in mice., PMID:28676525
Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease., PMID:26896086
Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration., PMID:26708145
The interaction between menstrual cycle, Tumour Necrosis Factor alpha receptors and sex hormones in healthy non-obese women--results from an observational study., PMID:25292131
Decrease in neuroimmune activation by HSV-mediated gene transfer of TNFα soluble receptor alleviates pain in rats with diabetic neuropathy., PMID:24880032
Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania (Leishmania) amazonensis., PMID:24856420
Bone mineral density and bone turnover in non-cirrhotic patients with chronic hepatitis C and sustained virological response to antiviral therapy with peginterferon-alfa and ribavirin., PMID:24676843
Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis., PMID:24569452
New biologic therapeutics for ulcerative colitis and Crohn's disease., PMID:24502344
HSV-mediated p55TNFSR reduces neuropathic pain induced by HIV gp120 in rats through CXCR4 activity., PMID:24451118
Amelioration of liver injury by continuously targeted intervention against TNFRp55 in rats with acute-on-chronic liver failure., PMID:23874752
Modulation of gut barrier function in patients with obstructive jaundice using probiotic LP299v., PMID:23820246
Tumor necrosis factor in traumatic brain injury: effects of genetic deletion of p55 or p75 receptor., PMID:23611870
TNFRp55 controls regulatory T cell responses in Yersinia-induced reactive arthritis., PMID:23207279
Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17., PMID:22901753
Selective inhibition of intra-alveolar p55 TNF receptor attenuates ventilator-induced lung injury., PMID:22156959
TNFRp55 modulates IL-6 and nitric oxide responses following Yersinia lipopolysaccharide stimulation in peritoneal macrophages., PMID:21802165
Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling., PMID:21382533
Characterization of TNF receptor subtype expression and signaling on pulmonary endothelial cells in mice., PMID:21378027
Kinin B1 receptors mediate depression-like behavior response in stressed mice treated with systemic E. coli lipopolysaccharide., PMID:21194425
Circulating TNF alpha receptor levels identify older adults who fail to regain weight after acute weight loss., PMID:20922351
Clinical development of onercept, a tumor necrosis factor binding protein, in psoriasis., PMID:20718590
Gastric and intestinal barrier impairment in tropical enteropathy and HIV: limited impact of micronutrient supplementation during a randomised controlled trial., PMID:20604937
Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform., PMID:20444945
Endometriosis: in search of optimal treatment., PMID:20186112
TNF receptor p55 and IL-8(72) and IL-8(77) isoforms: blood and urine levels in breast cancer patients., PMID:19908942
Biologic targeting in the treatment of inflammatory bowel diseases., PMID:19707398
Lack of effect of TNFalpha blockade therapy on circulating adiponectin levels in patients with autoimmune disease: results from two independent prospective studies., PMID:19640853
TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis., PMID:19635911
[Perspectives in inflammatory bowel diseases treatment]., PMID:19606725
Toxoplasma gondii: the role of IFN-gamma, TNFRp55 and iNOS in inflammatory changes during infection., PMID:19501090
Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis., PMID:19440225
Advances of molecular clinical pharmacology in gastroenterology and hepatology., PMID:19433977
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies., PMID:19404957
Biological therapy of inflammatory bowel disease., PMID:19341184
Local ocular immunomodulation resulting from electrotransfer of plasmid encoding soluble TNF receptors in the ciliary muscle., PMID:19321795
Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure., PMID:18820134
Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I:C) in D-galactosamine-sensitized mice., PMID:18331798
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis., PMID:18219394
Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse., PMID:18201889
Effect of traumatic brain injury on cognitive function in mice lacking p55 and p75 tumor necrosis factor receptors., PMID:19388357
For research use only. Not for human or drug use.
