Catalog No.
DHF05302
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Tyrosine-protein kinase receptor SEK, Tyrosine-protein kinase TYRO1, Ephrin type-A receptor 4, TYRO1, EPHA4, EPH-like kinase 8, hEK8, SEK, EK8, HEK8
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P54764
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
MEDI-542, MEDI542, MEDI 542
Clone ID
MEDI-542
Eph Receptor Tyrosine Kinases Are Functional Entry Receptors for Murine Gammaherpesvirus 68., PMID:40501621
Evaluation of NUN-004, a Novel Engineered Ephrin Antagonist, in Healthy Volunteers and Patients with Amyotrophic Lateral Sclerosis: A Phase I/Ib, Open-Label, Escalating Dose and Extended Access Study., PMID:39621188
EphA4 Targeting Peptide-Conjugated Extracellular Vesicles Rejuvenates Adult Neural Stem Cells and Exerts Therapeutic Benefits in Aging Rats., PMID:39288278
The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression., PMID:39211197
Corrigendum to "Single-chain fragment antibody disrupting the EphA4 function as a therapeutic drug for gastric cancer" [Biochem. Biophys. Res. Commun. 680 (2023) 161-170]., PMID:37839952
Single-chain fragment antibody disrupting the EphA4 function as a therapeutic drug for gastric cancer., PMID:37741263
Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome., PMID:37587118
Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice., PMID:33410216
EPHA4 regulates vascular smooth muscle cell contractility and is a sex-specific hypertension risk gene in individuals with type 2 diabetes., PMID:30817459
RANKL, Ephrin-Eph and Wnt10b are key intercellular communication molecules regulating bone remodeling in autologous transplanted goldfish scales., PMID:29886255
Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus., PMID:29292384
EphA4 protein promotes invasion in clear cell renal cell carcinomas., PMID:31966534
High expression of EphA4 is associated with invasion and lymph node metastasis in colorectal carcinomas., PMID:31966851
Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist., PMID:28747680
Identification and characterization of Nanobodies targeting the EphA4 receptor., PMID:28526745
Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery., PMID:28165374
[Estimation of the diagnostic potential of APOD, PTOV1, and EPHA4 for prostatic neoplasms]., PMID:27804940
EPHA4-FC TREATMENT REDUCES ISCHEMIA/REPERFUSION-INDUCED INTESTINAL INJURY BY INHIBITING VASCULAR PERMEABILITY., PMID:26771935
Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination., PMID:26687980
EPHA4 is overexpressed but not functionally active in Sézary syndrome., PMID:26376612
Development of a Trispecific Antibody Designed to Simultaneously and Efficiently Target Three Different Antigens on Tumor Cells., PMID:26176328
Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling., PMID:25758863
Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation., PMID:25556233
Characterization of cytoplasmic polyadenylation element binding 2 protein expression and its RNA binding activity., PMID:25483308
Ephrin-A2 and -A3 are negative regulators of the regenerative potential of Möller cells., PMID:25269910
Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration., PMID:24103058
Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats., PMID:23557244
EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE)., PMID:23390555
Partial change in EphA4 knockout mouse phenotype: loss of diminished GFAP upregulation following spinal cord injury., PMID:22824304
The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments., PMID:22670058
EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice., PMID:21931787
Intramyocardial administration of chimeric ephrinA1-Fc promotes tissue salvage following myocardial infarction in mice., PMID:21282286
Preparation of mouse brain tissue for immunoelectron microscopy., PMID:20689505
Developmental expression of Eph and ephrin family genes in mammalian small intestine., PMID:20112066
EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain., PMID:20067584
Expression of PTPRO in the interneurons of adult mouse olfactory bulb., PMID:19924828
A review of published reports on neuroprotection in spinal cord injury., PMID:19597522
Upregulation of EphB2 and ephrin-B2 at the optic nerve head of DBA/2J glaucomatous mice coincides with axon loss., PMID:18055806
Venous identity is lost but arterial identity is not gained during vein graft adaptation., PMID:17463332
Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus., PMID:17299751
Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain., PMID:16959251
Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains., PMID:16365308
[Preparation and analysis of monoclonal antibody against EphA4 peptide]., PMID:16320581
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets., PMID:15994237
Paraplegic mice are leading to new advances in spinal cord injury research., PMID:15809672
Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection., PMID:15681844
Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice., PMID:15537875
Human dendritic cells express neuronal Eph receptor tyrosine kinases: role of EphA2 in regulating adhesion to fibronectin., PMID:12907451
EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells., PMID:12775584
EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and -B3., PMID:12761826
For research use only. Not for human or drug use.
