Catalog No.
FHC13160
Species reactivity
Human
Host species
Human
Isotype
IgG4
Clonality
Monoclonal
Conjugation
Unconjugated
Target
Complement receptor C3 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Integrin beta-2, MFI7, CD18, ITGB2, CD11A, Leukocyte function-associated molecule 1 alpha chain, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, CD11 antigen-like family member A, CD11a, ITGAL, Integrin alpha-L
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05107 & P20701
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
23F2G
MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases., PMID:40312574
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells., PMID:39885580
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice., PMID:39841806
CD47-SIRPα Blockade Sensitizes Head and Neck Squamous Cell Carcinoma to Cetuximab by Enhancing Macrophage Adhesion to Cancer Cells., PMID:38959336
Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15., PMID:36944397
Allosteric targeting resolves limitations of earlier LFA-1 directed modalities., PMID:36921634
The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation., PMID:36796515
β2-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response., PMID:36139397
Repeated Social Defeat Exaggerates Fibrin-Rich Clot Formation by Enhancing Neutrophil Extracellular Trap Formation via Platelet-Neutrophil Interactions., PMID:34943852
Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro., PMID:34721399
The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils., PMID:34435628
Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK., PMID:34338598
G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment., PMID:34049929
Identification of neutrophil β2-integrin LFA-1 as a potential mechanistic biomarker in ANCA-associated vasculitis via microarray and validation analyses., PMID:33957974
β2 Integrin Signaling Cascade in Neutrophils: More Than a Single Function., PMID:33679708
Actinobacillus pleuropneumoniae exotoxin ApxI induces cell death via attenuation of FAK through LFA-1., PMID:33462305
Kindlin3-Dependent CD11b/CD18-Integrin Activation Is Required for Potentiation of Neutrophil Cytotoxicity by CD47-SIRPα Checkpoint Disruption., PMID:33355195
Monoclonal Antibody to CD14, TLR4, or CD11b: Impact of Epitope and Isotype Specificity on ROS Generation by Human Granulocytes and Monocytes., PMID:33294123
Activated Human Memory B Lymphocytes Use CR4 (CD11c/CD18) for Adhesion, Migration, and Proliferation., PMID:33133077
Increased Complement Receptor-3 levels in monocytes and granulocytes distinguish COVID-19 patients with pneumonia from those with mild symptoms., PMID:32771640
Complement Receptor 3 Contributes to the Sexual Dimorphism in Neutrophil Killing of Staphylococcus aureus., PMID:32769122
The integrin-linked kinase is required for chemokine-triggered high-affinity conformation of the neutrophil β2-integrin LFA-1., PMID:32730588
Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo., PMID:32561828
Molecular mechanism of leukocidin GH-integrin CD11b/CD18 recognition and species specificity., PMID:31852826
JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation., PMID:30024857
Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis., PMID:29949776
The effectiveness of the anti-CD11d treatment is reduced in rat models of spinal cord injury that produce significant levels of intraspinal hemorrhage., PMID:28587875
Mutation characterization and heterodimer analysis of patients with leukocyte adhesion deficiency: Including one novel mutation., PMID:28445705
Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys., PMID:28071653
Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO)., PMID:27853810
Neutrophil Receptor Response to Bacterial N-formyl Peptides is Similar in Term Newborn Infants and Adults in Contrast to IL-8., PMID:27606963
The Role of Integrins αMβ2 (Mac-1, CD11b/CD18) and αDβ2 (CD11d/CD18) in Macrophage Fusion., PMID:27315778
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation., PMID:26993426
IgM-Dependent Phagocytosis in Microglia Is Mediated by Complement Receptor 3, Not Fcα/μ Receptor., PMID:26500348
Visualization of integrin Mac-1 in vivo., PMID:26342259
Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)., PMID:26306739
Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18., PMID:26293614
Increasing the potency of neutralizing single-domain antibodies by functionalization with a CD11b/CD18 binding domain., PMID:26192995
CD11d integrin blockade reduces the systemic inflammatory response syndrome after traumatic brain injury in rats., PMID:26169930
Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function-Associated Antigen-1 and Kindlin-3., PMID:25987740
Choline Transporter-Like Protein-2: New von Willebrand Factor-Binding Partner Involved in Antibody-Mediated Neutrophil Activation and Transfusion-Related Acute Lung Injury., PMID:25931511
Monoclonal and Single Domain Antibodies Targeting β-Integrin Subunits Block Sexual Transmission of HIV-1 in In Vitro and In Vivo Model Systems., PMID:25828964
Streamlined method for parallel identification of single domain antibodies to membrane receptors on whole cells., PMID:25819371
Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin., PMID:25727181
The CD markers of camel (Camelus dromedarius) milk cells during mastitis: the LPAM-1 expression is an indication of possible mucosal nature of the cellular trafficking., PMID:25666226
Phenotypic and functional analysis of HL-60 cells used in opsonophagocytic-killing assay for Streptococcus pneumoniae., PMID:25653484
CD11b is protective in complement-mediated immune complex glomerulonephritis., PMID:25565310
Role of CD11b/CD18 in priming of human leukocytes by endotoxin glycoforms from Escherichia coli., PMID:25365491
Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1., PMID:25024378
Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss., PMID:24670684
For research use only. Not for human or drug use.
