Anti-Mouse BCAR1 Polyclonal Antibody

Catalog No.

PMF20201

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse BCAR1 (Thr2-Met66).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, p130cas, Bcar1, Cas, Crkas

Purification

Purified by antigen affinity column.

Accession

Q61140

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Modeling ErbB2-p130Cas interaction to design new potential anticancer agents., PMID:30816273

Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?, PMID:25599124

SRChing for the substrates of Src., PMID:24121272

Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer., PMID:23701402

Impaired c-src activation and motility defects in PEA3-null fibroblasts., PMID:22982417

Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines., PMID:22328489

BCAR1 expression improves prediction of biochemical reccurence after radical prostatectomy., PMID:22241677

Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death., PMID:21957230

p130Cas, E-cadherin and β-catenin in human transitional cell carcinoma of the bladder: expression and clinicopathological significance., PMID:21672035

Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans., PMID:21501079

Expression of estrogen related proteins in hormone refractory prostate cancer: association with tumor progression., PMID:20850840

v-Crk induces Rac-dependent membrane ruffling and cell migration in CAS-deficient embryonic fibroblasts., PMID:18319625

Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells., PMID:18078823

AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma., PMID:17876044

Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy., PMID:17185516

Immunotherapy of melanoma targeting human high molecular weight melanoma-associated antigen: potential role of nonimmunological mechanisms., PMID:15650259

A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling., PMID:15647274

Development of an ELISA for measurement of BCAR1 protein in human breast cancer tissue., PMID:15277346

The integrin beta1 subunit transmembrane domain regulates phosphatidylinositol 3-kinase-dependent tyrosine phosphorylation of Crk-associated substrate., PMID:15034138

Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro., PMID:14703945

The cholecystokinin system in the rat retina: receptor expression and in vivo activation of tyrosine phosphorylation pathways., PMID:14698681

Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase., PMID:12844492

Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by alpha2beta1 integrin., PMID:12676963

The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42., PMID:12517963

Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas., PMID:12401522

STAT3 deficiency in keratinocytes leads to compromised cell migration through hyperphosphorylation of p130(cas)., PMID:11812786

Immunohistochemical study of the BCAR1/p130Cas protein in non-malignant and malignant human breast tissue., PMID:11605729

CD2AP and p130Cas localize to different F-actin structures in podocytes., PMID:11553524

Degradation of focal adhesion proteins paxillin and p130cas by caspases or calpains in apoptotic rat-1 and L929 cells., PMID:11511102

Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies., PMID:11420674

RhoA is activated during respiratory syncytial virus infection., PMID:11336544

Serine phosphorylation of focal adhesion kinase in interphase and mitosis: a possible role in modulating binding to p130(Cas)., PMID:11160818

SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading., PMID:11158326

Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas)., PMID:11118637

Contortrostatin, a snake venom disintegrin, induces alphavbeta3-mediated tyrosine phosphorylation of CAS and FAK in tumor cells., PMID:10906753

Identification of p130cas as an in vivo substrate of receptor protein-tyrosine phosphatase alpha., PMID:10787408

Expression of integrin subunit beta1B in integrin beta1-deficient GD25 cells does not interfere with alphaVbeta3 functions., PMID:10623465

Platelet-activating factor stimulation of p125(FAK) and p130(Cas) tyrosine phosphorylation in brain., PMID:10415383

Soluble collagen VI induces tyrosine phosphorylation of paxillin and focal adhesion kinase and activates the MAP kinase erk2 in fibroblasts., PMID:10413607

p130cas is a cellular target protein for tyrosine nitration induced by peroxynitrite., PMID:10401986

Physiological signals and oncogenesis mediated through Crk family adapter proteins., PMID:10092207

Expression of Src family kinases and their putative substrates in the human preosteoclastic cell line FLG 29.1., PMID:9844106

Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts., PMID:9556601

Depolarization-induced tyrosine phosphorylation of p130(cas)., PMID:9538253

Detection of distinct pools of the adapter protein p130CAS using a panel of monoclonal antibodies., PMID:9388023

Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors., PMID:9348226

Requirements for localization of p130cas to focal adhesions., PMID:9199323

Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions., PMID:9184219

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells., PMID:9020138

The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas., PMID:8995252

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