Catalog No.
PME23501
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse CDKN1A (Ser2-Pro159).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1
Purification
Purified by antigen affinity column.
Accession
P39689
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial., PMID:40414961
Selective USP7 Inhibition Synergizes with MEK1/2 Inhibitor to Enhance Immune Responses and Potentiate Anti-PD-1 Therapy in NRAS-Mutant Melanoma., PMID:40204067
EZH2 promotes B-cell autoimmunity in primary Sjogren's syndrome via METTL3-mediated m6A modification., PMID:39577129
Characteristics of T cell premature senescence in maintenance hemodialysis patients., PMID:38850344
Transcriptomic signatures of classical monocytes reveal pro-inflammatory modules and heterogeneity in polyarticular juvenile idiopathic arthritis., PMID:38835762
The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration., PMID:38614205
Selectively targeting BCL6 using a small molecule inhibitor is a potential therapeutic strategy for ovarian cancer., PMID:38169532
Specific serum autoantibodies predict the development and progression of Alzheimer's disease with high accuracy., PMID:37989443
Podocyte injury at young age causes premature senescence and worsens glomerular aging., PMID:37855038
Polymorphism at codon 31 of CDKN1A (p21) as a predictive factor for bevacizumab therapy in glioblastoma multiforme., PMID:37730565
Baseline tumor gene expression signatures correlate with chemoimmunotherapy treatment responsiveness in canine B cell lymphoma., PMID:37624862
Green tea EGCG inhibits naïve CD4+ T cell division and progression in mice: An integration of network pharmacology, molecular docking and experimental validation., PMID:37441168
Anti-Proliferative Effect of Radiotherapy and Implication of Immunotherapy in Anaplastic Thyroid Cancer Cells., PMID:37374179
Role of MXRA8 in Ross River Virus Disease Pathogenesis., PMID:37036079
Extracellular vesicles derived from patients with antibody-mediated rejection induce tubular senescence and endothelial to mesenchymal transition in renal cells., PMID:35583104
PEG-4000 formed polymeric nanoparticles loaded with cetuximab downregulate p21 & stathmin-1 gene expression in cancer cell lines., PMID:35176277
Promotion of Cervical Cancer Cell Proliferation by miR-130b Expression Level Changes and Inhibition of its Apoptosis by Targeting CDKN1A Gene., PMID:35016595
Quantitative single-cell analysis of immunofluorescence protein multiplex images illustrates biomarker spatial heterogeneity within breast cancer subtypes., PMID:34922607
Molecular Response to Combined Molecular- and External Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC)., PMID:34830750
Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence., PMID:34580063
Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells., PMID:34469723
Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21cip1 expression., PMID:34339841
B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation., PMID:33900379
Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung., PMID:33731112
Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam., PMID:33687153
p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model., PMID:33484913
Restriction Factor Expression in Vertically Infected Children Living With HIV-1., PMID:33395209
Comparison of senescence progression in mesenchymal cells from human umbilical cord walls measured by immunofluorescence and flow cytometry of p16 and p21., PMID:33084793
PHF14 is required for germinal center B cell development., PMID:33035772
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis., PMID:32955487
Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow., PMID:31462901
Mast cell chymase in synovial fluid of collagen-induced-arthritis rats regulates gelatinase release and promotes synovial fibroblasts proliferation via FAK/p21 signaling pathway., PMID:31036322
Polymorphism rs2395655 affects LEDGF/p75 binding activity and p21WAF1/CIP1 gene expression in esophageal squamous cell carcinoma., PMID:30854807
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways., PMID:30597146
Differential time-dependent transcriptional changes in the osteoblast lineage in cortical bone associated with sclerostin antibody treatment in ovariectomized rats., PMID:29955627
Decreased osteoprogenitor proliferation precedes attenuation of cancellous bone formation in ovariectomized rats treated with sclerostin antibody., PMID:29955626
A correlation of immunohistochemical expression of TP53 and CDKN1A in oral epithelial dysplasia and oral squamous cell carcinoma., PMID:29893337
Novel role of prostate apoptosis response-4 tumor suppressor in B-cell chronic lymphocytic leukemia., PMID:29695515
Histone deacetylase inhibitor-based chromatin precipitation for identification of targeted genomic loci., PMID:29682593
Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection., PMID:29618490
Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors., PMID:29540581
Senescence-associated secretory factors induced by cisplatin in melanoma cells promote non-senescent melanoma cell growth through activation of the ERK1/2-RSK1 pathway., PMID:29449532
Prediction of novel target genes and pathways involved in bevacizumab-resistant colorectal cancer., PMID:29342159
Histone deacetylase inhibitor (HDACi) upregulates activin A and activates the Smad signaling pathway in melanomas., PMID:29290529
Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells., PMID:29100552
Different patterns of expression of cell cycle control and local invasion-related proteins in oral squamous cell carcinoma affecting young patients., PMID:28626969
Mycoplasma fermentans deacetylase promotes mammalian cell stress tolerance., PMID:28602396
Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α., PMID:28406729
Protective effects of Polypodium leucotomos extract against UVB-induced damage in a model of reconstructed human epidermis., PMID:28140474
Mitotic catastrophe and cell cycle arrest are alternative cell death pathways executed by bortezomib in rituximab resistant B-cell lymphoma cells., PMID:28055975
For research use only. Not for human or drug use.
