Catalog No.
PME01401
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse DSG3 (Asn151-Asp591).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Desmoglein-3, 130 kDa pemphigus vulgaris antigen homolog, Dsg3
Purification
Purified by antigen affinity column.
Accession
O35902
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study., PMID:40481453
Factors associated with persistent anti-desmoglein positivity after remission in pemphigus vulgaris: a prospective registry-based cohort study., PMID:40433384
Epac1 contributes to apremilast-mediated rescue of pemphigus autoantibody-induced loss of keratinocyte adhesion., PMID:40299565
Elevated Fab glycosylation of autoantibodies maintained during B cell depletion therapy., PMID:40295683
In desmosomes direct inhibition precedes p38MAPK-mediated uncoupling to reduce Dsg3 adhesion by pemphigus autoantibodies., PMID:40264374
Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor., PMID:40120680
Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus., PMID:40059466
Prevalence and pathogenic activity of anti-desmocollin-3 antibodies in patients with pemphigus vulgaris and pemphigus foliaceus., PMID:39989391
Optimizing Pemphigus Management With Rituximab and Short-Term Relapse Predictors., PMID:39908046
The impact of signaling pathways on the desmosome ultrastructure in pemphigus., PMID:39882246
Case report: A rollercoaster journey of pemphigus vegetans., PMID:39872528
Pemphigus relapse: Mechanisms, risk factors, and agents associated with disease recurrence., PMID:39460496
Quality-controlled characterization of a monoclonal antibody specific to an EC5-domain of human desmoglein 3 for pemphigus research., PMID:39450179
IgG reactivity to different desmoglein-3 ectodomains in pemphigus vulgaris: novel panels for assessing disease severity., PMID:39416775
Human dental mesenchymal stem cells restorate immune response in sera of pemphigus vulgaris patients., PMID:39352524
Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus., PMID:39271654
Comparison of serum cytokines and chemokines levels and clinical significance in patients with pemphigus vulgaris-A retrospective study., PMID:39246287
Standardized Production of Anti-Desmoglein 3 Antibody AK23 for Translational Pemphigus Vulgaris Research., PMID:39169810
Pathogenic relevance of antibodies against desmoglein 3 in patients with oral lichen planus., PMID:39152677
Case report: Managing pemphigus foliaceus using apremilast without systemic glucocorticosteroids or immunosuppressive agents., PMID:39139566
Direct immunofluorescence on plucked hair outer root sheath can predict relapse in pemphigus vulgaris., PMID:39086016
Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris., PMID:39037929
Activity of apremilast in a patient with severe pemphigus vulgaris: case report., PMID:38983857
Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus., PMID:38851894
The emergence of circulating activated autoreactive desmoglein 3-specific follicular regulatory T cells is associated with long-term efficacy of rituximab in patients with pemphigus vulgaris., PMID:38848544
Absence of Epidermal Antibodies in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Patients but Beware of Single Positive Results., PMID:38803350
Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions., PMID:38766211
A case of bullous pemphigoid complicated by mucosal lesions due to mucosal-dominant pemphigus vulgaris: analyzing the pathogenicity of anti-desmoglein 3 antibodies using a bead aggregation assay., PMID:38741281
Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus., PMID:38677661
EGFR Inhibition by Erlotinib Rescues Desmosome Ultrastructure and Keratin Anchorage and Protects against Pemphigus Vulgaris IgG-Induced Acantholysis in Human Epidermis., PMID:38642796
Clinical and immunological predictors of post-rituximab paradoxical pemphigus flare: A prospective cohort study., PMID:38595008
Differences among Indian and European pemphigus patients based on demographics, clinical parameters and propensity for relapse: results of a prospective bicontinental cohort study., PMID:38465545
The Need of Differential Diagnosis Between Vulvar Lichen Sclerosus and Autoimmune Dermatoses in Adolescent Girls., PMID:38451422
Rituximab in the Management of Autoimmune Bullous Diseases: A Treatment-Resistant Case Series from a Single Central European Referral Center., PMID:38399557
Sustained Remission Without Corticosteroids Among Patients With Pemphigus Who Had Rituximab as First-Line Therapy: Follow-Up of the Ritux 3 Trial., PMID:38265821
Novel nanoparticle AuNCs conjugated with Desmoglein-3 antibody for FL/CT dual-mode targeted imaging and precise treatment of lung squamous cell carcinoma., PMID:38224630
A case of anti-laminin γ1 (p200) pemphigoid developed after dipeptidyl peptidase-4 inhibitor administration., PMID:38214494
Pemphigus vulgaris relapsed with serological shift from single-positive desmoglein-3 antibodies to single-positive desmoglein-1 antibodies., PMID:38212901
A case of paraneoplastic pemphigus associated with follicular lymphoma positive only for anti-desmoglein 3 antibody., PMID:38111329
Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation., PMID:37940861
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88., PMID:37719363
Type 2 T-Cell Responses against Distinct Epitopes of the Desmoglein 3 Ectodomain in Pemphigus Vulgaris., PMID:37717934
Serologic Biomarkers in Pemphigus Monitoring: C-reactive Protein, Macrophage Migration Inhibitory Factor, and Prolactin Levels Versus Autoantibody Assays., PMID:37524667
Plasma Exosomal microRNA Profile Reveals miRNA 148a-3p Downregulation in the Mucosal-Dominant Variant of Pemphigus Vulgaris., PMID:37511259
Efficacy of anti-desmoglein 1 and anti-desmoglein 3 levels by enzyme-linked immunosorbent assay compared to biopsy of chronic oral ulcerative diseases with positive Nikolsky's sign to diagnose oral pemphigus vulgaris with or without skin involvement: a retrospective institutional observational pilot study., PMID:37507320
Blocking soluble Fas Ligand ameliorates pemphigus: PC111 efficacy in ex-vivo human pemphigus models., PMID:37503332
Two cases of cutaneous-type pemphigus vulgaris and a case of pemphigus foliaceus without mucosal involvement despite high anti-desmoglein 3 autoantibody levels., PMID:37485682
Skin-infiltrating T cells display distinct inflammatory signatures in lichen planus, bullous pemphigoid and pemphigus vulgaris., PMID:37415985
Treatment-naïve pemphigus patients showing IgG tissue deposits have serum IgG antibodies against desmoglein 1 detected more often than those against desmoglein 3: a monocentre laboratory experience., PMID:37312921
Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte dissociation via upregulation of Caveolin-1 and inhibition of the STAT3 pathway., PMID:37262304
For research use only. Not for human or drug use.
