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Anti-Mouse CASP1/Caspase-1 Polyclonal Antibody

Catalog #:   PMD84101 Specific References (50) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P29452
Overview

Catalog No.

PMD84101

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CASP1/Caspase-1 (Leu137-His402).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Caspase-1, CASP-1, 3.4.22.36, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, Casp1, Il1bc

Purification

Purified by antigen affinity column.

Accession

P29452

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • Western Blot
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with CASP1/Caspase-1 antibody (PMD84101) at 1 µg/ml.

    Lane 1: Recombinant Protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 33 kDa
    Observed MW: 33 kDa
References

HERV-W Env Induces Neuron Pyroptosis via the NLRP3-CASP1-GSDMD Pathway in Recent-Onset Schizophrenia., PMID:39859234

Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes., PMID:39716335

Particulate Matter Induces NLRP3 Inflammasome-Mediated Pyroptosis in Human Nasal Epithelial Cells., PMID:39664405

Allergy and autoinflammation drive persistent systemic inflammatory response in Meniere Disease: A longitudinal study., PMID:39622350

Effect and Mechanism of Mycobacterium avium MAV-5183 on Apoptosis of Mouse Ana-1 Macrophages., PMID:38430410

Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19., PMID:36881624

Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury., PMID:36635478

Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy., PMID:36531688

Lung Inflammasome Activation in SARS-CoV-2 Post-Mortem Biopsies., PMID:36361818

Exploring the relationship between pyroptosis, infiltrating immune cells and Kawasaki disease with resistance to intravenous immunoglobulin (IVIG) via bioinformatic analysis., PMID:36029669

Intestinal Epithelial Responses to IL-17 in Adult Stem Cell-derived Human Intestinal Organoids., PMID:35927216

Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity., PMID:35414518

Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway., PMID:34950139

Artificial Neural Networks Predicted the Overall Survival and Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Pancancer Immune-Oncology Panel., PMID:34945004

Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries., PMID:34822855

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization., PMID:34802379

Cytotoxin-associated gene A (CagA) promotes aortic endothelial inflammation and accelerates atherosclerosis through the NLRP3/caspase-1/IL-1β axis., PMID:34670018

Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway., PMID:34614429

VaximmutorDB: A Web-Based Vaccine Immune Factor Database and Its Application for Understanding Vaccine-Induced Immune Mechanisms., PMID:33777032

Cryptococcus neoformans Secretes Small Molecules That Inhibit IL-1β Inflammasome-Dependent Secretion., PMID:33380899

Long noncoding RNA MIAT regulates primary human retinal pericyte pyroptosis by modulating miR-342-3p targeting of CASP1 in diabetic retinopathy., PMID:33065089

Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes., PMID:32731050

Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity., PMID:32332737

No Major Effect of Innate Immune Genetics on Acute Kidney Rejection in the First 2 Weeks Post-Transplantation., PMID:32153387

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation., PMID:32019420

Lipoxin A4 suppresses angiotensin II type 1 receptor autoantibody in preeclampsia via modulating caspase-1., PMID:32001671

Signature of genome wide gene expression in classical swine fever virus infected macrophages and PBMCs of indigenous vis-a-vis crossbred pigs., PMID:31935504

Inflammasome Activation in Human Macrophages Induced by a LDL (-) Mimetic Peptide., PMID:31858317

FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses., PMID:31488506

Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)., PMID:31445901

MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1β release in mice., PMID:31100367

Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392

Pannexin 1 Channels Contribute to IL-1β Expression via NLRP3/Caspase-1 Inflammasome in Aspergillus Fumigatus Keratitis., PMID:30793631

Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV., PMID:30634407

Inflammatory Mediator Expression Associated With Antibody Response Induced by Live Attenuated vs Inactivated Influenza Virus Vaccine in Children., PMID:30515427

Effect of massage therapy by VOSKIN 125+ painkiller® on inflammatory skin lesions., PMID:30133870

Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation., PMID:30019185

mTORC2 Activity Disrupts Lysosome Acidification in Systemic Lupus Erythematosus by Impairing Caspase-1 Cleavage of Rab39a., PMID:29866702

P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells., PMID:29291748

Interleukin 6 receptor inhibitor tocilizumab suppresses cytokine expression, inflammasome activation and phagocytosis in a cell model of sepsis., PMID:29441967

Upregulation of NLRP3 inflammasome components in Mooren's ulcer., PMID:27796668

Comparative ontogenetic development of two marine teleosts, gilthead seabream and European sea bass: New insights into nutrition and immunity., PMID:27317010

Fish-oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b(+) macrophages., PMID:27208584

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants., PMID:26555265

Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection., PMID:26032420

Blockade of vascular endothelial growth factor receptor 1 prevents inflammation and vascular leakage in diabetic retinopathy., PMID:25821590

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation., PMID:25744023

Inflammation and pyroptosis mediate muscle expansion in an interleukin-1β (IL-1β)-dependent manner., PMID:25596528

Gilthead seabream (Sparus aurata) immune responses are modulated after feeding with purified antinutrients., PMID:24924098

Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NF-κB signaling., PMID:24706726

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-Mouse CASP1/Caspase-1 Polyclonal Antibody [PMD84101]
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