Catalog No.
PMD51701
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse ENPP1 (Lys617-Asp906).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, E-NPP 1, Lymphocyte antigen 41, Ly-41, Phosphodiesterase I/nucleotide pyrophosphatase 1, Plasma-cell membrane glycoprotein PC-1, Alkaline phosphodiesterase I, 3.1.4.1, Nucleotide pyrophosphatase, NPPase, 3.6.1.9, Nucleotide diphosphatase, Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, Enpp1, Npps, Pc1, Pdnp1
Purification
Purified by antigen affinity column.
Accession
P06802
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Divalent cations stabilize the conformation of plasma cell membrane glycoprotein PC-1 (alkaline phosphodiesterase I)., PMID:7998960
Regulation of purified hepatic PC-1 (phosphodiesterase-I/nucleotide pyrophosphatase) by threonine auto(de)phosphorylation and by binding of acidic fibroblast growth factor., PMID:7532398
Overexpression of membrane glycoprotein PC-1 in MDA-MB231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity., PMID:8923458
Biochemical and molecular identification of distinct forms of alkaline phosphodiesterase I expressed on the apical and basolateral plasma membrane surfaces of rat hepatocytes., PMID:9096610
Chondrocyte-derived apoptotic bodies and calcification of articular cartilage., PMID:9501221
Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit., PMID:10615944
The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3., PMID:11342463
The nucleoside triphosphate pyrophosphohydrolase isozyme PC-1 directly promotes cartilage calcification through chondrocyte apoptosis and increased calcium precipitation by mineralizing vesicles., PMID:11764218
Structural basis of allotypes of ecto-nucleotide pyrophosphatase/phosphodiesterase (plasma cell membrane glycoprotein PC-1) in the mouse and rat, and analysis of allele-specific xenogeneic antibodies., PMID:12121276
Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells., PMID:16087305
Porcine ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1/CD203a): cloning, transcription, expression, mapping, and identification of an NPP1/CD203a epitope for swine workshop cluster 9 (SWC9) monoclonal antibodies., PMID:17064772
Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan., PMID:19107338
The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade., PMID:21195542
A QTL on chromosome 10 modulates cone photoreceptor number in the mouse retina., PMID:21330668
Characterization of monoclonal antibodies to the plasma cell alloantigen ENPP1., PMID:21466281
Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS)., PMID:21738662
Hypophosphatemic rickets., PMID:23108197
Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions., PMID:23169635
Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1., PMID:24997609
Characterization of monoclonal antibodies against porcine pulmonary alveolar macrophages of gnotobiotic miniature swine., PMID:25896759
Decreased expression of ectonucleotidase E-NPP1 in leukocytes from subjects with severe asthma exacerbation., PMID:26405014
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy., PMID:26624227
Wnt activity is associated with cementum-type transition., PMID:27363895
ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells., PMID:29259245
ENPP1-Fc prevents neointima formation in generalized arterial calcification of infancy through the generation of AMP., PMID:30369595
Survival of Long-Lived Plasma Cells (LLPC): Piecing Together the Puzzle., PMID:31130955
Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase., PMID:32028019
Reversion of arterial calcification by elastin-targeted DTPA-HSA nanoparticles., PMID:32151731
Validation of a next-generation sequencing (NGS) panel to improve the diagnosis of X-linked hypophosphataemia (XLH) and other genetic disorders of renal phosphate wasting., PMID:33107440
Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway., PMID:33354501
Development of a High-Throughput Assay to Identify Inhibitors of ENPP1., PMID:33402044
Identification of cell surface targets for CAR-T cell therapies and antibody-drug conjugates in breast cancer., PMID:33838601
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair., PMID:34813507
Strategies for Glycoengineering Therapeutic Proteins., PMID:35494652
The molecular mechanism research of cartilage calcification induced by osteoarthritis., PMID:35611765
An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:36747663
Human antibodies targeting ENPP1 as candidate therapeutics for cancers., PMID:36761762
An atlas of the bone marrow bone proteome in patients with dysproteinemias., PMID:37105956
Discovery of VH domains that allosterically inhibit ENPP1., PMID:37400538
Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma., PMID:37812652
Targeting ENPP1 for cancer immunotherapy: Killing two birds with one stone., PMID:38142838
The use of burosumab to treat autosomal-recessive hypophosphatemic rickets type 2: rationale and a first clinical experience., PMID:38308754
Activation of Nuclear Factor Erythroid 2-Related Factor 2 Transcriptionally Upregulates Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Expression and Inhibits Ectopic Calcification in Mice., PMID:39199142
Regulation of TGF-β1-induced fibroblast differentiation of human periodontal ligament stem cells through the mutually antagonistic action of ectonucleotide pyrophosphatase/phosphodiesterase 1 and 2., PMID:39291269
Discovery of Imidazo[1,2-a]pyrazine Derivatives as Potent ENPP1 Inhibitors., PMID:39357030
A humanized monoclonal antibody targeting an ectonucleotidase rescues cardiac metabolism and heart function after myocardial infarction., PMID:39454569
Use of Whole-Exome Sequencing and Pedigree Analysis to Identify X-linked Hypophosphatemia in Saudi Arabian Families., PMID:39659542
ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells., PMID:39694917
Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy., PMID:39973889
For research use only. Not for human or drug use.
