Catalog No.
PMC45401
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse C4B (Glu988-Thr1317).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Complement C4-B, Complement C4 beta chain, Complement C4 alpha chain, C4a anaphylatoxin, Complement C4 gamma chain, C4b, C4
Purification
Purified by antigen affinity column.
Accession
P01029
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Long-term GABA supplementation mitigates anxiety by modulating complement and neuroinflammatory pathways., PMID:40274802
Pharmacovigilance study and genetic target prediction analysis of FDA adverse event reports (FAERS) for drug-induced sinusitis., PMID:40128146
The role of C4d expression in the diagnosis of bullous pemphigoid: a clinical and histopathological study., PMID:40095080
Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers., PMID:40093011
Association of C4d with disease activity in anti-neutrophil cytoplasmic antibody-associated vasculitis: evidence for classical/lectin complement pathway activation., PMID:40045390
The prognostic relevance of donor-specific antibodies in facial transplantation - A retrospective cohort study., PMID:40043533
Clinical usefulness of E4-phytohemagglutinin reactive C4-binding protein relative front value in serum for distinguishing between ovarian clear cell adenocarcinoma and endometrioma., PMID:40024277
Spatial transcriptomics of Glomerulo-centric antibody mediated rejection in renal transplants., PMID:39993695
Impact of Immunosuppressive Drug Concentrations on Microvascular Inflammation, Negative Donor-Specific Antibodies, and C4d-Negative Status in Kidney Transplant Recipients., PMID:39980440
Association of C4 Null Alleles and Persistently Low C4 in Asian Indian Patients With Systemic Lupus Erythematosus., PMID:39800843
Effectiveness of complement inhibitors against refractory antibody-mediated rejection of lung transplantation: Two clinical cases., PMID:39756547
A Review of the Knops Blood Group System., PMID:39706812
Early and late antibody mediated rejection: Which game is the complement playing?, PMID:39591699
Accurate Visualization of C4d Complement Fragment in Immunohistochemistry by C-Terminal Linear Neoepitope-Specific Antibodies., PMID:39408855
Serotype 15C Streptococcus pneumoniae resistant to classical complement deposition and agglutination by polyclonal rabbit anti-capsular 15B sera., PMID:39368131
Combined proteomics and metabolomics analysis reveal the effect of a training course on the immune function of Chinese elite short-track speed skaters., PMID:39352112
Diagnosis of autoimmune bullous dermatoses: Comparative analysis of immunohistochemical staining using C4d, C3d, IgG, and IgG4 in lesional tissues and perilesional frozen skin samples., PMID:39180885
C4d, rather than C3d and C5b-9, Is Associated with Graft Loss in Recurrent IgA Deposition after Kidney Transplantation., PMID:39154645
Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis., PMID:39125933
The relationship of microvascular inflammation with antibody-mediated rejection in kidney transplantation., PMID:39084463
Utility of C4d Immunohistochemistry in the Diagnosis of Esophageal Pemphigus Vulgaris., PMID:39034277
[Diagnostic significance of C4d in membranous nephropathy]., PMID:38907960
Engineering Agonistic Bispecifics to Investigate the Influence of Distance on Surface-Mediated Complement Activation., PMID:38819221
Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators., PMID:38817607
Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity., PMID:38594415
Back to the future: the uncharted role of T cells in chronic and unexplained microvascular inflammation., PMID:38519233
Elevated expression of complement factor I in lung cancer cells associates with shorter survival-Potentially via non-canonical mechanism., PMID:38395390
Urinary C4d and progression of kidney disease in IgA vasculitis., PMID:38373839
Recurrent IgA Nephropathy or Subclinical Chronic Humoral Rejection With Predominance of Plasma Cells: A Case Report., PMID:38342745
TFPIα anticoagulant function is highly dependent on protein S in vivo., PMID:38306422
Multiomic profiling of transplant glomerulopathy reveals a novel T-cell dominant subclass., PMID:38128610
The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics., PMID:38032300
Myeloperoxidase Staining Identifies Endothelial Injury of Peritubular Capillaries and Glomeruli in Renal Antibody-Mediated Rejection., PMID:37945017
Prospects and Pitfalls of Plasma Complement C4 in Schizophrenia: Building a Better Biomarker., PMID:37734326
Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis., PMID:37426666
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains., PMID:37419978
A conserved 3D pattern in a Streptococcus pyogenes M protein immunogen elicits M-type crossreactivity., PMID:37390991
Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus., PMID:37376642
Systemic evaluation of lymphocyte-bound C4d and immunoglobulins for diagnosis and activity monitoring of systemic lupus erythematosus., PMID:37343744
Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice., PMID:37325666
Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice., PMID:37208602
Morphologic and immunophenotypic evaluation of liver allograft biopsies with contemporaneous serum DSA measurements., PMID:37096730
Histologic and Clinical Outcomes of Patients Developing Post-Liver Transplant Plasma Cell-Rich Rejection., PMID:36883807
Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies., PMID:36171069
SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation., PMID:35860286
Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy., PMID:35740382
Acute Antibody-mediated rejection in liver transplantation: Impact and applicability of the Banff working group on liver allograft pathology 2016 criteria., PMID:35728694
Weak Expression of Terminal Complement in Active Antibody-Mediated Rejection of the Kidney., PMID:35493506
Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S., PMID:35445541
Multifaceted Activities of Seven Nanobodies against Complement C4b., PMID:35428691
For research use only. Not for human or drug use.
