Catalog No.
PMC07201
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse LCAT (Phe25-Glu438).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Phosphatidylcholine-sterol acyltransferase, 2.3.1.43, 1-alkyl-2-acetylglycerophosphocholine esterase, 3.1.1.47, Lecithin-cholesterol acyltransferase, Phospholipid-cholesterol acyltransferase, Platelet-activating factor acetylhydrolase, PAF acetylhydrolase, Lcat
Purification
Purified by antigen affinity column.
Accession
P16301
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A Rare Case of Autoimmune-Mediated Lecithin:Cholesterol Acyltransferase Insufficiency Manifesting as the Acute Onset of Extremely Hypo-High-Density Lipoprotein-Cholesterolemia and Spontaneous Improvement: A Case Report with a Review of the Literature., PMID:39662947
Two Cases of Acquired High-Density Lipoprotein Deficiency with Immunoglobulin G4-Related Lecithin-Cholesterol Acyltransferase Autoantibody., PMID:36384970
ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future., PMID:35524914
Gastric Xanthomatosis Secondary to Lipoprotein X in Primary Biliary Cholangitis., PMID:35403472
Reverse cholesterol transport and hepatic osteodystrophy., PMID:35235770
Novel Insight in Idiopathic Normal Pressure Hydrocephalus (iNPH) Biomarker Discovery in CSF., PMID:34360799
Biological anti-psoriatic therapy profoundly affects high-density lipoprotein function., PMID:33862237
Recombinant human lecithin-cholesterol acyltransferase in patients with atherosclerosis: phase 2a primary results and phase 2b design., PMID:33493256
High-density lipoprotein functionality in systemic lupus erythematosus., PMID:32531506
Generation, expression and utilization of single-domain antibodies for in vivo protein localization and manipulation in sea urchin embryos., PMID:30948018
Immune-mediated acquired lecithin-cholesterol acyltransferase deficiency: A case report and literature review., PMID:29937398
Nephrotic syndrome in infants and children: pathophysiology and management., PMID:28914167
A case of acquired lecithin:cholesterol acyltransferase deficiency with sarcoidosis that remitted spontaneously., PMID:28508975
Antibody Mimetics for the Detection of Small Organic Compounds Using a Quartz Crystal Microbalance., PMID:28192970
Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism., PMID:26644477
The high-resolution crystal structure of human LCAT., PMID:26195816
Higher Cardiovascular Risk in Common Variable Immunodeficiency and X-Linked Agammaglobulinaemia Patients., PMID:26183722
Familial lecithin-cholesterol acyltransferase (LCAT) deficiency; a differential of proteinuria., PMID:25657982
Recombinant human lecithin-cholesterol acyltransferase Fc fusion: analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region., PMID:24115046
Western blots., PMID:23912997
Nephrotic syndrome caused by immune-mediated acquired LCAT deficiency., PMID:23620397
Severe high-density lipoprotein deficiency associated with autoantibodies against lecithin:cholesterol acyltransferase in non-Hodgkin lymphoma., PMID:22271127
An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI., PMID:19847320
Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity., PMID:18363910
[Detection of qualitative abnormalities of HDL by measurement of prebeta1-HDL concentration]., PMID:17265898
Cholesteryl ester transfer protein promotes the formation of cholesterol-rich remnant like lipoprotein particles in human plasma., PMID:16859664
Assignment of the binding site for haptoglobin on apolipoprotein A-I., PMID:15533931
Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats., PMID:12935429
LCAT-dependent conversion of prebeta1-HDL into alpha-migrating HDL is severely delayed in hemodialysis patients., PMID:12595510
[Atherosclerosis and sensitive determination of oxidized LDL using monoclonal antibody]., PMID:12400156
A new enzyme-linked immunosorbent assay with two monoclonal antibodies to specific epitopes measures human lecithin-cholesterol acyltransferase., PMID:11861675
Cyclosporine A transfer between high- and low-density lipoproteins: independent from lipid transfer protein I-facilitated transfer of lipoprotein-coated phospholipids because of high affinity of cyclosporine a for the protein component of lipoproteins., PMID:11745783
Probing the 121-136 domain of lecithin:cholesterol acyltransferase using antibodies., PMID:11368007
Identification of domains in apoA-I susceptible to proteolysis by mast cell chymase. Implications for HDL function., PMID:10828090
Classical LCAT deficiency resulting from a novel homozygous dinucleotide deletion in exon 4 of the human lecithin: cholesterol acyltransferase gene causing a frameshift and stop codon at residue 144., PMID:10487497
Metabolism of oxidized phosphatidylcholines formed in oxidized low density lipoprotein by lecithin-cholesterol acyltransferase., PMID:10393333
Possible induction of renal dysfunction in patients with lecithin:cholesterol acyltransferase deficiency by oxidized phosphatidylcholine in glomeruli., PMID:10073988
Effect of apolipoprotein A-I lipidation on the formation and function of pre-beta and alpha-migrating LpA-I particles., PMID:10026251
Branched synthetic peptide constructs mimic cellular binding and efflux of apolipoprotein AI in reconstituted high density lipoproteins., PMID:9862171
Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I., PMID:9831630
The hydrophobic face orientation of apolipoprotein A-I amphipathic helix domain 143-164 regulates lecithin:cholesterol acyltransferase activation., PMID:9565601
Deletion of amino acids Glu146-->Arg160 in human apolipoprotein A-I (ApoA-ISeattle) alters lecithin:cholesterol acyltransferase activity and recruitment of cell phospholipid., PMID:9538003
In vitro factors affecting the concentration of gamma-LpE (gamma-LpE) in human plasma., PMID:9555949
A natural apolipoprotein A-I variant, apoA-I (L141R)Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta 1-HDL and influences efflux of cholesterol into plasma., PMID:9215551
Cholesteryl ester transfer protein activity enhances plasma cholesteryl ester formation. Studies in CETP transgenic mice and human genetic CETP deficiency., PMID:9194753
Fish-eye disease: structural and in vivo metabolic abnormalities of high-density lipoproteins., PMID:9160810
Alteration in apolipoprotein A-I 22-mer repeat order results in a decrease in lecithin:cholesterol acyltransferase reactivity., PMID:9054424
Characterization of human apolipoprotein A-I expressed in Escherichia coli., PMID:9030191
Localization of apolipoprotein A-I epitopes involved in the activation of lecithin:cholesterol acyltransferase., PMID:9017508
Characterization and potential uses of rabbit polyclonal antibodies against human plasma lecithin-cholesterol acyltransferase., PMID:9181076
For research use only. Not for human or drug use.
