Catalog No.
PMA59901
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse ADAM12 (Thr40-Met408).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, 3.4.24.-, Meltrin-alpha, Adam12, Mltna
Purification
Purified by antigen affinity column.
Accession
Q61824
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
ADAM Proteases in Cancer: Biological Roles, Therapeutic Challenges, and Emerging Opportunities., PMID:40427200
Serum cytokine profiles in children with IgA vasculitis with nephritis., PMID:39235446
ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer., PMID:36545255
Identification of the extracellular metallo-endopeptidases ADAM and ADAMTS in the yellow fever mosquito Aedes aegypti., PMID:35932972
Gold Nanostars Combined with the Searched Antibody for Targeted Oral Squamous Cell Carcinoma Therapy., PMID:35603744
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation., PMID:32572163
Role of hypoxia-related proteins in adenoid cystic carcinoma invasion., PMID:32386517
Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia., PMID:28637396
Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo., PMID:28425175
Expression of CDCP1 and ADAM12 in the ovarian cancer microenvironment., PMID:27685922
Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, hypoxia-inducible factor 1α, a disintegrin and metalloproteinase 12, and heparin-binding epidermal growth factor., PMID:26707922
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain., PMID:26477568
Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts., PMID:24850908
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth., PMID:24006261
ADAM12-cleaved ephrin-A1 contributes to lung metastasis., PMID:23686306
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis., PMID:23578941
Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model., PMID:22960610
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion., PMID:21986939
Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development., PMID:21786032
Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity., PMID:20951132
Molecules and signaling pathways involved in the expression of OC-STAMP during osteoclastogenesis., PMID:20882308
Alpha9beta1 integrin in melanoma cells can signal different adhesion states for migration and anchorage., PMID:19796635
Potential markers of preeclampsia--a review., PMID:19602262
Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism., PMID:19394555
The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis., PMID:19040574
Suppression of proHB-EGF carboxy-terminal fragment nuclear translocation: a new molecular target therapy for gastric cancer., PMID:18559618
Urinary metalloproteinases: noninvasive biomarkers for breast cancer risk assessment., PMID:18483323
ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage., PMID:18311789
Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein., PMID:18241035
The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor., PMID:17620406
Integrin alpha3 subunit participates in myoblast adhesion and fusion in vitro., PMID:16533309
Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia., PMID:15994630
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer., PMID:15586220
ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation., PMID:15574885
Increased expression of ADAM family members in human breast cancer and breast cancer cell lines., PMID:15565459
Isolation and embryonic expression of avian ADAM 12 and ADAM 19., PMID:15533821
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage., PMID:15381692
The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells., PMID:15300588
Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin alpha7beta1., PMID:15242759
ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function., PMID:12915587
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA., PMID:12509413
[The role of HB-EGF in angiotensin II--signaling]., PMID:12397684
Metalloprotease-disintegrin ADAM 12 interacts with alpha-actinin-1., PMID:11439084
Analysis for transcript expression of meltrin alpha in normal, regenerating, and denervated rat muscle., PMID:11129438
Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src., PMID:11127814
RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction., PMID:10944520
ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3., PMID:10849447
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading., PMID:10831617
For research use only. Not for human or drug use.
