Catalog No.
PMA55401
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse FLIP/CFLAR (Lys251-Thr481).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
CASP8 and FADD-like apoptosis regulator, Caspase homolog, CASH, Caspase-eight-related protein, Casper, Caspase-like apoptosis regulatory protein, CLARP, Cellular FLICE-like inhibitory protein, c-FLIP, FADD-like antiapoptotic molecule 1, FLAME-1, Inhibitor of FLICE, I-FLICE, MACH-related inducer of toxicity, MRIT, Usurpin, CASP8 and FADD-like apoptosis regulator subunit p43, CASP8 and FADD-like apoptosis regulator subunit p12, Cflar, Cash
Purification
Purified by antigen affinity column.
Accession
O35732
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway., PMID:39736469
Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate., PMID:39547906
Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease., PMID:39535744
A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants., PMID:39243752
The role of DNA in the pathogenesis of SLE: DNA as a molecular chameleon., PMID:38749573
FLip mutations (L455F + F456L) in newly emerging VOI, JN.1: Its antibody and immune escape., PMID:38677090
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection., PMID:38627386
Molecular mechanisms of Na+-driven bile acid transport in human NTCP., PMID:38544409
The Thyroid Swing: A Patient's Journey From Hypothyroidism to Hyperthyroidism., PMID:38374853
Immune evasion, infectivity, and fusogenicity of SARS-CoV-2 BA.2.86 and FLip variants., PMID:38194968
AlphaFold2-Enabled Atomistic Modeling of Epistatic Binding Mechanisms for the SARS-CoV-2 Spike Omicron XBB.1.5, EG.5 and FLip Variants: Convergent Evolution Hotspots Cooperate to Control Stability and Conformational Adaptability in Balancing ACE2 Binding and Antibody Resistance., PMID:38168257
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer., PMID:38037106
Enhanced neutralization of SARS-CoV-2 variant BA.2.86 and XBB sub-lineages by a tetravalent COVID-19 vaccine booster., PMID:38029742
Immune Evasion, Infectivity, and Fusogenicity of SARS-CoV-2 Omicron BA.2.86 and FLip Variants., PMID:37745517
Paradoxical psoriasis: The flip side of idiopathic psoriasis or an autocephalous reversible drug reaction?, PMID:37731549
Drastic alterations in the loop structure around colchicine upon complex formation with an engineered lipocalin indicate a conformational selection mechanism., PMID:37584182
Evaluating orthogonality between ion-pair reversed phase, anion exchange, and hydrophilic interaction liquid chromatography for the separation of synthetic oligonucleotides., PMID:37419013
[Autoimmune polyglandular syndrome type 3 diagnosed with cerebral venous sinus thrombosis: a case report]., PMID:37100622
SALVO: Single-Arm Trial of Ipilimumab and Nivolumab as Adjuvant Therapy for Resected Mucosal Melanoma., PMID:37000165
Evaluation of cellular water exchange in a mouse glioma model using dynamic contrast-enhanced MRI with two flip angles., PMID:36810898
Reversing "Flip-Flop" Phenomenon of 131 I and Glucose Avidity in RET-Fusion Positive Radioiodine-Refractory Thyroid Cancer Lesions After Treatment of Pralsetinib., PMID:36327463
Inter-Leaflet Phospholipid Exchange Impacts the Ligand Density Available for Protein Binding at Supported Lipid Bilayers., PMID:35617691
FibroScan-AST (FAST) Score for Nonalcoholic Steatohepatitis - Validation in an Indian Cohort., PMID:35535068
Dipolar Order Parameters in Large Systems With Fast Spinning., PMID:34957221
High-Throughput Selection and Characterisation of Aptamers on Optical Next-Generation Sequencers., PMID:34502110
Single versus multiple doses of Tocilizumab in critically ill patients with coronavirus disease 2019 (COVID-19): A two-center, retrospective cohort study., PMID:34438133
Combining Bevacizumab with Knocked-Down β-Catenin Reduces VEGF-A and Slug mRNA in HepG2 but not in Caco-2 Cell Lines., PMID:34429048
IL13Rα2‑ and EGFR‑targeted pseudomonas exotoxin potentiates the TRAIL‑mediated death of GBM cells., PMID:34080646
G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181., PMID:33352782
Hypo-Expression of Flice-Inhibitory Protein and Activation of the Caspase-8 Apoptotic Pathways in the Death-Inducing Signaling Complex Due to Ischemia Induced by the Compression of the Asphyxiogenic Tool on the Skin in Hanging Cases., PMID:33198065
Overexpression of miR-382 Sensitizes Hepatocellular Carcinoma Cells to γδ T Cells by Inhibiting the Expression of c-FLIP., PMID:32953981
Platelet immunophenotyping in health and inherited bleeding disorders, a review and practical hints., PMID:32516490
DR5-targeted, chemotherapeutic drug-loaded nanoparticles induce apoptosis and tumor regression in pancreatic cancer in vivo models., PMID:32504778
Downregulation of c‑FLIP and upregulation of DR‑5 by cantharidin sensitizes TRAIL‑mediated apoptosis in prostate cancer cells via autophagy flux., PMID:32319535
PI3K/AKT inhibitors aggravate death receptor-mediated hepatocyte apoptosis and liver injury., PMID:31445927
ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells., PMID:31443721
Symmetry-based ligand design and evaluation of small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 interaction., PMID:31351692
FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling., PMID:30766540
Residual Seal Force Testing: A Suitable Method for Seal Quality Determination of (High Potent) Parenterals., PMID:30361287
Hepatitis B Spliced Protein (HBSP) Suppresses Fas-Mediated Hepatocyte Apoptosis via Activation of PI3K/Akt Signaling., PMID:30209179
Hepatitis B Virus Surface Antigen Enhances the Sensitivity of Hepatocytes to Fas-Mediated Apoptosis via Suppression of AKT Phosphorylation., PMID:30171166
Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy., PMID:30088816
Magnetic nanoparticle-mediated gene therapy to induce Fas apoptosis pathway in breast cancer., PMID:29593359
Treatment of Donor Rat Hearts Prior to Transplantation with FLIP (FADD-Like Interleukin Beta-Converting Enzyme (FLICE)-Like Inhibitory Protein) in Cardioplegic Solution Decreased Apoptosis at Thirty Minutes Post-transplantation and Decreased Total Tyrosine Phosphorylation Levels., PMID:29483486
Differential equation methods for simulation of GFP kinetics in non-steady state experiments., PMID:29367436
Significance of Immune-related Lipase Increase Induced by Antiprogrammed Death-1 or Death Ligand-1 Antibodies: A Brief Communication., PMID:29252914
Cost-utility analysis of Palivizumab for Respiratory Syncytial Virus infection prophylaxis in preterm infants: update based on the clinical evidence in Spain., PMID:29041909
Immunohistochemical Analysis of the Extrinsic Apoptosis Process in the Non-Neoplastic and Neoplastic Prostate., PMID:28984341
The proteasome deubiquitinase inhibitor b-AP15 enhances DR5 activation-induced apoptosis through stabilizing DR5., PMID:28808321
Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2., PMID:28512091
For research use only. Not for human or drug use.
