Catalog No.
PHN53001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human IKZF3 (Glu84-Thr326).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Zinc finger protein Aiolos, Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3
Purification
Purified by antigen affinity column.
Accession
Q9UKT9
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Sequence variants influencing the regulation of serum IgG subclass levels., PMID:39277589
Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development., PMID:39179932
Targeting Ikaros and Aiolos: reviewing novel protein degraders for the treatment of multiple myeloma, with a focus on iberdomide and mezigdomide., PMID:39054911
Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens., PMID:37945755
IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target., PMID:36180600
Drug resistance and minimal residual disease in multiple myeloma., PMID:35582527
Comprehensive Analysis of lncRNA Expression Profile and the Potential Role of ENST00000604491 in Graves' Disease., PMID:35509980
Pyrotinib combined with thalidomide in advanced non-small-cell lung cancer patients harboring HER2 exon 20 insertions (PRIDE): protocol of an open-label, single-arm phase II trial., PMID:34530760
Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus., PMID:33727237
A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation., PMID:33689703
Urinary Cell Transcriptome Profiling and Identification of ITM2A, SLAMF6, and IKZF3 as Biomarkers of Acute Rejection in Human Kidney Allografts., PMID:32766436
Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide., PMID:32591583
Rapid and deep-scale ubiquitylation profiling for biology and translational research., PMID:31953384
Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells., PMID:31558544
Immunomodulatory drugs in the treatment of multiple myeloma., PMID:31187860
IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos., PMID:30228232
Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus., PMID:29945920
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles., PMID:29343548
Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity., PMID:28848067
Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups., PMID:28584254
Genetic variants associated with rheumatoid arthritis patients and serotypes in European populations., PMID:26939566
Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells., PMID:26823144
PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development., PMID:23463102
Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation., PMID:23303821
Lacking of Aiolos accelerates pre-mature B cell apoptosis mediated by BCR signaling through elevation in cytochrome c release., PMID:19427336
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche., PMID:19228948
Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1., PMID:18974788
Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development., PMID:17971486
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits., PMID:17363301
Pax5--a critical inhibitor of plasma cell fate., PMID:16918686
Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity., PMID:14718515
Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice., PMID:12574333
The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21., PMID:11371362
Aiolos regulates B cell activation and maturation to effector state., PMID:9806640
Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors., PMID:9560339
For research use only. Not for human or drug use.
