Catalog No.
PHE35401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human MTOR (Ser27-Gln291).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Serine/threonine-protein kinase mTOR, 2.7.11.1, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Purification
Purified by antigen affinity column.
Accession
P42345
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution., PMID:40489625
MBD2 promotes B cell differentiation and BCR signaling in systemic lupus erythematosus by regulating the LEF-1-PTEN-PI3K axis., PMID:40467564
Development and application of a targeted phosphoproteomics method for analysing the mTOR pathway dynamics in zebrafish PAC2 cell line., PMID:40466985
Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future., PMID:40463417
Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes., PMID:40447640
Comprehensive advances in HER2-positive and HER2-negative breast cancer: unveiling molecular mechanisms and exploring cutting-edge targeted therapies for enhanced patient outcomes., PMID:40439885
Hedgehog inhibitors exert anti-proliferation effects and synergistically interact with trastuzumab in HER2-positive gastric cancer models., PMID:40426308
Patient preferences for treatments in hormone receptor-positive/HER2-negative metastatic breast cancer in Italy: a discrete choice experiment study., PMID:40405072
Autophagy inhibition amplifies anti-tumor immunity effect of dinutuximab beta on neuroblastoma via the VEGFR/AKT/mTOR and ROS/NF-κB pathways., PMID:40378433
[Results of kidney transplantation in patients with end-stage renal disease caused by glomerulonephritis]., PMID:40377558
TSAb inhibits osteogenic differentiation of MC3T3-E1 cells and exacerbates bone loss in Graves' disease mice., PMID:40354515
Extensive genotype-phenotype heterogeneity in renal cell carcinoma - a proof-of-concept study., PMID:40352587
Cystatin antibodies interfere with ovary development in Haemaphysalis doenitzi (Acari: Ixodidae)., PMID:40333887
Relationship between autoimmunity and COPD: an investigation based on proteomic profiling and antinuclear antibody screening., PMID:40329569
LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications., PMID:40328979
BAFF modulates T follicular helper cell differentiation through the BAFFR-PI3K/AKT-mTOR signaling pathway in bullous pemphigoid., PMID:40328590
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis., PMID:40327404
Enhanced cytotoxicity of T-DM1 in HER2-low carcinomas via autophagy inhibition., PMID:40315224
[Mechanism of 2,6-DMBQ attenuates airway inflammatory responses in asthmatic mice via the mTOR signaling pathway]., PMID:40241367
Multiplexed imaging mass cytometry elicits p-S6 as a therapeutic and prognostic factor in diffuse large B-cell lymphoma., PMID:40238894
Valproic acid promotes transcriptional activation of Drd2 by mediating histone acetylation to inhibit the mTOR-Pttg1 signaling axis and exerts anti-PitNETs activity., PMID:40220407
Synergistic activity of tafasitamab and metronomic chemotherapy on diffuse large B-cell lymphoma through inhibition of the AKT/mTOR signaling pathway., PMID:40175588
Integrative analysis of a novel signature incorporating metabolism and stemness-related genes for risk stratification and assessing clinical outcomes and therapeutic responses in lung adenocarcinoma., PMID:40170009
CRISPR screens with trastuzumab emtansine in HER2-positive breast cancer cell lines reveal new insights into drug resistance., PMID:40165206
Novel Estrogen Receptor - Targeted Therapies in Hormone-Receptor Positive Breast Cancer., PMID:40163189
The role of the mTOR pathway in breast cancer stem cells (BCSCs): mechanisms and therapeutic potentials., PMID:40158191
Activation of the Mammalian Target of Rapamycin Pathway in Endothelial Cells in Antiphospholipid Antibody-Positive Patients with Leg Ulcers., PMID:40141392
Lupenone preserves T cell activity by recovery of CD40L expression and protection from cytotoxicity due to methamphetamine exposure., PMID:40111983
Targeting autophagy in autoimmune glomerular diseases., PMID:40106213
Safety of Everolimus in Lung Transplant Recipients Undergoing Surveillance Bronchoscopy with Transbronchial Forceps Biopsy and Cryobiopsy: A Retrospective Cohort Study., PMID:40094256
ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development., PMID:40090133
BRD7 Inhibited Immune Escape in Nasopharyngeal Carcinoma via Inhibiting PD-L1 Expression., PMID:40083706
Antibody-Based and Other Novel Agents in Adult B-Cell Acute Lymphoblastic Leukemia., PMID:40075627
[Early conversion to belatacept post-transplantation: state of the art and expert opinion]., PMID:40066607
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364
Clinical Outcomes and Treatment Strategies of Adult Transplant-Associated Thrombotic Microangiopathy: External Validation of Harmonizing Definitions and High-Risk Criteria., PMID:40047384
Stabilisation of extracellular matrix is crucial to rapamycin-mediated life span increase in Marfan mgR/mgR mice., PMID:40021021
A novel and promising therapeutic approach for treating pancreatic cancer: Nectin‑4‑targeted antibody‑drug conjugates alone or combined with autophagy inhibitors., PMID:40017149
Triple-Negative Breast Cancer Systemic Treatment: Disruptive Early-Stage Developments for Overcoming Stagnation in the Advanced Pipeline., PMID:40002228
Updates in Head and Neck Oncology - Current Knowledge and Future Horizons., PMID:39974445
NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model., PMID:39932765
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway., PMID:39923560
Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2-Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation., PMID:39917999
Signaling Activation and Modulation in Extrafollicular B Cell Responses., PMID:39917832
Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma., PMID:39912261
ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI., PMID:39903532
Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma., PMID:39875173
Dual neutralization of TGF-β and IL-21 regulates Th17/Treg balance by suppressing inflammatory signalling in the splenic lymphocytes of Staphylococcus aureus infection-induced septic arthritic mice., PMID:39831928
Antiphospholipid antibodies positivity as a potential risk factor for restenosis following arteriovenous fistula stenting in hemodialysis patients: a pilot study., PMID:39830377
Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research., PMID:39804528
For research use only. Not for human or drug use.
