Catalog No.
PHD23201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PRKCA (Asn30-Gly311).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Protein kinase C alpha type, PKC-A, PKC-alpha, 2.7.11.13, PRKCA, PKCA, PRKACA
Purification
Purified by antigen affinity column.
Accession
P17252
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study., PMID:38757252
Prognostic value of ALK overexpression and molecular abnormalities in high-grade serous ovarian carcinoma., PMID:37522200
Association Between Plasma Rituximab Concentration and the Risk of Major Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitides During Rituximab Maintenance Therapy., PMID:37134130
The WHO 2018 Classification of Cutaneous Melanocytic Neoplasms: Suggestions From Routine Practice., PMID:34277420
New insights into the pathophysiology and clinical care of rare primary liver cancers., PMID:33205035
SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1., PMID:30711516
Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion., PMID:30622337
Chemokine CC-motif ligand 2 participates in platelet function and arterial thrombosis by regulating PKCα-P38MAPK-HSP27 pathway., PMID:29864522
Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction., PMID:29731111
PKCα diffusion and translocation are independent of an intact cytoskeleton., PMID:28352102
FGFR1 and FGFR2 in fibrolamellar carcinoma., PMID:26259677
CD99 inhibits CD98-mediated β1 integrin signaling through SHP2-mediated FAK dephosphorylation., PMID:26172215
Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKCα Activity under Mechanical Stimulation on the Elastomeric Substrates., PMID:26160374
A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome., PMID:25982116
Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer., PMID:25752336
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network., PMID:25241761
Intracellular TCR-signaling pathway: novel markers for lymphoma diagnosis and potential therapeutic targets., PMID:25118816
Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCα and FAK/Fyn in promoting mesenchymal stem cell motility., PMID:24738865
PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells., PMID:24447339
TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCα and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620., PMID:23616010
PKCα is involved in the progression of kidney carcinoma through regulating netrin-1/UNC5B signaling pathway., PMID:23526078
Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium., PMID:21454537
PKCalpha expression is a marker for breast cancer aggressiveness., PMID:20398285
PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1., PMID:20011080
Effects of Lewis Y antigen on the gene expression of multiple drug resistance-associated proteins in human ovarian cancer RMG-I-H cells., PMID:19771531
Sequential activation of protein kinase C isoforms by organic dust is mediated by tumor necrosis factor., PMID:19635931
Membrane ERalpha-dependent activation of PKCalpha in endometrial cancer cells by estradiol., PMID:18534651
Impaired gap junction formation and intercellular calcium signaling in urinary bladder cancer cells can be improved by Gö6976., PMID:17957529
Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo., PMID:17016558
Abnormal group I metabotropic glutamate receptor expression and signaling in the frontal cortex in Pick disease., PMID:16042316
Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization., PMID:15367584
The transcription factor Bhlhb4 is required for rod bipolar cell maturation., PMID:15363390
Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110., PMID:15314167
Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses., PMID:15199098
Antisense approaches in prostate cancer., PMID:15174974
Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma., PMID:15173074
Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases., PMID:15169840
Inhibition of Fas-mediated apoptotic cell death of murine T lymphocytes in a mouse model of immunosenescence in linkage to deterioration in cell membrane raft function., PMID:15096185
Proliferation of human melanoma cells is under tight control of protein kinase C alpha., PMID:15095285
Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells., PMID:15016832
Hog barn dust extract augments lymphocyte adhesion to human airway epithelial cells., PMID:14729721
Direct association and translocation of PKC-alpha with calponin., PMID:14726309
Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization., PMID:14657242
Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression., PMID:14645153
Escherichia coli K1 invasion increases human brain microvascular endothelial cell monolayer permeability by disassembling vascular-endothelial cadherins at tight junctions., PMID:14593586
cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes., PMID:14527960
Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism., PMID:12970360
Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation., PMID:12920028
Protein kinase Cbeta1, a major regulator of TCR-CD28-activated signal transduction leading to IL-2 gene transcription and secretion., PMID:12917261
Overexpression of skin protein kinase C-alpha in anagen hair follicles during induced growth of mouse hair., PMID:12823308
For research use only. Not for human or drug use.
