Anti-Human NFATC1 Polyclonal Antibody

Catalog No.

PHB70801

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human NFATC1 (Ser423-Ile700).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc, NFATC1, NFAT2, NFATC

Purification

Purified by antigen affinity column.

Accession

O95644

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis., PMID:40057805

CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory arthritis., PMID:39955597

Duvelisib is a novel NFAT inhibitor that mitigates adalimumab-induced immunogenicity., PMID:39850568

Molecular Mechanisms of Curdlan-Induced Suppression of NFATc1 Expression in Osteoclasts., PMID:39606840

Multi-omics profiling of retinal pigment epithelium reveals enhancer-driven activation of RANK-NFATc1 signaling in traumatic proliferative vitreoretinopathy., PMID:39183203

NFATc1 Is Required for Vitamin D- and Phosphate-Mediated Regulation of Osteocyte Lacuno-Canalicular Remodeling., PMID:39024412

DLK1 regulates periodontal inflammation by inhibiting NF-κB p65 and JNK signaling pathways., PMID:38995322

Qingfei mixture mitigates immunosuppression of tumor microenvironment in non-small cell lung cancer by blocking stat1/Ido1-mediated tryptophan-kynurenine pathway., PMID:38882349

Histological and immunohistochemical analyses of osteoclast maturation in giant cell tumor of bone., PMID:38244437

Biallelic NFATC1 mutations cause an inborn error of immunity with impaired CD8+ T-cell function and perturbed glycolysis., PMID:37249233

Severe asthma ILC2s demonstrate enhanced proliferation that is modified by biologics., PMID:37114915

Dual Role of Interleukin-20 in Different Stages of Osteoclast Differentiation and Its Osteoimmune Regulation during Alveolar Bone Remodeling., PMID:36835229

Regulation of B cell receptor signalling by Epstein-Barr virus nuclear antigens., PMID:36383217

Antagonism of m3 Alleviates Type 2 Inflammation in Allergic Rhinitis Mice., PMID:36343939

The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis., PMID:36003376

Exploring the mechanism of berberine-mediated Tfh cell immunosuppression., PMID:35901597

B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells., PMID:35778390

Notch2 Blockade Mitigates Methotrexate Chemotherapy-Induced Bone Loss and Marrow Adiposity., PMID:35563828

NFATc1/αA and Blimp-1 Support the Follicular and Effector Phenotype of Tregs., PMID:35069572

Gegen Qinlian Decoction ameliorates type 2 diabetes osteoporosis via IGFBP3/MAPK/NFATc1 signaling pathway based on cytokine antibody array., PMID:34798519

RANK- NFATc1 signaling forms positive feedback loop on rank gene expression via functional NFATc1 responsive element in rank gene promoter., PMID:34358968

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation., PMID:34216837

NFATc1 is Suppressed in Tumor Microenvironment of Hodgkin Lymphoma., PMID:34181355

ZhiJingSan Inhibits Osteoclastogenesis via Regulating RANKL/NF-κB Signaling Pathway and Ameliorates Bone Erosion in Collagen-Induced Mouse Arthritis., PMID:34122118

The Optimal Dose of Tacrolimus in Combination Therapy with an Anti-TNFα Antibody in a Mouse Colitis Model., PMID:33790106

A novel modified RANKL variant can prevent osteoporosis by acting as a vaccine and an inhibitor., PMID:33784004

The Role of Siglec-G on Immune Cells in Sepsis., PMID:33708213

IgG Immunocomplexes Drive the Differentiation of a Novel Subset of Osteoclasts Independent of RANKL and Inflammatory Cytokines., PMID:33651383

A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis., PMID:33441995

Hispolon inhibits RANKL induced osteoclast differentiation in vitro., PMID:33428992

Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis., PMID:33314777

Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia., PMID:33206936

Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes., PMID:33148174

Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia., PMID:32983140

Inhibition of the activation of γδT17 cells through PPARγ-PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid., PMID:32929062

TLR-MyD88 signaling blockades inhibit refractory B-1b cell immune responses to transplant-related glycan antigens., PMID:32865877

Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis., PMID:32759820

Methionine Enkephalin Suppresses Osteocyte Apoptosis Induced by Compressive Force through Regulation of Nuclear Translocation of NFATc1., PMID:32666020

Dendritic cells-derived interferon-λ1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis., PMID:32488049

HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment., PMID:32365752

Zoledronate Inhibits Osteoclast Differentiation via Suppressing Vascular Endothelial Growth Factor Receptor 2 Expression., PMID:32274606

Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis., PMID:32256192

Phytoestrogens protect joints in collagen induced arthritis by increasing IgG glycosylation and reducing osteoclast activation., PMID:32172207

Estrogen Receptor, Inflammatory, and FOXO Transcription Factors Regulate Expression of Myasthenia Gravis-Associated Circulating microRNAs., PMID:32153563

Genetic loss of NFAT2 (NFATc1) impairs B cell development of B1 and B2 B cells., PMID:32014271

A Novel, Tumor-Induced Osteoclastogenesis Pathway Insensitive to Denosumab but Interfered by Cannabidiol., PMID:31835378

IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2., PMID:31713625

Osteoclastogenesis inhibition by mutated IGSF23 results in human osteopetrosis., PMID:31560140

Glycolaldehyde-modified advanced glycation end-products inhibit differentiation of human monocytes into osteoclasts via upregulation of IL-10., PMID:31421252

Multitarget-based cotreatment with cilostazol and celecoxib synergistically suppresses collagen-induced arthritis in mice by enhancing interleukin-10 expression., PMID:31170675

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