Catalog No.
PHB02901
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SH2D1A (Asp2-Pro97).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP
Purification
Purified by antigen affinity column.
Accession
O60880
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Genome and transcriptome sequencing for inborn errors of immunity: a feasible multi-omics diagnostic approach., PMID:40226629
From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia., PMID:39836844
Case report: EBV-related eye orbits and sinuses lymphohistiocytic infiltration responsive to rituximab in a patient with X lymphoproliferative syndrome type 1., PMID:38633254
Association of SH2 domain-containing protein 1A, immunoglobulins and T lymphocyte subsets with Epstein- Barr virus infections., PMID:37661675
Plasma proteomic profiling reveals KRT19 could be a potential biomarker in patients with anti-MDA5+ dermatomyositis., PMID:37160775
The transcription factor Mef2d regulates B:T synapse-dependent GC-TFH differentiation and IL-21-mediated humoral immunity., PMID:36961907
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders., PMID:36209991
Allosteric inhibition of SHP2 rescues functional T-cell abnormalities in SAP deficiency., PMID:35839843
Fatal X-linked lymphoproliferative disease type 1-associated limbic encephalitis with positive anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody., PMID:35778314
Case Report: Meningoencephalitis With Thrombotic Occlusive Vasculopathy in a Young EBV-Naïve Boy Is Associated With a Novel SH2D1A Mutation., PMID:34987501
Primary Immune Regulatory Disorders With an Autoimmune Lymphoproliferative Syndrome-Like Phenotype: Immunologic Evaluation, Early Diagnosis and Management., PMID:34447369
Detailed Phenotypic and Functional Characterization of a Rare, Antibody-Dependent SLAM-Associated Protein Expression Pattern., PMID:32276922
Progression of AITL-like tumors in mice is driven by Tfh signature proteins and T-B cross talk., PMID:32130407
Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection., PMID:30740108
Germinal Center Alloantibody Responses Mediate Progression of Chronic Allograft Injury., PMID:30728823
Transfer of gene-corrected T cells corrects humoral and cytotoxic defects in patients with X-linked lymphoproliferative disease., PMID:29705247
Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells., PMID:29133396
A Rapid Blood Test To Determine the Active Status and Duration of Acute Viral Infection., PMID:28918638
2B4-SAP signaling is required for the priming of naive CD8+ T cells by antigen-expressing B cells and B lymphoma cells., PMID:28344876
Novel Mutations in SH2D1A Gene in X-linked Lymphoproliferative Syndrome, Diagnosed After B-Cell Non-Hodgkin Lymphoma., PMID:28267077
Variable clinical phenotypes of X-linked lymphoproliferative syndrome in China: Report of five cases with three novel mutations and review of the literature., PMID:27288720
Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production., PMID:27183584
High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells., PMID:26785729
SLAM family receptors in normal immunity and immune pathologies., PMID:26682762
The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice., PMID:26501485
Cerebral Vasculitis in X-linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant., PMID:26433589
Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection., PMID:26150504
Epstein-Barr virus candidate genes and multiple sclerosis., PMID:25787055
Role of the 2B4 Receptor in CD8+ T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components., PMID:25722295
A possible familial lymphoproliferative disorder in two male siblings of children with recurrent wheezing and lung infections since infancy., PMID:24934116
Reduced-intensity conditioning hematopoietic cell transplantation is an effective treatment for patients with SLAM-associated protein deficiency/X-linked lymphoproliferative disease type 1., PMID:24923536
XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells., PMID:24496997
Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice., PMID:24379120
Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance., PMID:24373350
Immunologic difference between hypersensitivity to mosquito bite and hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection., PMID:24204658
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis., PMID:24045941
X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis., PMID:23973892
Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination., PMID:23743125
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity., PMID:23319045
Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia., PMID:23280491
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses., PMID:22613797
From SAP-less T cells to helpless B cells and back: dynamic T-B cell interactions underlie germinal center development and function., PMID:22500829
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence., PMID:22438812
Slam-associated protein plays a key role in development of autoimmunity., PMID:22349617
SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling., PMID:22048771
CD4+ T Lymphocytes with follicular helper phenotype (T(FH)) in patients with SH2D1A deficiency (XLP)., PMID:21996454
X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis., PMID:21541208
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses., PMID:21445533
The role of SAP and SLAM family molecules in the humoral immune response., PMID:21091715
For research use only. Not for human or drug use.
