Catalog No.
PHA48601
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human PPM1D (Ser96-Leu395).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Protein phosphatase 1D, 3.1.3.16, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1
Purification
Purified by antigen affinity column.
Accession
O15297
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer., PMID:30413718
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells., PMID:26284262
Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?, PMID:25599124
Overexpression of wip1 is associated with biologic behavior in human clear cell renal cell carcinoma., PMID:25334029
Phosphatase Wip1 is essential for the maturation and homeostasis of medullary thymic epithelial cells in mice., PMID:23966632
Genetic variants and mutations of PPM1D control the response to DNA damage., PMID:23907125
The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation., PMID:23690919
Nutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrol., PMID:23666059
Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage., PMID:23405243
Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis., PMID:23255129
WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma., PMID:22037313
Phosphatase assay for multi-phosphorylated substrates using phosphatase specific-motif antibody., PMID:21558087
UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells., PMID:20947453
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response., PMID:20460517
The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression., PMID:19435816
Frequent amplification and overexpression of CCND1 in male breast cancer., PMID:15300811
For research use only. Not for human or drug use.
