Catalog No.
PHA24001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human UTY (Lys1042-Trp1205).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Histone demethylase UTY, 1.14.11.68, Ubiquitously-transcribed TPR protein on the Y chromosome, Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein, [histone H3]-trimethyl-L-lysine(27) demethylase UTY, UTY, KDM6C
Purification
Purified by antigen affinity column.
Accession
O14607
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure., PMID:39183958
Circulating macrophages as the mechanistic link between mosaic loss of Y-chromosome and cardiac disease., PMID:37488646
Sex chromosome DSD individuals with mosaic 45,X0 and aberrant Y chromosomes in 46,XY cells: distinct gender phenotypes and germ cell tumour risks§., PMID:35481403
AZFa candidate gene UTY and its X homologue UTX are expressed in human germ cells., PMID:35128450
Functional study of 14-3-3 protein epsilon (YWHAE) in keratinocytes: microarray integrating bioinformatics approaches., PMID:31244373
Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance., PMID:24161680
H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associated with low male : female ratio in subsequent live births., PMID:20823116
Immunotherapy with antibody-targeted HLA class I complexes: results of in vivo tumour cell killing and therapeutic vaccination., PMID:17709989
Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission., PMID:15613541
HY peptides modulate transplantation responses to skin allografts., PMID:12407024
Minor histocompatibility antigens., PMID:9368774
For research use only. Not for human or drug use.
