Catalog No.
PWN53601
Species reactivity
Agkistrodon contortrix contortrix (Southern copperhead)
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Snake SVMP/Alfimeprase (Phe4-Pro203).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Snake venom metalloproteinase fibrolase, SVMP, 3.4.24.72, Fibrinolytic metalloproteinase, Fibrinolytic proteinase, Alfimeprase
Purification
Purified by antigen affinity column.
Accession
P28891
Applications
ELISA, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Comparative in vitro immunoreactivity and protein analysis of Trimeresurus albolabris and Tropidolaemus wagleri venoms., PMID:40221593
First Look at the Venoms of Two Sinomicrurus Snakes: Differences in Yield, Proteomic Profiles, and Immunorecognition by Commercial Antivenoms., PMID:39852972
Deciphering toxico-proteomics of Asiatic medically significant venomous snake species: A systematic review and interactive data dashboard., PMID:39393539
Identification of antigenic proteins from the venom of Malaysian snakes using immunoprecipitation assay and tandem mass spectrometry (LC-MS/MS)., PMID:39286227
Importance of the Cysteine-Rich Domain of Snake Venom Prothrombin Activators: Insights Gained from Synthetic Neutralizing Antibodies., PMID:39195771
A comparison of the venom proteomes and potential therapeutics of 3 African naja subgenera., PMID:38838860
Doxycycline-Mediated Inhibition of Snake Venom Phospholipase and Metalloproteinase., PMID:38748405
Immunochemical Recognition of Bothrops rhombeatus Venom by Two Polyvalent Antivenoms., PMID:38535818
Comparative analysis of Deinagkistrodon acutus venom from Taiwan and China utilizing chromatographic, electrophoretic, and bioinformatic approaches, along with ELISA employing a monospecific antivenom., PMID:38423218
Evaluation of venom diversity and antivenom quality from the venom of long-term captive vs recently wild captured Pseudocerastes persicus snake: An In vitro and In vivo study., PMID:38417708
Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom-induced toxicities., PMID:37558138
Bothrops atrox venom: Biochemical properties and cellular phenotypes of three highly toxic classes of toxins., PMID:37442518
Inhibitory Effects of Varespladib, CP471474, and Their Potential Synergistic Activity on Bothrops asper and Crotalus durissus cumanensis Venoms., PMID:36500682
A current perspective on snake venom composition and constituent protein families., PMID:36437303
A Combined Bioassay and Nanofractionation Approach to Investigate the Anticoagulant Toxins of Mamba and Cobra Venoms and Their Inhibition by Varespladib., PMID:36355986
Venom Variation of Neonate and Adult Chinese Cobras in Captivity Concerning Their Foraging Strategies., PMID:36136536
Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing., PMID:36108067
Biochemistry and toxicology of proteins and peptides purified from the venom of Vipera berus berus., PMID:35769869
Biological and proteomic characterization of the venom from Peruvian Andes rattlesnake Crotalus durissus., PMID:34968566
Development of Antibody Detection ELISA Based on Immunoreactive Toxins and Toxin-Derived Peptides to Evaluate the Neutralization Potency of Equine Plasma against Naja atra in Taiwan., PMID:34822602
Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom., PMID:34478462
Immunorecognition capacity of Indian polyvalent antivenom against venom toxins from two populations of Echis carinatus., PMID:34474069
The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming., PMID:34209691
Basement membrane degradation and inflammation play a role in the pulmonary hemorrhage induced by a P-III snake venom metalloproteinase., PMID:33872676
Examination of the Efficacy and Cross-Reactivity of a Novel Polyclonal Antibody Targeting the Disintegrin Domain in SVMPs to Neutralize Snake Venom., PMID:33807363
Snake venom proteome of Protobothrops mucrosquamatus in Taiwan: Delaying venom-induced lethality in a rodent model by inhibition of phospholipase A2 activity with varespladib., PMID:33359941
Gamma irradiated protease from Echis pyramidum venom: A promising immunogen to improve viper bites treatment., PMID:33065201
Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy., PMID:32841740
Venom variation in Bothrops asper lineages from North-Western South America., PMID:32829066
The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox)., PMID:32511239
Proteomic Analysis of Sri Lanka Echis carinatus Venom: Immunological Cross-Reactivity and Enzyme Neutralization Potency of Indian Polyantivenom., PMID:32501701
Proteomic and toxinological characterization of Peruvian pitviper Bothrops brazili ("jergón shushupe"), venom., PMID:32479836
Generation and In-planta expression of a recombinant single chain antibody with broad neutralization activity on Bothrops pauloensis snake venom., PMID:32035152
Amplification of Snake Venom Toxicity by Endogenous Signaling Pathways., PMID:31979014
Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins., PMID:31017792
Functional variability of Bothrops atrox venoms from three distinct areas across the Brazilian Amazon and consequences for human envenomings., PMID:30991062
Venom Composition in a Phenotypically Variable Pit Viper ( Trimeresurus insularis) across the Lesser Sunda Archipelago., PMID:30958009
Intact protein mass spectrometry reveals intraspecies variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey., PMID:30763806
Venomics of Trimeresurus (Popeia) nebularis, the Cameron Highlands Pit Viper from Malaysia: Insights into Venom Proteome, Toxicity and Neutralization of Antivenom., PMID:30736335
Vipera berus berus Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom., PMID:30717298
Human Monoclonal scFvs that Neutralize Fribrinogenolytic Activity of Kaouthiagin, a Zinc-Metalloproteinase in Cobra (Naja kaouthia) Venom., PMID:30513883
Identification of a linear B-cell epitope in the catalytic domain of bothropasin, a metalloproteinase from Bothrops jararaca snake venom., PMID:30399490
Venom proteome of Bungarus sindanus (Sind krait) from Pakistan and in vivo cross-neutralization of toxicity using an Indian polyvalent antivenom., PMID:30385415
Proteomic profile, biological activities and antigenic analysis of the venom from Bothriopsis bilineata smaragdina ("loro machaco"), a pitviper snake from Peru., PMID:30048773
Proteomics, functional characterization and antivenom neutralization of the venom of Pakistani Russell's viper (Daboia russelii) from the wild., PMID:29729992
Transcriptomics-guided bottom-up and top-down venomics of neonate and adult specimens of the arboreal rear-fanged Brown Treesnake, Boiga irregularis, from Guam., PMID:29292096
Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo., PMID:28425175
Combined venomics, antivenomics and venom gland transcriptome analysis of the monocoled cobra (Naja kaouthia) from China., PMID:28263888
Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus)., PMID:28238904
Snake Venom Metalloproteinases and Their Peptide Inhibitors from Myanmar Russell's Viper Venom., PMID:28042812