Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Research Biosimilar

Research Grade Mavrilimumab

Catalog #:   DHD11501 Specific References (91) DATASHEET
Host species: Human
Isotype: IgG4-lambda2
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHD11501

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG4-lambda2

Clonality

Monoclonal

Target

CD116, CSF2R, GMR-alpha, CSF2RA, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, CSF2RY, GMCSFR-alpha, GM-CSF-R-alpha, CDw116

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15509

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CAM-3001, CAS: 1085337-57-0

Clone ID

Mavrilimumab

Data Image
  • SDS-PAGE
    SDS PAGE for Mavrilimumab
  • Bioactivity
    Detects CD116/CSF2RA in indirect ELISAs.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study, PMID: 32835256

Mavrilimumab: a unique insight and update on the current status in the treatment of rheumatoid arthritis, PMID: 31208237

Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis, PMID: 24648832

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies, PMID: 32719685

Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody: Long-Term Safety and Efficacy in Patients With Rheumatoid Arthritis, PMID: 29361199

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date, PMID: 28144129

Investigational therapies targeting the granulocyte macrophage colony-stimulating factor receptor-α in rheumatoid arthritis: focus on mavrilimumab, PMID: 29387176

Rheumatoid arthritis: Long-term mavrilimumab safe and effective, PMID: 29416133

Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy, PMID: 23094973

Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review, PMID: 33068263

Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis, PMID: 32033937

A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis, PMID: 28941039

Rheumatoid arthritis: new monoclonal antibodies, PMID: 29771256

Mavrilimumab for severe COVID-19, PMID: 33521662

Mavrilimumab for severe COVID-19, PMID: 33521661

Mavrilimumab for severe COVID-19 - Authors' reply, PMID: 33521663

Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis, PMID: 30358109

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study, PMID: 21613310

Targeting Granulocyte-Monocyte Colony-Stimulating Factor Signaling in Rheumatoid Arthritis: Future Prospects, PMID: 31486005

Safety and Efficacy of Mavrilimumab For Rheumatoid Arthritis: A Systematic Review and Meta-Analysis, PMID: 33185165

Model-Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab, PMID: 28836356

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis, PMID: 23234647

A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis, PMID: 28213566

Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review, PMID: 34409778

Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety, PMID: 24937321

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial, PMID: 33754144

Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: findings from a Phase IIa study, PMID: 24720551

Comparison of the efficacy and safety of tofacitinib and mavrilimumab in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials, PMID: 33860755

Mechanistic modeling of antigen sink effect for mavrilimumab following intravenous administration in patients with rheumatoid arthritis, PMID: 21947370

Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis, PMID: 29069507

The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFRα-mAb treatment in rheumatoid arthritis patients, PMID: 30418117

Targeting GM-CSF in rheumatoid arthritis, PMID: 27586802

GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential, PMID: 25748625

GM-CSF as a therapeutic target in inflammatory diseases, PMID: 23933508

Innate and Adaptive Immunity in Giant Cell Arteritis, PMID: 33717054

Pulmonary pharmacodynamics of an anti-GM-CSFRα antibody enables therapeutic dosing that limits exposure in the lung, PMID: 27560702

Novel targeted therapies: the future of rheumatoid arthritis? Mavrilumab and tabalumab as examples, PMID: 23625979

Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma, PMID: 30649752

Market watch: Upcoming market catalysts in Q4 2015, PMID: 26338153

Quantitative measurement of the target-mediated internalization kinetics of biopharmaceuticals, PMID: 25208874

Giant cell arteritis: what is new in the preclinical and early clinical development pipeline?, PMID: 34106030

Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy., PMID:39755463

Network-Based In Silico Analysis of New Combinations of Modern Drug Targets with Methotrexate for Response-Based Treatment of Rheumatoid Arthritis., PMID:38003865

Giant Cell Arteritis and Polymyalgia Rheumatica: Treatment Approaches and New Targets., PMID:37331730

Recent advances in the diagnosis and therapy of large vessel vasculitis., PMID:35699647

Treatment of Giant Cell Arteritis (GCA)., PMID:35407411

Advances in the Treatment of Giant Cell Arteritis., PMID:35329914

Efficacy and safety of mavrilimumab in giant cell arteritis: a phase 2, randomised, double-blind, placebo-controlled trial., PMID:35264321

Specific Interleukin-1 Inhibitors, Specific Interleukin-6 Inhibitors, and GM-CSF Blockades for COVID-19 (at the Edge of Sepsis): A Systematic Review., PMID:35126138

Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells, pro-inflammatory markers and neoangiogenesis in ex vivo cultured arteries from patients with giant cell arteritis., PMID:35045965

The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies., PMID:34867318

Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover., PMID:34778899

Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review., PMID:34409778

Giant cell arteritis: what is new in the preclinical and early clinical development pipeline?, PMID:34106030

Comparison of the efficacy and safety of tofacitinib and mavrilimumab in patients with active rheumatoid arthritis: A Bayesian network meta-analysis of randomized controlled trials., PMID:33860755

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial., PMID:33754144

Innate and Adaptive Immunity in Giant Cell Arteritis., PMID:33717054

Mavrilimumab for severe COVID-19 - Authors' reply., PMID:33521663

Mavrilimumab for severe COVID-19., PMID:33521662

Mavrilimumab for severe COVID-19., PMID:33521661

Safety and Efficacy of Mavrilimumab For Rheumatoid Arthritis: A Systematic Review and Meta-Analysis., PMID:33185165

Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review., PMID:33068263

GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study., PMID:32835256

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies., PMID:32719685

Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis., PMID:32033937

Targeting Granulocyte-Monocyte Colony-Stimulating Factor Signaling in Rheumatoid Arthritis: Future Prospects., PMID:31486005

Mavrilimumab: a unique insight and update on the current status in the treatment of rheumatoid arthritis., PMID:31208237

Evaluation of Antibody Properties and Clinically Relevant Immunogenicity, Anaphylaxis, and Hypersensitivity Reactions in Two Phase III Trials of Tralokinumab in Severe, Uncontrolled Asthma., PMID:30649752

The VICM biomarker is released from activated macrophages and inhibited by anti-GM-CSFRα-mAb treatment in rheumatoid arthritis patients., PMID:30418117

Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis., PMID:30358109

Rheumatoid arthritis: new monoclonal antibodies., PMID:29771256

Rheumatoid arthritis: Long-term mavrilimumab safe and effective., PMID:29416133

Investigational therapies targeting the granulocyte macrophage colony-stimulating factor receptor-α in rheumatoid arthritis: focus on mavrilimumab., PMID:29387176

Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody: Long-Term Safety and Efficacy in Patients With Rheumatoid Arthritis., PMID:29361199

Blockade of GM-CSF pathway induced sustained suppression of myeloid and T cell activities in rheumatoid arthritis., PMID:29069507

A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis., PMID:28941039

Model-Based Discovery and Development of Biopharmaceuticals: A Case Study of Mavrilimumab., PMID:28836356

A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis., PMID:28213566

Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date., PMID:28144129

Targeting GM-CSF in rheumatoid arthritis., PMID:27586802

Pulmonary pharmacodynamics of an anti-GM-CSFRα antibody enables therapeutic dosing that limits exposure in the lung., PMID:27560702

Market watch: Upcoming market catalysts in Q4 2015., PMID:26338153

GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential., PMID:25748625

Quantitative measurement of the target-mediated internalization kinetics of biopharmaceuticals., PMID:25208874

Nonclinical safety of mavrilimumab, an anti-GMCSF receptor alpha monoclonal antibody, in cynomolgus monkeys: relevance for human safety., PMID:24937321

Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: findings from a Phase IIa study., PMID:24720551

Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis., PMID:24648832

GM-CSF as a therapeutic target in inflammatory diseases., PMID:23933508

Novel targeted therapies: the future of rheumatoid arthritis? Mavrilumab and tabalumab as examples., PMID:23625979

Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis., PMID:23234647

Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy., PMID:23094973

Datasheet

Document Download

Research Grade Mavrilimumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Research Grade Mavrilimumab [DHD11501]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only