Anti-TBK1 Polyclonal Antibody

Catalog No.

PHJ75801

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human TBK1 (Met1-Gly121).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Serine/threonine-protein kinase TBK1,NAK,TANK-binding kinase 1,T2K,TBK1,NF-kappa-B-activating kinase

Purification

Purified by antigen affinity column.

Accession

Q9UHD2

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Macrophage activation determines muscle wasting in pancreatic cancer., PMID:40442475

[Buzhong Yiqi Decoction alleviates immune injury of autoimmune thyroiditis in NOD.H-2~(h4)mice via c GAS-STING signaling pathway]., PMID:40350879

Treatment with human placental extracts inhibits allergic rhinitis by modulating AMPK/SHP1/SHP2/STING signaling., PMID:40280106

Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy., PMID:40098909

Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1., PMID:40083918

ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI., PMID:39903532

Interleukin-32 positive immune and resident cells in kidney samples from lupus patients: a pilot study., PMID:39835128

Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma., PMID:39658648

Development and characterization of high-efficiency cell-adapted live attenuated vaccine candidate against African swine fever., PMID:39584308

TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases., PMID:39562788

Avian TRIM13 attenuates antiviral innate immunity by targeting MAVS for autophagic degradation., PMID:39508267

Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer., PMID:39297058

Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer., PMID:39059614

PLK1-activating IFI16-STING-TBK1 pathway induces apoptosis of intestinal epithelial cells in patients with intestinal Behçet's syndrome., PMID:38676954

Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response., PMID:38597182

Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation., PMID:38233853

Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice., PMID:38190983

STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-κB signal pathway., PMID:38186000

Ginsenoside Rh2 augmented anti-PD-L1 immunotherapy by reinvigorating CD8+ T cells via increasing intratumoral CXCL10., PMID:37984507

Recombinant immunotoxin induces tumor intrinsic STING signaling against head and neck squamous cell carcinoma., PMID:37898690

Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review., PMID:37559153

Establishment and characterization of Yellow River carp (Cyprinus carpio haematopterus) muscle cell line and its application to fish virology and immunology., PMID:37277052

IgA2 immune complexes selectively promote inflammation by human CD103+ dendritic cells., PMID:37006318

Chicken infectious anemia virus (CIAV) VP1 antagonizes type I interferon (IFN-I) production by inhibiting TBK1 phosphorylation., PMID:36809820

Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence., PMID:36415206

TBK1 Isoform Inhibits Grass Carp Reovirus Infection by Targeting the Degradation of Viral Nonstructural Proteins NS80 and NS38., PMID:36445692

CS12192, a Novel JAK3/JAK1/TBK1 Inhibitor, Synergistically Enhances the Anti-Inflammation Effect of Methotrexate in a Rat Model of Rheumatoid Arthritis., PMID:36362183

Global Phosphoproteomics Unveils Kinase-Regulated Networks in Systemic Lupus Erythematosus., PMID:36309313

Glycolaldehyde-derived advanced glycation end products suppress STING/TBK1/IRF3 signaling via CD36., PMID:36302498

Rubella Virus Triggers Type I Interferon Antiviral Response in Cultured Human Neural Cells: Involvement in the Control of Viral Gene Expression and Infectious Progeny Production., PMID:36077193

Contribution of IL-38 in Lung Immunity during Pseudomonas Aeruginosa-induced Pneumonia., PMID:35583912

Effects of substituting soybean meal with corn on immune function and gene expression of gut TLR4 pathway of growing goats., PMID:35186490

STING agonist enhances the efficacy of programmed death-ligand 1 monoclonal antibody in breast cancer immunotherapy by activating the interferon-β signalling pathway., PMID:35130108

The potential value of amlexanox in the treatment of cancer: Molecular targets and therapeutic perspectives., PMID:34968491

B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice., PMID:34910106

Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23., PMID:34903664

TBK1 recruitment to STING mediates autoinflammatory arthritis caused by defective DNA clearance., PMID:34901991

FAF1 downregulation by Toxoplasma gondii enables host IRF3 mobilization and promotes parasite growth., PMID:34464509

The adjuvanticity of manganese for microbial vaccines via activating the IRF5 signaling pathway., PMID:34363796

BCMA-Specific ADC MEDI2228 and Daratumumab Induce Synergistic Myeloma Cytotoxicity via IFN-Driven Immune Responses and Enhanced CD38 Expression., PMID:34301753

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING., PMID:34289354

Type I interferon is induced by hemolysis and drives antibody-mediated erythrophagocytosis in sickle cell disease., PMID:34166491

Reovirus enhances cytotoxicity of natural killer cells against colorectal cancer via TLR3 pathway., PMID:33933132

PARP inhibitor niraparib as a radiosensitizer promotes antitumor immunity of radiotherapy in EGFR-mutated non-small cell lung cancer., PMID:33774805

Manganese Breaks the Immune Tolerance of HBs-Ag., PMID:33614817

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms., PMID:33459343

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway., PMID:33354501

EGFR inhibition triggers an adaptive response by co-opting antiviral signaling pathways in lung cancer., PMID:33269343

Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses., PMID:33154747

Plasmodium yoelii Uses a TLR3-Dependent Pathway to Achieve Mammalian Host Parasitism., PMID:33148715

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