Catalog No.
YME37701
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Met1-Ser135
Predicted molecular weight
16.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51480
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cyclin-dependent kinase inhibitor 2A, Cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4a, p16-INK4, Cdkn2a, P16ink4a
Spatial Distribution and Prognostic Value of T Cell Subtypes and Immune Biomarkers in p16-Negative HNSCC., PMID:40497965
[Combined detection of p16 and Rb with high-risk human papilloma virus infection in non-oropharyngeal squamous cell carcinoma of the head and neck]., PMID:40494765
Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation., PMID:40493738
Assessment of CDKN2A homozygous and heterozygous deletions in gliomas across multiple detection platforms., PMID:40474207
Fibroblasts-specific p16INK4a exacerbates inflammageing-mediated post-infarction ventricular remodelling through interacting with STAT3 to regulate NLRP3 transcription., PMID:40462499
[Mechanism of matrine against senescence in human umbilical vein endothelial cells based on network pharmacology and experimental verification]., PMID:40461235
Cuproptosis-related gene signatures define the immune microenvironment in diabetic nephropathy., PMID:40460381
Evidence of mutations in tumour suppressor genes among oral cancer in Naswar, smokeless tobacco users., PMID:40457841
A comparison of CDKN2A status in gliomas using different techniques: The loss of p16 as a surrogate marker., PMID:40445894
Detection of hotspot mutations in oral cancer through Ion AmpliSeq™ cancer hotspot panel v.2.0: A circulating DNA fragmentomics approach in the Northeast Indian population., PMID:40440828
Role of the SPI1/CDKN2A/p53 signaling pathway in cuproptosis of lung adenocarcinoma cells., PMID:40438868
Polygenic Risk Score Analysis of 37 SNPs Associated with Melanoma Risk in Colombian Population., PMID:40429816
Pancreatic adenocarcinoma in a patient with a germline RB1 pathogenic variant., PMID:40418431
Myocardial infarction activates the 9p21.3 orthologous locus expression, but its absence does not alter cardiac pathophysiology in ischemia., PMID:40405527
Repurposing HIV protease inhibitors as senotherapeutic agents in cervical cancer: Dual targeting of CDK1/6-cell cycle arrest and p53/p21/p16 signaling axis., PMID:40403681
Palbociclib, a Selective CDK4/6 Inhibitor, Administered Before and After Chemoradiotherapy for Human Papillomavirus-Negative, Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm, Phase II Trial., PMID:40403207
Development of a highly sensitive, label-free electrochemical immunosensor for p16INK4a detection: a step toward early cervical cancer diagnosis., PMID:40396400
Improving Detection of CIN2+ and CIN3+ Lesions: Evaluation of E6/E7 mRNA, P16, and Ki-67, Individually and in Combination., PMID:40392038
Atf3 + senescent chondrocytes mediate meniscus degeneration in aging., PMID:40375324
Role of genomic analysis in the classification of well differentiated hepatocellular lesions., PMID:40374146
Diagnostic Accuracy of Serum P16ink4A and FOX-P3 Concentrations for Detection of Cervical Lesions Among Women Attending a Cervical Cancer Clinic in Western Uganda: A Case-Control Study., PMID:40365511
Radiation-Induced Synchronous Parathyroid Carcinoma and Papillary Thyroid Carcinoma: Clinical, Morphological, and Genetic Insights., PMID:40362680
Molecular Mechanisms of Tumor Progression and Novel Therapeutic and Diagnostic Strategies in Mesothelioma., PMID:40362535
Radiation-Induced Meningiomas Have an Aggressive Clinical Course: Genetic Signature Is Limited to NF2 Alterations, and Epigenetic Signature Is H3K27me3 Loss., PMID:40359980
P16 hypermethylation is a potential cause of oxidative stress due to long-term exposure to hexavalent chromium., PMID:40358560
A Dominant Mutation in Gαs-Protein Increases Hair Pigmentation., PMID:40356280
Elevated Type I Interferon Signaling Defines the Proliferative Advantage of ARF and p53 Mutant Tumor Cells., PMID:40351125
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma., PMID:40350470
Plasmacytoid urothelial carcinoma of the urinary bladder: A single institution experience with focus on next-generation sequencing (NGS) and PD-L1 immunohistochemistry., PMID:40349989
Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease., PMID:40348745
Identification of programmed cell death-related genes and construction of a prognostic model in oral squamous cell carcinoma using single-cell and transcriptome analysis., PMID:40346375
Clinical characteristics and treatment outcome in p16 negative anal cancer., PMID:40336180
Downregulation of EZH2 Promotes Renal Epithelial Cellular Senescence and Kidney Aging., PMID:40326780
[Prognostic Value of CDKN2A Copy Number Deletion in Patients with Diffuse Large B-Cell Lymphoma]., PMID:40326108
Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti-PD1 resistance in skin cutaneous melanoma., PMID:40324810
Establishment and validation of a novel risk model based on PANoptosis-related genes to predict prognosis in head and neck squamous cell carcinoma., PMID:40324259
Preoperative prediction of p16 expression in cervical cancer by amide proton transfer imaging combined with diffusion kurtosis imaging: a retrospective study., PMID:40321828
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways., PMID:40319296
Combination therapy of adagrasib and abemaciclib in non-small cell lung cancer brain metastasis models genomically characterized by KRAS-G12C and homozygous loss of CDKN2A., PMID:40317086
A model workflow for microfluidic enrichment and genetic analysis of circulating melanoma cells., PMID:40316673
Diagnostic Utility of Preferentially Expressed Antigen in Melanoma (PRAME) and p16 Immunohistochemistry in Distinguishing Genital Melanomas From Benign Melanocytic Proliferations., PMID:40314660
A novel immortalization method for immortalizing human primary CD8+ T cells by inserting a single copy of human telomerase reverse transcriptase via CRISPR/Cas9., PMID:40311322
Genetic alterations of Cyclin D-CDK4/6-INK4-RB pathway in prostate cancer., PMID:40304827
Lower levels of senescence in human lung mesenchymal stromal cells compared with lung fibroblasts: implications for tissue regeneration in COPD., PMID:40304287
Molecular characteristics and responses to EGFR tyrosine kinase inhibitors in non-small cell lung cancer patients with EGFR exon 19 insertions., PMID:40301895
TGFBR2 as a prognostic marker and therapeutic target in benzo(a)pyrene-associated esophageal cancer: insights from multi-omics analysis., PMID:40293202
Treatment outcomes of BTK inhibitors and venetoclax with or without anti-CD20 monoclonal antibody in relapsed or refractory mantle cell lymphoma., PMID:40278919
Accelerated senescence of bone marrow erythrocyte precursors in myelodysplastic syndrome., PMID:40277030
Loss of ALDH2 accelerates the progression of pulmonary arterial hypertension through the 4-HNE/ERK1/2-p16INK4a signaling pathway., PMID:40274079
Human papillomavirus (HPV) related oropharyngeal cancers in Canada: A multicenter retrospective cohort study., PMID:40264440
For research use only. Not for human or drug use.
