Catalog No.
PHJ73201
Species reactivity
Human, Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human DKK3 (Ala37-Ile350).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Dkk-3,Dickkopf-related protein 3,Dickkopf-3,hDkk-3,DKK3,REIC
Concentration
1.425 mg/ml
Purification
Purified by antigen affinity column.
Accession
Q9UBP4
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
ZBED6 Knockout Prevents Ageing- and Dexamethasone-Induced Muscle Atrophy via Dkk3 in Pig and Mice., PMID:40464206
Immunoliposome-based targeted delivery of the CRISPR/Cas9gRNA-IL30 complex inhibits prostate cancer and prolongs survival., PMID:39232121
Biomarkers of fibrosis, kidney tissue injury and inflammation may predict severity and outcome of renal ANCA - associated vasculitis., PMID:37020541
A proof of concept for targeting the PrPC - Amyloid β peptide interaction in basal prostate cancer and mesenchymal colon cancer., PMID:35962130
DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer., PMID:35708905
Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice., PMID:35659360
REIC/Dkk-3 Gene Therapy Induces Immunogenic Cell Death in a Mouse Model of Malignant Mesothelioma., PMID:34593432
Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration., PMID:34214452
Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer Patients., PMID:33488097
The Suppressing Effects of Dkk3 Expression on Aggressiveness and Tumorigenesis of Colorectal Cancer., PMID:33425757
Human amniotic mesenchymal stem cells inhibit hepatocellular carcinoma in tumour-bearing mice., PMID:32798252
Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy., PMID:32345717
Cervicovaginal Fluid Protein Microarray for Detection of Microbial Invasion of the Amniotic Cavity in Preterm Labor., PMID:32046420
Extensive serum biomarker analysis in patients with non-small-cell lung carcinoma., PMID:31629110
Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options., PMID:30770859
Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma., PMID:30355799
p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4., PMID:30181180
Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration., PMID:29980568
Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO)., PMID:29932883
Tumor necrosis factor-α downregulates the REIC/Dkk-3 tumor suppressor gene in normal human skin keratinocytes., PMID:29512745
The hormetic functions of Wnt pathways in tubular injury., PMID:28685176
Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse., PMID:27866302
Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis., PMID:27699213
Increased Levels of Dickkopf 3 in the Aqueous Humor of Patients With Diabetic Macular Edema., PMID:27127928
Dickkopf-related Protein 3 as a Sensitive and Specific Marker for Cerebrospinal Fluid Leaks., PMID:26837002
Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction., PMID:25840773
Dickkopf-3, a tissue-derived modulator of local T-cell responses., PMID:25759692
Dickkopf-3 acts as a modulator of B cell fate and function., PMID:25672757
Dickkopf-3 (Dkk3) induces apoptosis in cisplatin-resistant lung adenocarcinoma cells via the Wnt/β-catenin pathway., PMID:25573172
Wnt modulators in the aqueous humor are associated with outer retinal damage severity in patients with neovascular age-related macular degeneration., PMID:25034605
Dkk2/Frzb in the dermal papillae regulates feather regeneration., PMID:24463139
A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells., PMID:24286133
Limbal dermoid epithelium shares phenotypic characteristics common to both hair epidermal and limbal epithelial stem cells., PMID:23573994
The roles of REIC gene and its encoding product in gastric carcinoma., PMID:22421143
Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance., PMID:22307622
Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cells., PMID:21743013
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation., PMID:20795789
Molecular architecture of the DNA replication origin activation checkpoint., PMID:20729811
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis., PMID:19633687
Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of interleukin-7., PMID:19279003
Increase of Dkk-3 blood plasma levels in the elderly., PMID:18573329
REIC/Dkk-3 induces cell death in human malignant glioma., PMID:18443132
The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formation., PMID:18033687
Dickkopf-3 is expressed in a subset of adult human pancreatic beta cells., PMID:17347849
Generation and characterization of dickkopf3 mutant mice., PMID:16508007
Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma., PMID:14767340
For research use only. Not for human or drug use.
